Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes

ISSN
1524-4571
Date Issued
2014
Author(s)
Götz, Konrad R.
Sprenger, Julia U.
Steinbrecher, Julia H.
Kuhn, Michaela
Gorelik, Julia
Balligand, Jean-Luc
DOI
10.1161/CIRCRESAHA.114.302437
Abstract
3',5'-Cyclic guanosine monophosphate (cGMP) is an important second messenger that regulates cardiac contractility and protects the heart from hypertrophy. However, because of the lack of real-time imaging techniques, specific subcellular mechanisms and spatiotemporal dynamics of cGMP in adult cardiomyocytes are not well understood.