Potential Involvement of Osteopontin in Inflammatory and Fibrotic Processes in Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension

ISSN
0340-6245
2567-689X
Date Issued
2019
Author(s)
Kölmel, Sebastian
Hobohm, Lukas
Käberich, Anja
Krieg, Valentin J.
Bochenek, Magdalena L.
Wenzel, Philip
Wiedenroth, Christoph B.
Liebetrau, Christoph
Mayer, Eckhard
Konstantinides, Stavros V.
Guth, Stefan
DOI
10.1055/s-0039-1692174
Abstract
 Inflammation and incomplete thrombus resolution leading to obstructive fibrotic remodelling are considered critical mechanisms for the development of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism (PE). Osteopontin (OPN) is involved in a variety of biological processes including inflammation and tissue fibrosis.