Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

ISSN
1055-9965
1538-7755
Date Issued
2019
Author(s)
Zhu, Ying
Wei, Yongyue
Zhang, Ruyang
Dong, Xuesi
Shen, Sipeng
Zhao, Yang
Bai, Jianling
Albanes, Demetrius
Caporaso, Neil E.
Landi, Maria Teresa
Zhu, Bin
Chanock, Stephen J.
Gu, Fangyi
Lam, Stephen
Tsao, Ming-Sound
Shepherd, Frances A.
Tardon, Adonina
Fernández-Somoano, Ana
Fernandez-Tardon, Guillermo
Chen, Chu
Barnett, Matthew J.
Doherty, Jennifer
Bojesen, Stig E.
Johansson, Mattias
Brennan, Paul
McKay, James D.
Carreras-Torres, Robert
Muley, Thomas
Risch, Angela
Wichmann, Heunz-Erich
Rennert, Gad
Saliba, Walid
Arnold, Susanne M.
Field, John K.
Davies, Michael P.A.
Marcus, Michael W.
Wu, Xifeng
Ye, Yuanqing
Le Marchand, Loic
Wilkens, Lynne R.
Melander, Olle
Manjer, Jonas
Brunnström, Hans
Hung, Rayjean J.
Liu, Geoffrey
Brhane, Yonathan
Kachuri, Linda
Andrew, Angeline S.
Duell, Eric J.
Kiemeney, Lambertus A.
van der Heijden, Erik HFM
Haugen, Aage
Zienolddiny, Shanbeh
Skaug, Vidar
Grankvist, Kjell
Johansson, Mikael
Woll, Penella J.
Cox, Angela
Taylor, Fiona
Teare, Dawn M.
Lazarus, Philip
Schabath, Matthew B.
Aldrich, Melinda C.
Houlston, Richard S.
McLaughlin, John
Stevens, Victoria L.
Shen, Hongbing
Hu, Zhibin
Dai, Juncheng
Amos, Christopher I.
Han, Younghun
Zhu, Dakai
Goodman, Gary E.
Chen, Feng
Christiani, David C.
DOI
10.1158/1055-9965.EPI-18-0356
Abstract
Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear.