Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

ISSN
1521-3773
1433-7851
Date Issued
2014
Author(s)
Yang, F.
Kettelhoit, Katharina
DOI
10.1002/anie.201405647
Abstract
Versatile ruthenium(II) complexes allow for site-selective CH oxygenations with weakly-coordinating aldehydes. The challenging CH functionalizations proceed with high chemoselectivity by rate-determining CH metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.