O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is a rare event in soft tissue sarcoma

ISSN
1748-717X
Date Issued
2012-10-30
Author(s)
Hille, Maren
Sauer, Christian
Ströbel, Philipp
Wenz, Frederik
Hohenberger, Peter
DOI
10.1186/1748-717X-7-180
Abstract
Gene silencing of O6-methylguanine-DNA methyltransferase (MGMT) by promoter methylation improves the outcome of glioblastoma patients after combined therapy of alkylating chemotherapeutic agents and radiation. The purpose of this study was to assess the frequency of MGMT promoter methylation in soft tissue sarcoma to identify patients eligible for alkylating agent chemotherapy such as temozolomide.
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