Schmidt-Samoa, Carsten

[["dc.bibliographiccitation.firstpage","1298"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Cognitive Neuroscience"],["dc.bibliographiccitation.lastpage","1307"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Cabral-Calderin, Yuranny"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2018-11-07T09:55:29Z"],["dc.date.available","2018-11-07T09:55:29Z"],["dc.date.issued","2015"],["dc.description.abstract","When our brain is confronted with ambiguous visual stimuli, perception spontaneously alternates between different possible interpretations although the physical stimulus remains the same. Both alpha (8-12 Hz) and gamma (>30 Hz) oscillations have been reported to correlate with such spontaneous perceptual reversals. However, whether these oscillations play a causal role in triggering perceptual switches remains unknown. To address this question, we applied transcranial alternating current stimulation (tACS) over the posterior cortex of healthy human participants to boost alpha and gamma oscillations. At the same time, participants were reporting their percepts of an ambiguous structure-from-motion stimulus. We found that tACS in the gamma band (60 Hz) increased the number of spontaneous perceptual reversals, whereas no significant effect was found for tACS in alpha (10 Hz) and higher gamma (80 Hz) frequencies. Our results suggest a mechanistic role of gamma but not alpha oscillations in the resolution of perceptual ambiguity."],["dc.description.sponsorship","Herman and Lilly Schilling Foundation"],["dc.identifier.doi","10.1162/jocn_a_00781"],["dc.identifier.isi","000355418000003"],["dc.identifier.pmid","25603029"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36753"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mit Press"],["dc.relation.issn","1530-8898"],["dc.relation.issn","0898-929X"],["dc.title","Rhythmic gamma stimulation affects bistable perception"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","87"],["dc.bibliographiccitation.journal","Hearing Research"],["dc.bibliographiccitation.lastpage","99"],["dc.bibliographiccitation.volume","295"],["dc.contributor.author","Golm, Dennis"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Kroener-Herwig, Birgit"],["dc.date.accessioned","2018-11-07T09:30:12Z"],["dc.date.available","2018-11-07T09:30:12Z"],["dc.date.issued","2013"],["dc.description.abstract","Chronic tinnitus affects approximately 5% of the population. Severe distress due to the phantom noise is experienced by 20% of the tinnitus patients. This distress cannot be predicted by psychoacoustic features of the tinnitus. It is commonly assumed that negative cognitive emotional evaluation of the tinnitus and its expected consequences is a major factor that determines the impact of tinnitus-related distress. Models of tinnitus distress and recently conducted research propose differences in limbic, frontal and parietal processing between highly and low distressed tinnitus patients. An experimental paradigm using verbal material to stimulate cognitive emotional processing of tinnitus-related information was conducted. Age and sex matched highly (n = 16) and low (n = 16) distressed tinnitus patients and healthy controls (n = 16) underwent functional magnetic resonance imaging (fMRI) while sentences with neutral, negative or tinnitus-related content were presented. A random effects group analysis was performed on the basis of the general linear model. Tinnitus patients showed stronger activations to tinnitus-related sentences in comparison to neutral sentences than healthy controls in various limbic/emotion processing areas, such as the anterior cingulate cortex, midcingulate cortex, posterior cingulate cortex, retrosplenial cortex and insula and also in frontal areas. Highly and low distressed tinnitus patients differed in terms of activation of the left middle frontal gyrus. A connectivity analysis and correlational analysis between the predictors of the general linear model of relevant contrasts and tinnitus-related distress further supported the idea of a fronto-parietal-cingulate network, which seems to be more active in highly distressed tinnitus patients. This network may present an aspecific distress network. Based on the findings the left middle frontal gyrus and the right medial frontal gyrus are suggested as target regions for neuromodulatory approaches in the treatment of tinnitus. For future studies we recommend the use of idiosyncratic stimulus material. (C) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.heares.2012.03.003"],["dc.identifier.isi","000315557100011"],["dc.identifier.pmid","22445697"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31249"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1878-5891"],["dc.relation.issn","0378-5955"],["dc.title","Neural correlates of tinnitus related distress: An fMRI-study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","630"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","636"],["dc.bibliographiccitation.volume","259"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Neubieser, Katja"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Schmidt, Holger"],["dc.date.accessioned","2018-11-07T09:11:41Z"],["dc.date.available","2018-11-07T09:11:41Z"],["dc.date.issued","2012"],["dc.description.abstract","Presence of BB-specific antibodies in the cerebrospinal fluid (CSF) with evidence of their intrathecal production in conjunction with the white cell count in the CSF and typical clinical symptoms is the traditional diagnostic gold standard of Lyme neuroborreliosis (LNB). Few data are available on the CSF lactate concentration in European adults with the diagnosis of acute LNB. The objective of the study was to investigate the CSF changes during acute LNB. Routine CSF parameters [leukocyte count, protein, lactate and albumin concentrations, CSF/serum quotients of albumin (Q(Alb)), IgG, IgA and