A pre-structured helix in the intrinsically disordered 4EBP1

ISSN
1742-206X
Date Issued
2015
Author(s)
Kim, Do-Hyoung
Lee, Chewook
Cho, Ye-Jin
Lee, Si-Hyung
Cha, Eun-Ji
Lim, Ji-Eun
Han, Kyou-Hoon
DOI
10.1039/c4mb00532e
Abstract
The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.