Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

ISSN
1080-6059
1080-6040
Date Issued
2014
Author(s)
Douet, Jean Yves
Perret-Liaudet, Armand
Lacroux, Caroline
Lugan, Severine
Aron, Naima
Cassard, Herve
Corbiere, Fabien
Torres, Juan Maria
Andreoletti, Olivier
DOI
10.3201/eid2001.130353
Abstract
We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to those reported in various animals with transmissible spongiform encephalopathies.