Kauffmann, Philipp

[["dc.bibliographiccitation.artnumber","189"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Molecular and Clinical Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Hoene, Georg"],["dc.contributor.author","Gruber, Rudolf"],["dc.contributor.author","Leonhard, Johanna"],["dc.contributor.author","Wiechens, Bernhard"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.date.accessioned","2021-08-12T07:46:07Z"],["dc.date.available","2021-08-12T07:46:07Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3892/mco.2021.2351"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88623"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","2049-9469"],["dc.relation.issn","2049-9450"],["dc.title","Combined quality of life and posttraumatic growth evaluation during follow‑up care of patients suffering from oral squamous cell carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Case Reports"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Geisenhainer, Katharina"],["dc.contributor.author","Klenke, Daniela"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Kurbad, Oliver"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schliephake, H."],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.date.accessioned","2022-02-01T10:32:02Z"],["dc.date.available","2022-02-01T10:32:02Z"],["dc.date.issued","2022"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1002/ccr3.5268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/99006"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","2050-0904"],["dc.relation.issn","2050-0904"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/4.0/"],["dc.title","Desmoid fibromatosis in the pharyngeal wall: A case report and literature review"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","jbm.a.37411"],["dc.bibliographiccitation.firstpage","1599"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Biomedical Materials Research Part A"],["dc.bibliographiccitation.lastpage","1615"],["dc.bibliographiccitation.volume","110"],["dc.contributor.affiliation","Behrens, Christina; 1\r\nDepartment of Oral and Maxillofacial Surgery\r\nGeorge‐Augusta‐University\r\nGöttingen Germany"],["dc.contributor.affiliation","Kauffmann, Philipp; 1\r\nDepartment of Oral and Maxillofacial Surgery\r\nGeorge‐Augusta‐University\r\nGöttingen Germany"],["dc.contributor.affiliation","von Hahn, Nikolaus; 1\r\nDepartment of Oral and Maxillofacial Surgery\r\nGeorge‐Augusta‐University\r\nGöttingen Germany"],["dc.contributor.affiliation","Giesecke, Ariane; 1\r\nDepartment of Oral and Maxillofacial Surgery\r\nGeorge‐Augusta‐University\r\nGöttingen Germany"],["dc.contributor.affiliation","Schirmer, Uwe; 2\r\nInstitute for Bioprocessing and Analytical Measurement Techniques\r\nHeiligenstadt Germany"],["dc.contributor.affiliation","Liefeith, Klaus; 2\r\nInstitute for Bioprocessing and Analytical Measurement Techniques\r\nHeiligenstadt Germany"],["dc.contributor.author","Behrens, Christina"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Hahn, Nikolaus"],["dc.contributor.author","Giesecke, Ariane"],["dc.contributor.author","Schirmer, Uwe"],["dc.contributor.author","Liefeith, Klaus"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2022-06-01T09:39:01Z"],["dc.date.available","2022-06-01T09:39:01Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:14:12Z"],["dc.description.abstract","Abstract\r\nThe aim of the present study was to establish a modular platform of poly‐L‐lysine‐heparin (PLL‐Hep) polyelectrolyte multilayer (PEM) coatings on titanium surfaces for dual growth factor delivery of recombinant human bone morphogenic protein 2 (rhBMP2) and recombinant human vascular endothelial growth factor 165 (rhVEGF165) in clinically relevant quantities. Release characteristics for both growth factors differed significantly depending on film architecture. rhBMP2 induced activation of alkaline phosphatase in C2C12 cells and proliferation of human mesenchymal stem cells (hMSCs). rhVEGF mediated induction of von Willebrand factor (vWF) in hMSCs and proliferation of human umbilical vein endothelial cells. Osteogenic and angiogenic effects were modified by variation in cross‐linking and architecture of the PEMs. By creating multilayer films with distinct zones, release characteristics and proportion of both growth factor delivery could be tuned and surface‐activity modified to enhance angiogenic or osteogenic function in various ways. In summary, the system provides a modular platform for growth factor delivery that allows for individual composition and accentuation of angiogenic and osteogenic surface properties."],["dc.description.sponsorship","German Research Foundation (DFG)"],["dc.identifier.doi","10.1002/jbm.a.37411"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108367"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.publisher","John Wiley & Sons, Inc."],["dc.relation.eissn","1552-4965"],["dc.relation.issn","1549-3296"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Development of a system of heparin multilayers on