Cytokines of the IL‐17 family in psoriasis

ISSN
1610-0379
Date Issued
2020
Author(s)
Lauffer, Felix
Eyerich, Kilian
Boehncke, Wolf‐Henning
Asadullah, Khusru
Beissert, Stefan
Ghoreschi, Kamran
DOI
10.1111/ddg.14124
Abstract
Summary Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL‐17 family are of particular importance. In addition to IL‐17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL‐17 family also have a proinflammatory effect. This review provides an up‐to‐date overview of the immunopathogenesis of psoriasis with regard to the six IL‐17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.
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