Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 I. Taxonomy, fermentation, isolation and biological activities

ISSN
0021-8820
Date Issued
2000
Author(s)
Schimana, J.
Fiedler, H. P.
Groth, I.
Sussmuth, R.
Beil, W.
Walker, M.
Abstract
Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tu 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.