Recyclable Ruthenium Catalyst for Distal meta ‐C−H Activation

Abstract We disclose the unprecedented hybrid‐ruthenium catalysis for distal meta‐C−H activation. The hybrid‐ruthenium catalyst was recyclable, as was proven by various heterogeneity tests, and fully characterized with various microscopic and spectroscopic techniques, highlighting the physical and chemical stability. Thereby, the hybrid‐ruthenium catalysis proved broadly applicable for meta‐C−H alkylations of among others purine‐based nucleosides and natural product conjugates. Additionally, its versatility was further reflected by meta‐C−H activations through visible‐light irradiation, as well as para‐selective C−H activations.

Don't say goodbye! Recyclable ruthenium catalyst enabled diverse distal C−H functionalization. State‐of‐the‐art spectroscopic and spectrometric characterizations highlighted physical and chemical stability of reusable hybrid‐ruthenium catalyst. Robustness and versatility of hybrid‐ruthenium catalysis was further reflected by meta‐ and para‐selectivity as well as visible‐light‐induced reactivity. image