Giese, Alf

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Lankenau, Eva"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Huettmann, Gereon"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T11:21:41Z"],["dc.date.available","2018-11-07T11:21:41Z"],["dc.date.issued","2009"],["dc.format.extent","881"],["dc.identifier.isi","000272974100053"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55832"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology"],["dc.relation.eventlocation","Yokohama, JAPAN"],["dc.relation.issn","1522-8517"],["dc.title","OPTICAL COHERENCE TOMOGRAPHY FOR INTRAOPERATIVE ANALYSIS OF GLIOMA TISSUE MICROSTRUCTURE AND LIGHT ATTENUATION AS A NOVEL TECHNIQUE TO CONTROL THE EXTENT OF RESECTION"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","333"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","343"],["dc.bibliographiccitation.volume","152"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Fadini, Tommaso"],["dc.contributor.author","Finke, Markus"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Siemerkus, Jakob"],["dc.contributor.author","Bockermann, Volker"],["dc.contributor.author","Matthaeus, Lars"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Schweikard, Achim"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:45:57Z"],["dc.date.available","2018-11-07T08:45:57Z"],["dc.date.issued","2010"],["dc.description.abstract","Shape and exact location of motor cortical areas varies among individuals. The exact knowledge of these locations is crucial for planning of neurosurgical procedures. In this study, we have used robot-assisted image-guided transcranial magnetic stimulation (Ri-TMS) to elicit MEP response recorded for individual muscles and reconstruct functional motor maps of the primary motor cortex. One healthy volunteer and five patients with intracranial tumors neighboring the precentral gyrus were selected for this pilot study. Conventional MRI and fMRI were obtained. Transcranial magnetic stimulation was performed using a MagPro X100 stimulator and a standard figure-of-eight coil positioned by an Adept Viper s850 robot. The fMRI activation/Ri-TMS response pattern were compared. In two cases, Ri-TMS was additionally compared to intraoperative direct electrical cortical stimulation. Maximal MEP response of the m. abductor digiti minimi was located in an area corresponding to the \"hand knob\" of the precentral gyrus for both hemispheres. Repeated Ri-TMS measurements showed a high reproducibility. Simultaneous registration of the MEP response for m. brachioradialis, m. abductor pollicis brevis, and m. abductor digiti minimi demonstrated individual peak areas of maximal MEP response for the individual muscle groups. Ri-TMS mapping was compared to the corresponding fMRI studies. The areas of maximal MEP response localized within the \"finger tapping\" activated areas by fMRI in all six individuals. Ri-TMS is suitable for high resolution non-invasive preoperative somatotopic mapping of the motor cortex. Ri-TMS may help in the planning of neurosurgical procedures and may be directly used in navigation systems."],["dc.description.sponsorship","EC [MEST-CT-2004-504193]"],["dc.identifier.doi","10.1007/s00701-009-0565-1"],["dc.identifier.isi","000274199900024"],["dc.identifier.pmid","19943069"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20575"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0001-6268"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Robot-assisted image-guided transcranial magnetic stimulation for somatotopic mapping of the motor cortex: a clinical pilot study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1427"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","1434"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Neulen, Axel"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Pilgram-Pastor, Sara M."],["dc.contributor.author","Metz, Imke"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:54:37Z"],["dc.date.available","2018-11-07T08:54:37Z"],["dc.date.issued","2011"],["dc.description.abstract","Background Surgery for symptomatic sacral perineural cysts remains an issue of discussion. Assuming micro-communications between the cyst and thecal sac resulting in a valve mechanism and trapping of CSF as a pathomechanism, microsurgical fenestration from the cyst to the thecal sac was performed to achieve free CSF communication. Methods In 13 consecutive patients (10 female, 3 male), MRI revealed sacral perineural cysts and excluded other pathologies. Micro-communication between the thecal sac and the cysts was shown by delayed contrast filling of the cysts on postmyelographic CT. Surgical fenestration achieved free CSF communication between the thecal sac and cysts in all patients. The patient histories, follow-up examinations and self-assessment scales were analyzed. Symptoms at initial presentation included lumbosacral pain, pseudoradicular symptoms, genital pain and urinary dysfunction. Mean follow-up was 10.7 +/- 6.6 months. Findings Besides one CSF fistula, no surgical complications were observed. Five patients did not improve after surgery\\; in four of these cases multiple cysts were found, but small and promptly filling cysts remained untreated. Seven patients reported lasting benefit following surgery\\; three of these had single cysts, and all had cysts >1 cm. One patient initially benefited from cyst fenestration but experienced recurrent pain within 2 months postoperatively. Re-myelography revealed delayed contrast filling of the recurrent cyst\\; however, surgical revision did not lead to an improvement despite successful fenestration and collapse of the cyst