Dextranomer microspheres (Deflux) in the endoscopic treatment of childhood vesicoureteric reflux

Purpose. Substances currently used for endoscopic correction of vesicoureteric reflux like Teflon, silicone or bovine collagen are critical with regard to biocompatibility. We investigated dextranomer microspheres (Deflux) in the endoscopic therapy of vesicoureteric reflux. Methods and Patients. Deflux was used in 29 children aged 20 months to 13,5 years (40 vesicoureteric units). Effectiveness of treatment was controlled by voiding cystourethrography 3 to 6 months afterwards. Results. Overall,the endoscopic treatment with Deflux was successful in 17 children and 23 vesicoureteric units. Infection associated reflux I degrees -III degrees was treated successfully in 17 of 19 children (=89,5%). In contrast, endoscopic therapy was not effective in children with reflux IV degrees and V degrees and in children with neurogenic bladder dysfunction. Conclusion. Deflux is an attractive alternative in the endoscopic treatment of vesicoureteric reflux in children. Especially, children with infection associated low-grad reflux may profit from this minimally invasive therapy.