IgM, and oligoclonal IgG bands] and the Borrelia burgdorferi (BB)-specific antibody index were retrospectively studied in relation to the clinical presentation in patients diagnosed with acute LNB. A total of 118 patients with LNB were categorized into the following groups according to their symptoms at presentation; group 1: polyradiculoneuritis (Bannwarth's syndrome), group 2: isolated facial palsy and group 3: predominantly meningitic course of the disease. In addition to the CSF of patients with acute LNB, CSF of 19 patients with viral meningitis (VM) and 3 with neurolues (NL) were analyzed. There were 97 patients classified with definite LNB, and 21 as probable LNB. Neck stiffness and fever were reported by 15.3% of patients. Most of these patients were younger than 50 years. Polyradiculoneuritis was frequently found in patients older than 50 years. Lymphopleocytosis was found in all patients. Only 5 patients had a CSF lactate >= 3.5 mmol/l, and the mean CSF lactate level was not elevated (2.1 +/- A 0.6 mmol/l). The patients with definite LNB had significantly higher lactate levels than patients with probable LNB. Elevated lactate levels were accompanied by fever and headache. In the Reiber nomograms, intrathecal immunoglobulin synthesis was found for IgM in 70.2% followed by IgG in 19.5%. Isoelectric focussing detected an intrathecal IgG synthesis in 83 patients (70.3%). Elevated BB AIs in the CSF were found in 97 patients (82.2%). Patients with VM showed lower CSF protein concentration and CSF/serum quotients of albumin than LNB patients. In acute LNB, all patients had elevated cerebrospinal fluid (CSF) leukocyte counts. In contrast to infections by other bacteria, CSF lactate was lower than 3.5 mmol/l in all but 5 patients. The CSF findings did not differ between polyradiculoneuritis, facial palsy, and meningitis. The CSF in LNB patients strongly differed from CSF in VM patients with respect to protein concentration and the CSF/serum albumin quotient."],["dc.identifier.doi","10.1007/s00415-011-6221-8"],["dc.identifier.isi","000302489400004"],["dc.identifier.pmid","21898139"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26777"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Behavioral Medicine"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Golm, Dennis"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Kroener-Herwig, Birgit"],["dc.date.accessioned","2018-11-07T09:06:59Z"],["dc.date.available","2018-11-07T09:06:59Z"],["dc.date.issued","2012"],["dc.format.extent","S97"],["dc.identifier.isi","000209816000235"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25681"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","1532-7558"],["dc.relation.issn","1070-5503"],["dc.title","NEURAL CORRELATES OF TINNITUS ANNOYANCE AND ITS REDUCTION AFTER COGNITIVE-BEHAVIORAL TRAINING: RESULTS FROM AN EMOTIONAL STROOP TASK"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","10"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","18"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Groeschel, Sonja"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Becker, Lars"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Kastrup, Andreas"],["dc.date.accessioned","2018-11-07T09:25:40Z"],["dc.date.available","2018-11-07T09:25:40Z"],["dc.date.issued","2013"],["dc.description.abstract","In addition to a contralateral activation of the primary and secondary somatosensory cortices, peripheral sensory stimulation has been shown to elicit responses in the ipsilateral primary somatosensory cortex (SI). In particular, evidence is accumulating that processes of interhemispheric inhibition as depicted by negative blood oxygenation level dependent (BOLD) signal changes are part of somatosensory processes. The aim of the study was to analyze age-related differences in patterns of cerebral activation in the somatosensory system in general and processes of interhemispheric inhibition in particular. For this, a functional magnetic resonance imaging (fMRI) study was performed including 14 younger (mean age 23.3 0.9 years) and 13 healthy older participants (mean age 73.2 +/- 8.3 years). All subjects were scanned during peripheral electrical median nerve stimulation (40 Hz) to obtain BOLD responses in the somatosensory system. Moreover, the individual current perception threshold (CPT) as a quantitative measure of sensory function was determined in a separate psychophysical testing. Significant increases in BOLD signal across the entire group could be measured within the contralateral SI, in the bilateral secondary somatosensory cortex (SII), the contralateral supplementary motor area and the insula. Negative BOLD signal changes were delineated in ipsilateral SI/MI as well as in the ipsilateral thalamus and basal ganglia. After comparing the two groups, only the cortical deactivation in ipsilateral SI in the early stimulation phase as well as the activation in contralateral SI and SII in the late stimulation block remained as statistically significant differences between the two groups. The psychophysical experiments yielded a significant age-dependent effect of CPT change with less difference in the older group which is in line with the significantly smaller alterations in maximal BOLD signal change in the contra- and ipsilateral SI found between the two groups. Healthy aging seems to be associated with a decrease in intracerebral inhibition as reflected by smaller negative BOLD signal changes during fMRI tasks. This finding could constitute an important link between age-related neurophysiological changes and behavioral alterations in humans. (C) 2012 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2012.12.039"],["dc.identifier.isi","000316154400002"],["dc.identifier.pmid","23296182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30119"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1095-9572"],["dc.relation.issn","1053-8119"],["dc.title","Effects