Endophenazines A similar to D, new phenazine antibiotics from the arthropod associated endosymbiont Streptomyces anulatus I. Taxonomy, fermentation, isolation and biological activities

Four new members of the phenazine family, endophenazines Asimilar toD, and the already known phenazine-1-carboxylic acid (tubermycin B) were detected in the culture broth of various endosymbiotic Streptomyces anulatus strains by chemical screening in a combination of TLC-staining reagents and HPLC-diode array analysis. The endosymbiotic strains were isolated from four different arthropod hosts at various sites. The new phenazine compounds showed antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).