Lysosomal enzymes and their receptors

This review is limited to discussion of synthesis and transport of lysosomal enzymes in mammalian tissues. We focus on the processing of the oligosaccharides in lysosomal enzymes, on the mannose 6-phosphate-specific receptor (MPR), and on its role in the transport of lysosomal enzymes. The transport of lysosomal enzymes and the function of mannose 6-phosphate-specific receptors have been the subject of recent reviews (3-5).