Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy

ISSN
1524-4571
Date Issued
2015
Author(s)
Sprenger, Julia U.
Steinbrecher, Julia H.
Abesser, Marco
Schuh, Kai
DOI
10.1161/CIRCRESAHA.116.306082
Abstract
Cyclic nucleotides are second messengers that regulate cardiomyocyte function through compartmentalized signaling in discrete subcellular microdomains. However, the role of different microdomains and their changes in cardiac disease are not well understood.