Griesbach, Colin

[["dc.bibliographiccitation.firstpage","317"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Vasa"],["dc.bibliographiccitation.lastpage","322"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Meyer, Alexander"],["dc.contributor.author","Griesbach, Colin"],["dc.contributor.author","Maudanz, Nils"],["dc.contributor.author","Lang, Werner"],["dc.contributor.author","Almasi-Sperling, Veronika"],["dc.contributor.author","Rother, Ulrich"],["dc.date.accessioned","2022-04-20T13:58:10Z"],["dc.date.available","2022-04-20T13:58:10Z"],["dc.date.issued","2020"],["dc.description.abstract","Background: To analyze long-term outcomes and possible influencing factors in patients with endstage renal disease (ESRD) and critical limb ischemia (CLI) after major amputation compared to patients with normal renal function and non-dialysis-dependent chronic kidney disease. Patients and methods: Abstraction of single-center medical records of patients undergoing above knee (AKA) and below knee (BKA) amputation over a 10 years period (n = 436; 2009–2018). Excluded were amputations due to trauma or tumor. Patients were subdivided according to renal function in three categories: ESRD patients (n = 98), non-dialysis dependent chronic kidney disease (CKD, n = 98) and normal renal function (NF, n = 240). Predefined endpoints were survival and postoperative complications. Cox-regression models were built to analyze independent risk factors for outcome parameters. Results: In total, 298 AKA, 133 BKA and 5 knee joint exarticulations were performed. ESRD patients showed inferior in-hospital results as to death (ESRD 36.7 % vs. CKD 19.4 % and NF 20.0 %, P = .002). Similarly, long-term survival rates (6 months: ESRD 55.0 % vs. CKD 69.4 %, NF 67.9 % 1 year: ESRD 48.6 %, CKD 60.2 %, NF 60.8 % 5 years: ESRD 9.9 %, CKD 31.8 %, NF 37.1 %, P < .001) were significantly decreased for ESRD patients. Median postoperative survival was 10 months in ERSD, and 22 months in CKD and NF, respectively. Analysis of postoperative surgical complications revealed no differences between groups (ESRD 19.4 %, CKD 17.3 %, NF 17.0 %; P = 0.433). Cox regression analysis indicated that dialysis (HR 1.63; 95 % CI 1.22–2.16; P = .001), hypertension (HR 1.59; 95 % CI 0.99–2.54) and smoking (HR 1.22; 95 % CI 1.03–1.44; P = .022) was associated with increased risk of death during follow-up. Conclusions: Mortality after limb amputation in ERSD patients remains high. Survival of ERSD patients is lower in relation to chronic kidney disease and patients with normal renal function. Due to poor in hospital outcomes and absent long-term survival, benefit of primary amputation in ERSD seems scarce."],["dc.identifier.doi","10.1024/0301-1526/a000856"],["dc.identifier.pmid","32160821"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106584"],["dc.language.iso","en"],["dc.relation.issn","0301-1526"],["dc.relation.issn","1664-2872"],["dc.title","Influence of end-stage renal disease on long-term survival after major amputation"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e001316"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMJ Open Diabetes Research & Care"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Rother, Ulrich"],["dc.contributor.author","Grussler, Anna"],["dc.contributor.author","Griesbach, Colin"],["dc.contributor.author","Almasi-Sperling, Veronika"],["dc.contributor.author","Lang, Werner"],["dc.contributor.author","Meyer, Alexander"],["dc.date.accessioned","2022-04-20T13:57:59Z"],["dc.date.available","2022-04-20T13:57:59Z"],["dc.date.issued","2020"],["dc.description.abstract","Introduction Compression therapy is highly effective in the treatment of many venous diseases, including leg edema. However, its relevance in patients with peripheral arterial disease (PAD) or diabetes mellitus is critically discussed. The aim of the present study was to assess the influence of compression therapy on microperfusion and its safety in patients with PAD or diabetes mellitus. Research design and methods A prospective analysis of 94 consecutive patients (44 patients with diabetes, 45 patients with PAD and 5 healthy controls) undergoing medical compression therapy was performed. Microperfusion was assessed by a combined method of white light tissue spectrometry and laser Doppler flowmetry under medical compression therapy (classes I and II), in different body positions (supine, sitting, standing and elevated position of the leg) and at different locations (great toe, lateral ankle and calf). Results During the entire study, no compression-related adverse events occurred. Evaluation of microcirculation parameters (oxygen saturation of hemoglobin and flow) at the different locations and in sitting and standing positions (patients with diabetes and PAD) under compression therapy classes I and II revealed no tendency for reduced microperfusion in both groups. In contrast, in the elevated leg position, all mean perfusion values decreased in the PAD and diabetes groups. However, the same effect was seen in the healthy subgroup. Conclusions In consideration of the present inclusion criteria, use of medical compression stockings is safe and feasible in patients with diabetes or PAD. This study did not find relevant impairment of microperfusion parameters under compression therapy in these patient subgroups in physiologic body positions."],["dc.identifier.doi","10.1136/bmjdrc-2020-001316"],["dc.identifier.pmid","32503811"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106583"],["dc.language.iso","en"],["dc.relation.eissn","2052-4897"],["dc.title","Safety of medical compression stockings in patients with diabetes mellitus or peripheral arterial disease"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]