titanium surfaces for dual growth factor release"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1095"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Cranio-Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","1103"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Thiemann, Charlotte"],["dc.contributor.author","Schulz, Xenia"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Schlottig, Falk"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.date.accessioned","2018-11-07T10:11:07Z"],["dc.date.available","2018-11-07T10:11:07Z"],["dc.date.issued","2016"],["dc.description.abstract","The present study aimed to evaluate primary stability (PS) and osseointegration of dental implants in polylactide [70/30 poly(L-lactide-co-o, L-lactide); (PLDLA)1 modified bone in 30 Goettingen minipigs. Each animal received three implants per jaw quadrant. In a split -mouth design, one side of the maxilla and mandible was randomly allocated to the experimental treatment (PLDLA applied into the drill hole before implantation), while the contralateral sides served as intraindividual controls (no PLDLA applied). The required insertion torque and the implant stability quotient (ISQ) were measured during implantation. ISQ volume density (VD) of new bone formation (NBF), and the bone -implant contact (BIC) were evaluated at the end of the observation period (1, 3, 6, 12, and 24 months, respectively) in six animals each. Across all study groups, the PLDLA treatment resulted in a) a comparable insertion torque, b) an equivalent ISQ c) a reduced BIC, and d) a reduced VD of NBF, as opposed to the untreated controls. In conclusion, the PLDLA treatment did not affect the PS, but rather led to an impaired osseointegration, which was particularly strong in the compact mandibular bone, and decreased in the spongious maxillary bone. PLDLA induced anchoring in spongious bone should be evaluated in further investigations. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","Thommen Medical AG, Grenchen, Switzerland"],["dc.identifier.doi","10.1016/j.jcms.2016.05.025"],["dc.identifier.isi","000381322200029"],["dc.identifier.pmid","27346283"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39987"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Churchill Livingstone"],["dc.relation.issn","1878-4119"],["dc.relation.issn","1010-5182"],["dc.title","Primary stability and osseointegration of dental implants in polylactide modified bone - A pilot study in Goettingen minipigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1223"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","1234"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Goldstein, Jan"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Epple, Matthias"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-25T07:45:51Z"],["dc.date.available","2018-06-25T07:45:51Z"],["dc.date.issued","2018-04"],["dc.description.abstract","(1) Objectives: The aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts. (2) Materials and methods: Porous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds. (3) Results: The evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4 weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5–2.0 μg BMP2 combined with 50 ng VEGF165 over a period of 5 weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect. (4) Conclusions: The findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals. Clinical relevance The development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release."],["dc.identifier.doi","10.1007/s00784-017-2202-3"],["dc.identifier.pmid","28936783"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15134"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1436-3771"],["dc.title","Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers and organization of bone formation in ectopic sites"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","194760352096706"],["dc.bibliographiccitation.journal","CARTILAGE"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Altherr, Manuel"],["dc.contributor.author","Gelis, Thomas"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2021-04-14T08:31:21Z"],["dc.date.available","2021-04-14T08:31:21Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1177/1947603520967069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83568"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1947-6043"],["dc.relation.issn","1947-6035"],["dc.title","SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","International Journal of Implant Dentistry"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Stünkel, Robert"],["dc.contributor.author","Zeller, Alexander-Nicolai"],["dc.contributor.author","Bohne, Thomas"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Wedi, Edris"],["dc.contributor.author","Raschke, David"],["dc.contributor.author","Kauffmann, Philipp"],["dc.date.accessioned","2022-10-10T06:18:06Z"],["dc.date.available","2022-10-10T06:18:06Z"],["dc.date.issued","2022-10-06"],["dc.date.updated","2022-10-09T03:11:11Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Nowadays, 3D planning and static for dynamic aids play an increasing role in oral rehabilitation of the masticatory apparatus with dental implants. The aim of this study is to compare the accuracy of implant placement using a 3D-printed drilling guide and an intraoral real-time dynamic navigation system.