Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates

Date Issued
2017
Author(s)
Reiner, Anne M.
Schmidt, Felix
Weckbecker, Daniel
Deeg, Andreas A.
Giese, Armin
Zinth, Wolfgang
DOI
10.1016/j.bbagen.2017.12.007
Abstract
Recently diphenyl-pyrazole (DPP) compounds and especially anle138b were found to reduce the aggregation of α-synuclein or Tau protein in vitro as well as in a mouse model of neurodegenerative diseases . Direct interaction of the DPPs with the fibrillar structure was identified by fluorescence spectroscopy. Thereby a strong dependence of the fluorescence on the surroundings could be identified .