Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells

ISSN
1748-717X
Date Issued
2011-10-06
Author(s)
Habermehl, Daniel
Mohr, Angela
Wuerth, Lena
Lindel, Katja
Weber, Klaus
Debus, Jürgen
Combs, Stephanie E
DOI
10.1186/1748-717X-6-132
Abstract
Sublethal photon irradiation was recently suspected to increase tumor cell motility and promote locoregional recurrence of disease. This study was set up to describe mechanisms underlying increased glioma cell migration through photon irradiation and to analyse the modifiability of photon-altered glioma cell motility by integrin inhibition.