Elevated levels of serum SlOO beta protein in scrapie hamsters

ISSN
1355-0284
Date Issued
2009
Author(s)
Beekes, Michael
Diringer, Heino
DOI
10.3109/13550289809113503
Abstract
Recently, immunoluminometric analysis revealed elevated levels of serum SlOO beta protein in sporadic and genetic cases of Creutzfeldt-Jakob disease (CJD) as compared to demented and non-demented control patients (Otto et al, 1998). SlOO beta protein is a well established marker for the activation of astrocytes and also shows enhanced histochemical presentation in Alzheimer's disease (Sheng et al, 1997). Thus, it will be necessary to precisely assess the specificity of the new test for human transmissible spongiform encephalopathies (TSE) in larger study populations.