revealed by postoperative imaging. Conclusions Microsurgical fenestration of sacral perineural cysts to the thecal sac is a surgical approach that has shown success in the treatment of lumbosacral pain, pseudoradicular symptoms, genital pain and urinary dysfunction associated with sacral perineural cysts. Our analysis, however, shows that mainly patients with singular large cysts benefit from this treatment."],["dc.identifier.doi","10.1007/s00701-011-1043-0"],["dc.identifier.isi","000292924700009"],["dc.identifier.pmid","21562735"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6644"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22710"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0001-6268"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Microsurgical fenestration of perineural cysts to the thecal sac at the level of the distal dural sleeve"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","441"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.bibliographiccitation.lastpage","449"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Puchner, Maximilian Josef Anton"],["dc.contributor.author","Lohmann, Frauke"],["dc.contributor.author","Schuetze, Michael"],["dc.contributor.author","Koll, Simone"],["dc.contributor.author","Ketter, Ralf"],["dc.contributor.author","Buchalla, Ruediger"],["dc.contributor.author","Rainov, Nikolai"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:38:45Z"],["dc.date.available","2018-11-07T08:38:45Z"],["dc.date.issued","2010"],["dc.description.abstract","Randomized phase III trials have shown significant improvement of survival 1, 2, and 3 years after implantation of 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) wafers for patients with newly diagnosed malignant glioma. But these studies and subsequent non-phase III studies have also shown risks associated with local chemotherapy within the central nervous system. The introduction of concomitant radiochemotherapy with temozolomide (TMZ) has later demonstrated a survival benefit in a phase III trial and has become the current treatment standard for newly diagnosed malignant glioma patients. Lately, this has resulted in clinical protocols combining local chemotherapy with BCNU wafers and concomitant radiochemotherapy with TMZ although this may carry the risk of increased toxicity. We have compiled the treatment experience of seven neurosurgical centers using implantation of carmustine wafers at primary surgery followed by 6 weeks of radiation therapy (59-60 Gy) and 75 mg/m(2)/day TMZ in patients with newly diagnosed glioblastoma followed by TMZ monochemotherapy. We have retrospectively analyzed the postoperative clinical course, occurrence and severity of adverse events, progression-free interval, and overall survival in 44 patients with newly diagnosed glioblastoma multiforme. All patients received multimodal treatment including tumor resection, BCNU wafer implantation, and concomitant radiochemotherapy. Of 44 patients (mean age 59 +/- 10.8 years) with glioblastoma who received Gliadel wafer at primary surgery, 28 patients (64%) had died, 16 patients (36%) were alive, and 15 patients showed no evidence of clinical or radiographic progression after a median follow-up of 15.6 months. At time of analysis of adverse events in this patient population, the median overall survival was 12.7 months and median progression-free survival was 7.0 months. Surgical, neurological, and medical adverse events were analyzed. Twenty-three patients (52%) experienced adverse events of any kind including complications that did not require treatment. Nineteen patients (43%) experienced grade 3 or grade 4 adverse events. Surgical complications included cerebral edema, healing abnormalities, cerebral spinal fluid leakage, meningitis, intracranial abscess, and hydrocephalus. Neurological adverse events included newly diagnosed seizures, alteration of mental status, and new neurological deficits. Medical complications were thromboembolic events (thrombosis, pulmonary embolism) and hematotoxicity. Combination of both treatment strategies, local chemotherapy with BCNU wafer and concomitant radiochemotherapy, appears attractive in aggressive multimodal treatment schedules and may utilize the sensitizing effect of TMZ and carmustine on MGMT and AGT on their respective drug resistance genes. Our data demonstrate that combination of local chemotherapy and concomitant radiochemotherapy carries a significant risk of toxicity that currently appears underestimated. Adverse events observed in this study appear similar to complication rates published in the phase III trials for BCNU wafer implantation followed by radiation therapy alone, but further add the toxicity of concomitant radiochemotherapy with systemic TMZ. Save use of a combined approach will require specific prevention strategies for multimodal treatments."],["dc.identifier.doi","10.1007/s10143-010-0280-7"],["dc.identifier.isi","000282843600013"],["dc.identifier.pmid","20706757"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5161"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18832"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0344-5607"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","First-line treatment of malignant glioma with carmustine implants followed by concomitant radiochemotherapy: a multicenter experience"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2241"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","2250"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Neulen, Axel"],["dc.contributor.author","Gutenberg, Angelika"],["dc.contributor.author","Takacs, Ildiko"],["dc.contributor.author","Weber, Gyoergy"],["dc.contributor.author","Wegmann, Juergen"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:50:27Z"],["dc.date.available","2018-11-07T08:50:27Z"],["dc.date.issued","2011"],["dc.description.abstract","Semisynthetic