SNARE derived peptide mimic inducing membrane fusion

ISSN
1364-548X
Date Issued
2011
Author(s)
Meyenberg, Karsten
Lygina, Antonina S.
van den Bogaart, Geert
DOI
10.1039/c1cc12879e
Abstract
SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.
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