Screening for biologically active metabolites with endosymbiotic bacilli isolated from arthropods

ISSN
0378-1097
Date Issued
2002
Author(s)
Gebhardt, Klaus
Schimana, J.
Müller, J.
Fiedler, Hans-Peter
Kallenborn, H. G.
Holzenkämpfer, M.
Krastel, P.
Vater, Joachim
Hotzel, A.
Schmid, D. G.
Rheinheimer, J.
Dettner, K.
DOI
10.1016/S0378-1097(02)01065-0
Abstract
Endosymbiotic bacteria from the genus Bacillus were isolated from different compartments of the gut of various members of insects (Hexapoda) and millipedes (Dipiopoda). They were grown in submerged culture and investigated by biological assays and HPLC-diode array analysis regarding their production of bioactive metabolites, which were isolated and determined in structure. Known compounds and yet unknown derivatives from the primary metabolism were detected, as well as antibacterially and antifungally acting peptide antibiotics. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.