Ruthenium-catalyzed oxidative alkyne annulation by C-H activation on ketimines

ISSN
0040-4020
Date Issued
2014
Author(s)
DOI
10.1016/j.tet.2013.10.003
Abstract
Carboxylate assistance allowed for ruthenium(II)-catalyzed oxidative alkyne annulations by ketimines under an ambient atmosphere of air. The ruthenium catalyst outperformed representative rhodium and palladium complexes, and provided versatile access to differently decorated 1-methylene-1,2-dihydroisoquinolines in a highly step- and atom-economical manner. Detailed mechanistic studies provided evidence for an initial reversible C-H bond activation event. (C) 2013 Elsevier Ltd. All rights reserved.