\r\n \r\n \r\n Methods\r\n A total of 60 implants were placed on 12 partially edentulous lower jaw models. 30 were placed with pilot drilling guides, the other half with dynamic navigation (DENACAM®). In addition, implant placement in interdental gaps and free-end situations were investigated. Accuracy was assessed by cone-beam computed tomography (CBCT).\r\n \r\n \r\n Results\r\n Both systems achieved clinically acceptable results, yet more accurate results regarding the offset of implant base and tip in several spatial dimensions were achieved using drilling guides (each p < 0.05). With regard to angulation, real-time navigation was more precise (p = 0.0016). Its inaccuracy was 3°; the template-guided systems was 4.6°. Median horizontal deviation was 0.52 mm at base and 0.75 mm at tip using DENACAM®. When using the pilot drill guide, horizontal deviation was 0.34 mm in the median and at the tip by 0.59 mm. Regarding angulation, it was found that the closer the drill hole was to the system's marker, the better navigation performed. The template did not show this trend (p = 0.0043; and p = 0.0022).\r\n \r\n \r\n Conclusion\r\n Considering the limitations of an in vitro study, dynamic navigation can be used be a tool for reliable and accurate implantation. However, further clinical studies need to follow in order to provide an evidence-based recommendation for use in vivo."],["dc.identifier.citation","International Journal of Implant Dentistry. 2022 Oct 06;8(1):41"],["dc.identifier.doi","10.1186/s40729-022-00430-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116164"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Dental implants"],["dc.subject","Guided surgery"],["dc.subject","Stereotactic surgery"],["dc.subject","Referencing"],["dc.subject","Intraoral real-time navigation"],["dc.subject","Static templates"],["dc.subject","Implant accuracy"],["dc.title","Accuracy of intraoral real-time navigation versus static, CAD/CAM-manufactured pilot drilling guides in dental implant surgery: an in vitro study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","clr.13820"],["dc.bibliographiccitation.firstpage","1228"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Clinical Oral Implants Research"],["dc.bibliographiccitation.lastpage","1240"],["dc.bibliographiccitation.volume","32"],["dc.contributor.affiliation","Raschke, David; 1Department for Oral & Maxillofacial Surgery Universitätsmedizin Goettingen Goettingen Germany"],["dc.contributor.affiliation","Tröltzsch, Markus; 2Private Office Ansbach Germany & Department for Oral & Maxillofacial Surgery Universitätsmedizin Goettingen Goettingen Germany"],["dc.contributor.affiliation","Santander, Petra; 3Department of Orthodontics Universitätsmedizin Göttingen Goettingen Germany"],["dc.contributor.affiliation","Brockmeyer, Phillip; 1Department for Oral & Maxillofacial Surgery Universitätsmedizin Goettingen Goettingen Germany"],["dc.contributor.affiliation","Schliephake, Henning; 1Department for Oral & Maxillofacial Surgery Universitätsmedizin Goettingen Goettingen Germany"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Raschke, David"],["dc.contributor.author","Tröltzsch, Markus"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Brockmeyer, Phillip"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2021-09-01T06:42:53Z"],["dc.date.available","2021-09-01T06:42:53Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T09:20:33Z"],["dc.description.abstract","Abstract Aim To test the hypothesis that the use of rhBMP2 in established defects requires additional growth factors such as rhVEGF to accomplish effective bone repair. Materials and Methods Horizontal/vertical defects of 2 cm length and 1 cm height were created bilaterally in the alveolar crest of the maxillae of 18 minipigs together with the extraction of all premolar teeth and one molar tooth on both sides. After 3 months of healing, defects were augmented with 0.5 g particulate PDLLA/CaCO3 composite loaded with 400 µg rhBMP2/50 µg rhVEGF165 on one side and 800 µg rhBMP2 on the other in 12 test animals, whereas defects in six control animals were sham operated and left unfilled on one side and augmented with blank carriers on the other. After 4 and 13 weeks, the animals were evaluated each for area of new bone formation (mm²) and bone density (area %). Results Augmentations with carriers loaded with 800 g µrhBMP2 failed to induce significantly more bone than in the augmentations with unloaded carrier after 4 and 13 weeks (p = .1000, p = .381). Augmentations with carriers loaded with 400 µg rhBMP2 and 50 µg erhVEGF165 resulted in significantly increased bone formation after 13 weeks (p = .024) compared to blank