collagen matrices are promising duraplasty grafts with low risk of cerebrospinal fluid (CSF) fistulas, good tissue integration and minor foreign body reaction. The present study investigates the efficacy and biocompatibility of a novel semisynthetic bilayered collagen matrix (BCM, B. Braun Aesculap) as dural onlay graft for duraplasty. Thirty-four pigs underwent osteoclastic trepanation, excision of the dura, and placement of a cortical defect, followed by duraplasty using BCM, Suturable DuraGen (TM) (Integra Neuroscience), or periosteum. CSF tightness and intraoperative handling of the grafts were evaluated. Pigs were sacrificed after 1 and 6 months for histological analysis. BCM and DuraGen (TM) showed superior handling than periosteum with a trend for better adhesion to dura and CSF tightness for BCM. Periosteum, which was sutured unlike the synthetic grafts, had the highest intraoperative CSF tightness. Duraplasty time with periosteum was significantly higher (14.4 +/- 2.7 min) compared with BCM (2.8 +/- 0.8 min) or DuraGen (TM) (3.0 +/- 0.5 min). Tissue integration by fibroblast infiltration was observed after 1 month for all devices. More adhesions between graft and cortex were observed with DuraGen (TM) compared with BCM and periosteum. No relevant adhesions between leptomeninges and BCM were observed and all devices showed comparable lymphocytic reaction of the brain. All devices were completely integrated after 6 months. BCM and DuraGen (TM) showed a trend for an enhanced lymphocytic reaction of the brain parenchyma compared with periosteum. Implant rejection was not observed. Semisythetic collagen matrices are an attractive alternative in duraplasty due to their easy handling, lower surgical time, and high biocompatibility."],["dc.description.sponsorship","B. Braun Aesculap AG, Tuttlingen, Germany"],["dc.identifier.doi","10.1007/s00701-011-1059-5"],["dc.identifier.isi","000296083700019"],["dc.identifier.pmid","21739175"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21696"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0001-6268"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evaluation of efficacy and biocompatibility of a novel semisynthetic collagen matrix as a dural onlay graft in a large animal model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","611"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.lastpage","615"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Winkler, Peter A."],["dc.contributor.author","Schichor, Christian"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Boeckh-Behrens, Tobias"],["dc.contributor.author","Tonn, Joerg-Christian"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T08:45:40Z"],["dc.date.available","2018-11-07T08:45:40Z"],["dc.date.issued","2010"],["dc.description.abstract","OBJECTIVE: A spinal perimedullary arteriovenous fistula (PMAVF) is a direct fistula of one or more spinal arteries into the perimedullary venous network with reversed venous flow and subsequent venous congestion of the spinal cord. The therapeutic goal of surgery is to normalize the venous drainage by obliterating the fistula. Strictly ventral lesions typically require an anterior approach to ensure adequate exposure of the fistula as well and the preservation of the physiological blood supply to the spinal cord. CLINICAL PRESENTATION: We present a case of a ventral PMAVF at the level of T10 with feeders from the anterior spinal artery, caudally draining veins on the ventral spinal cord, and a dilated transmedullary vein filling cranially draining veins on the dorsal aspect of the spinal cord. TECHNIQUE: The dilated transmedullary vein was approached by a laminectomy. The vein was coagulated, and the gliotic channel was used to approach the ventral fistula site from the dorsal surface of the spinal cord. Complete obliteration of the fistula was achieved, and the preoperative neurological deficit improved. CONCLUSION: We conclude that transmedullarly draining veins offers a possible dorsal approach for the occlusion of some ventral PMAVFs, thus avoiding more complex anterior approaches to the ventral spinal cord."],["dc.identifier.doi","10.1227/01.NEU.0000365365.10977.48"],["dc.identifier.isi","000274795800044"],["dc.identifier.pmid","20173556"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20501"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0148-396X"],["dc.title","A Transmedullary Approach to Occlusion of a Ventral Perimedullary Arteriovenous Fistula of the Thoracic Spinal Cord"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Kim, Ella L."],["dc.contributor.author","Richter, Christoph"],["dc.contributor.author","Pilzak, Agatha A."],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Gunawan, Bastian"],["dc.contributor.author","Schmitz-Salue, Christoph"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T11:21:41Z"],["dc.date.available","2018-11-07T11:21:41Z"],["dc.date.issued","2009"],["dc.format.extent","918"],["dc.identifier.isi","000272974100197"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55834"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology"],["dc.relation.eventlocation","Yokohama, JAPAN"],["dc.relation.issn","1522-8517"],["dc.title","ESTABLISHMENT AND CHARACTERIZATION OF AN EXPERIMENTAL MODEL OF INVASIVE GLIOMA WITH HIGHLY RADIORESISTANT