Versatile Synthesis of Isocoumarins and alpha-Pyrones by Ruthenium-Catalyzed Oxidative C-H/O-H Bond Cleavages

ISSN
1523-7060
Date Issued
2012
Author(s)
Pospech, Jola
Graczyk, Karolina
DOI
10.1021/ol2034614
Abstract
An inexpensive cationic ruthenium(II) catalyst enabled the expedient synthesis of isocoumarins through oxidative annulations of alkynes by benzoic acids. This C-H/O-H bond functionalization process also proved applicable to the preparation of alpha-pyrones and was shown to proceed by rate-limiting C-H bond ruthenation.