carriers. Soft tissue in augmentations with combined rhBMP2/rhVEGF165 loading exhibited numerous microvessels compared to soft tissue in augmentations with rhBMP2. Conclusions It is concluded that effective bone regeneration in augmentations of established alveolar ridge defects may require the application of rhVEGF additionally to rhBMP2."],["dc.description.sponsorship","KLS MARTIN"],["dc.identifier.doi","10.1111/clr.13820"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89167"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1600-0501"],["dc.relation.issn","0905-7161"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","The use of rhBMP2 for augmentation of established horizontal/vertical defects may require additional use of rhVEGF to achieve significant bone regeneration: An in vivo experimental study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1618"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery"],["dc.bibliographiccitation.lastpage","1629"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Gruber, Rudolph"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Rau, Anna"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-25T07:48:54Z"],["dc.date.available","2018-06-25T07:48:54Z"],["dc.date.issued","2016-10"],["dc.description.abstract","To evaluate the efficacy of grafting materials in lateral and vertical ridge augmentations."],["dc.identifier.doi","10.1016/j.jcms.2016.07.028"],["dc.identifier.pmid","27622971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15135"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-4119"],["dc.title","Clinical efficacy of grafting materials in alveolar ridge augmentation: A systematic review"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Pathology: Clinical Research"],["dc.bibliographiccitation.lastpage","47"],["dc.bibliographiccitation.volume","8"],["dc.contributor.affiliation","Fichtner, Alexander; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Joost, Jasmin; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Brockmeyer, Philipp; 2\r\nDepartment of Oral and Maxillofacial Surgery\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Kauffmann, Philipp; 2\r\nDepartment of Oral and Maxillofacial Surgery\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Schliephake, Henning; 2\r\nDepartment of Oral and Maxillofacial Surgery\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Hammerstein‐Equord, Alexander; 3\r\nDepartment of Thoracic and Cardiovascular Surgery\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Kueffer, Stefan; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Urlaub, Henning; 4\r\nBioanalytical Mass Spectrometry Group\r\nMax Planck Institute for Biophysical Chemistry\r\nGöttingen Germany"],["dc.contributor.affiliation","Oellerich, Thomas; 6\r\nDepartment of Medicine II, Haematology/Oncology\r\nGoethe University\r\nFrankfurt Germany"],["dc.contributor.affiliation","Ströbel, Philipp; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Bohnenberger, Hanibal; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Bremmer, Felix; 1\r\nInstitute of Pathology\r\nUniversity Medical Centre Göttingen\r\nGöttingen Germany"],["dc.contributor.author","Richter, Annika"],["dc.contributor.author","Fichtner, Alexander"],["dc.contributor.author","Joost, Jasmin"],["dc.contributor.author","Brockmeyer, Philipp"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Hammerstein‐Equord, Alexander"],["dc.contributor.author","Kueffer, Stefan"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Oellerich, Thomas"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.date.accessioned","2021-12-01T09:23:20Z"],["dc.date.available","2021-12-01T09:23:20Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-20T23:05:20Z"],["dc.description.abstract","Abstract The differentiation between a pulmonary metastasis and a newly developed squamous cell carcinoma of the lung in patients with prior head and neck squamous cell carcinoma (HNSCC) is difficult due to a lack of biomarkers but is crucially important for the prognosis and therapy of the affected patient. By using high‐resolution mass spectrometry in combination with stable isotope labelling by amino acids in cell culture, we identified 379 proteins that are differentially expressed in squamous cell carcinomas of the lung and the head and neck. Of those, CAV1, CAV2, LGALS1, LGALS7, CK19, and UGDH were tested by immunohistochemistry on 194 tissue samples (98 lung and 96 HNSCCs). The combination of CAV1 and LGALS7 was able to distinguish the origin of the squamous cell carcinoma with high accuracy (area under the curve 0.876). This biomarker panel was tested on a cohort of 12 clinically classified lung tumours of unknown origin after HNSCC. Nine of those tumours were immunohistochemically classifiable."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1002/cjp2.244"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94624"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2056-4538"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]