PHENOTYPE"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","655"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","661"],["dc.bibliographiccitation.volume","152"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Siam, Laila"],["dc.contributor.author","Larsen, Joerg"],["dc.contributor.author","Burger, Ralf"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.contributor.author","Bockermann, Volker"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:44:14Z"],["dc.date.available","2018-11-07T08:44:14Z"],["dc.date.issued","2010"],["dc.description.abstract","In contrast to other regions of the human spine, dorsal fixation with rods and pedicle screws is comparatively rarely performed in the cervical spine. Although this technique provides a higher mechanical strength than the more frequently used lateral mass screws, many surgeons fear the relatively high rate of misplacements. This higher incidence is mainly due to the complex vertebral anatomy in this spinal segment. For correct screw placement, the availability of an immediate and efficient intra-operative imaging tool to ascertain the accuracy of the pedicle screw hole position would be beneficial. We have previously investigated the usefulness of an intraspinal, specifically, intra-osseous ultrasound technique in the lumbar spine. In this study its accuracy as a means of controlling intrapedicular screw hole positioning has been evaluated in the cervical spine. An endovascular ultrasound transducer was used for the intra-luminal scanning of 54 pedicle screw holes in cadaveric human spine specimens. Twenty-three of these had been intentionally misplaced (cortex breached). The resulting image files were assessed by three investigators blinded to both the procedure and the corresponding CT findings. The investigators differentiated correctly between adequately and poorly placed pedicle screw holes in 96% of cases. False negatives and false positives both occurred in no more than 1.8% of cases. Intrapedicular ultrasonography of pedicle screw holes in the cervical spine is a promising technique for the intra-operative assessment of bore hole placement and may increase operative safety and postoperative outcome in posterior cervical fusion surgery."],["dc.identifier.doi","10.1007/s00701-009-0447-6"],["dc.identifier.isi","000275945600013"],["dc.identifier.pmid","19597760"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20152"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0001-6268"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Intra-osseous ultrasound for pedicle screw positioning in the subaxial cervical spine: an experimental study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Biochemical Pharmacology"],["dc.bibliographiccitation.lastpage","20"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Kim, Ella L."],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Deppert, Wolfgang R."],["dc.date.accessioned","2018-11-07T08:33:53Z"],["dc.date.available","2018-11-07T08:33:53Z"],["dc.date.issued","2009"],["dc.description.abstract","The tumor suppressor p53 controls a broad range of cellular responses. Induction of a transient (cell cycle arrest) or a permanent (senescence) block of cell proliferation, or the activation of cell death pathways in response to genotoxic stress comprise the major arms of the survival-death axis governed by p53. Due to these biological properties, inactivation of p53 is a crucial step in tumor development and progression, reflected by the high incidence of TP53 mutations in different types of human cancers. The remarkable potency of p53 in suppressing tumorigenic outgrowth has promoted the expectation that tumor cells expressing wild-type p53 (wtp53) should be more prone to elimination by cytotoxic treatments than tumor cells expressing mutant p53 (mutp53) with defunct wtp53 activities. However, recent findings yielded somewhat unexpected insights concerning the preponderance of the survival-promoting effects of wtp53 in cancer cells, a rather undesired property from the therapeutic point of view. In this commentary we will discuss the possibility that the developmentally established distinct patterns of wtp53 mediated responses in different tissues are an important factor in determining the ultimate outcome of cellular responses mediated by wtp53 in different types of tumor cells, with a particular focus on the divergent impact of wtp53 in malignant tumors of the central nervous system. We infer that a selective gain of pro-survival functions of wtp53 in cancer cells will confer a survival advantage that counteracts tumor therapy. (C) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.bcp.2008.08.030"],["dc.identifier.isi","261779500002"],["dc.identifier.pmid","18812169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17697"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0006-2952"],["dc.title","Wild-type p53 in cancer cells: When a guardian turns into a blackguard"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Richter, Christoph"],["dc.contributor.author","Kim, Ella L."],["dc.contributor.author","Pilzak, Agatha A."],["dc.contributor.author","Schmitz-Salue, Christoph"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T11:10:44Z"],["dc.date.available","2018-11-07T11:10:44Z"],["dc.date.issued","2008"],["dc.format.extent","905"],["dc.identifier.isi","000259854500533"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53272"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","13th Annual Meeting of the Society-for-Neuro-Oncology (SNO)"],["dc.relation.eventlocation","Las Vegas, NV"],["dc.relation.issn","1522-8517"],["dc.title","BRAIN TUMOUR-INITIATING STEM-LIKE CELLS IN ESTABLISHED GLIOMA CELL LINES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]