BSE-associated Prion-Amyloid Cardiomyopathy in Primates

ISSN
1080-6059
1080-6040
Date Issued
2013
Author(s)
Krasemann, Susanne
Mearini, Giulia
Kraemer, Elisabeth
Wagenfuehr, Katja
Neumann, Melanie
Kaup, Franz-Josef
Beekes, Michael
Carrier, Lucie
Aguzzi, Adriano
Glatzel, Markus
DOI
10.3201/eid1906.120906
Abstract
Prion amyloidosis occurred in the heart of 1 of 3 macaques intraperitoneally inoculated with bovine spongiform encephalopathy prions. This macaque had a remarkably long duration of disease and signs of cardiac distress. Variant Creutzfeldt-Jakob disease, caused by transmission of bovine spongiform encephalopathy to humans, may manifest with cardiac symptoms from prion-amyloid cardiomyopathy.