Towards click bioconjugations on cube-octameric silsesquioxane scaffolds

ISSN
1477-0520
Date Issued
2010
Author(s)
Fabritz, Sebastian
Heyl, Dirk
Bagutski, Viktor
Empting, Martin
Rikowski, Eckhard
Balog, Ildiko
Fessner, Wolf-Dieter
Schneider, Joerg. J.
Avrutina, Olga
Kolmar, Harald
DOI
10.1039/b923393h
Abstract
Cube-octameric silsesquioxane (POSS) based conjugation scaffolds for copper catalysed azide-alkyne [3+2] cycloaddition are reported. The synthetic route to octaazido and octaalkyno functionalised POSS templates without cage rearrangements is described. A set of click couplings is conducted including the first effective conjugation with a fully unprotected functional peptide towards a POSS assembled peptide octamer.