Enantioselective Synthesis of [6]Carbohelicenes

ISSN
0002-7863
Date Issued
2017
Author(s)
Gonzalez-Fernandez, Elisa
Nicholls, Leo D. M.
Schaaf, Lukas D.
Farès, Christophe
Lehmann, Christian W.
DOI
10.1021/jacs.6b12443
Abstract
The use of alpha-cationic phosphonites derived from TADDOL as ancillary ligands has allowed a highly regio- and enantioselective synthesis of substituted [6]-carbohelicenes by sequential Au-catalyzed intramolecular hydroarylation of diynes. Key for these results is the modular structure of these new ligands, and the enhanced reactivity that they impart to Au(I)-centers after coordination.