Novel carboranyl C-glycosides for the treatment of cancer by boron neutron capture therapy

ISSN
0947-6539
Date Issued
2003
Author(s)
Griesbach, U.
Schuberth, I.
Marra, A.
Dondoni, A.
DOI
10.1002/chem.200390148
Abstract
The synthesis of the novel unprotected carboranyl C-glycosides 2 and 20 24 starting from ethynyl C-glycosides 1, 5-8, 10, and 13 is described. The new compounds are highly water-soluble and display only a very low cytotoxicity, which makes them promising candidates for use in boron neutron capture therapy for the treatment of cancer.