Frequency-modulated SSFP with radial sampling and subspace reconstruction: A time-efficient alternative to phase-cycled bSSFP

Purpose A novel subspace‐based reconstruction method for frequency‐modulated balanced steady‐state free precession (fmSSFP) MRI is presented. In this work, suitable data acquisition schemes, subspace sizes, and efficiencies for banding removal are investigated. Theory and Methods By combining a fmSSFP MRI sequence with a 3D stack‐of‐stars trajectory, scan efficiency is maximized as spectral information is obtained without intermediate preparation phases. A memory‐efficient reconstruction routine is implemented by introducing the low‐frequency Fourier transform as a subspace which allows for the formulation of a convex reconstruction problem. The removal of banding artifacts is investigated by comparing the proposed acquisition and reconstruction technique to phase‐cycled bSSFP MRI. Aliasing properties of different undersampling schemes are analyzed and water/fat separation is demonstrated by reweighting the reconstructed subspace coefficients to generate virtual spectral responses in a post‐processing step. Results A simple root‐of‐sum‐of‐squares combination of the reconstructed subspace coefficients yields high‐SNR images with the characteristic bSSFP contrast but without banding artifacts. Compared to Golden‐Angle trajectories, turn‐based sampling schemes were superior in minimizing aliasing across reconstructed subspace coefficients. Water/fat separated images of the human knee were obtained by reweighting subspace coefficients. Conclusions The novel subspace‐based fmSSFP MRI technique emerges as a time‐efficient alternative to phase‐cycled bSFFP. The method does not need intermediate preparation phases, offers high SNR and avoids banding artifacts. Reweighting of the reconstructed subspace coefficients allows for generating virtual spectral responses with applications to water/fat separation.