of age on negative BOLD signal changes in the primary somatosensory cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","94"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Cabral-Calderin, Yuranny"],["dc.contributor.author","Weinrich, Christiane Anne"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Poland, Eva"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2017-09-07T11:54:45Z"],["dc.date.available","2017-09-07T11:54:45Z"],["dc.date.issued","2016"],["dc.description.abstract","Transcranial alternating current stimulation (tACS) has emerged as a promising tool for manipulating ongoing brain oscillations. While previous studies demonstrated frequency-specific effects of tACS on diverse cognitive functions, its effect on neural activity remains poorly understood. Here we asked how tACS modulates regional fMRI blood oxygenation level dependent (BOLD) signal as a function of frequency, current strength, and task condition. TACS was applied over the posterior cortex of healthy human subjects while the BOLD signal was measured during rest or task conditions (visual perception, passive video viewing and motor task). TACS was applied in a blockwise manner at different frequencies (10, 16, 60 and 80 Hz). The strongest tACS effects on BOLD activity were observed with stimulation at alpha (10 Hz) and beta (16 Hz) frequency bands, while effects of tACS at the gamma range were rather modest. Specifically, we found that tACS at 16 Hz induced BOLD activity increase in fronto-parietal areas. Overall, tACS effects varied as a function of frequency and task, and were predominantly seen in regions that were not activated by the task. Also, the modulated regions were poorly predicted by current density modeling studies. Taken together, our results suggest that tACS does not necessarily exert its strongest effects in regions below the electrodes and that region specificity might be achieved with tACS due to varying susceptibility of brain regions to entrain to a given frequency. (C) 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.23016"],["dc.identifier.fs","618728"],["dc.identifier.gro","3141752"],["dc.identifier.isi","000369150500007"],["dc.identifier.pmid","26503692"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14044"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/680"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Hermann and Lilly Schilling Foundation"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1097-0193"],["dc.relation.issn","1065-9471"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Transcranial Alternating Current Stimulation Affects the BOLD Signal in a Frequency and Task-dependent Manner"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","547"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.lastpage","555"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Djukic, M."],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Nau, R."],["dc.contributor.author","von Steinbuechel, Nicole"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Schmidt, H."],["dc.date.accessioned","2018-11-07T08:57:47Z"],["dc.date.available","2018-11-07T08:57:47Z"],["dc.date.issued","2011"],["dc.description.abstract","Background and purpose: Studies addressing the diagnostic relevance of anti-Borrelia burgdorferi (BB) serum antibodies in patients with non-specific symptoms and suspected chronic Lyme neuroborreliosis (LNB) are scarce. Methods: In this study, we enrolled within 1 year 122 patients with suspected chronic LNB. One hundred and fourteen patients had previously tested positive for BB. All patients had previously received antibiotic treatment. Each patient received a clinical examination and measurement of BB-specific antibodies. The diagnosis of neuroborreliosis was made according to the national guidelines of the German Society of Neurology. Nine patients had acute borreliosis. One of the nine met the criteria of acute LNB. Of the remaining 113 patients, 85 patients underwent a lumbar puncture. Ten seronegative subjects without lumbar puncture were also considered. In 61.8% of these 95 patients the quality of life, of sleep, mood, and anxiety were assessed. Results: Of 95 patients, 25.3% had symptoms without a somatic cause or evidence of borreliosis, 38.9% had a well-defined illness unrelated to BB infection, and 29.5% suffered from symptoms without a detectable somatic cause, displaying antibodies against BB. Six patients were grouped as post-LNB syndrome. Most common symptoms in all categories were arthralgia, myalgia, dysaesthesia, depressive mood and chronic fatigue. Conclusion: Patients with persistent symptoms with elevated serum antibodies against BB but without signs of cerebrospinal fluid inflammation require further diagnostic examinations to exclude ongoing infection and to avoid co-infections and other treatable conditions (e.g. autoimmune diseases). One patient with acute LNB, who was treated with ceftriaxone for 3 weeks suffered from LNB with new headaches and persistent symptoms 6 months later. These data should encourage further studies with new experimental parameters."],["dc.identifier.doi","10.1111/j.1468-1331.2010.03229.x"],["dc.identifier.isi","000288503600007"],["dc.identifier.pmid","20977545"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23484"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1351-5101"],["dc.title","The diagnostic spectrum in patients with suspected chronic Lyme neuroborreliosis - the experience from one year of a university hospital's Lyme neuroborreliosis outpatients clinic"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","178"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuroforum"],["dc.bibliographiccitation.lastpage","189"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Wilke, Melanie"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.date.accessioned","2017-09-07T11:43:41Z"],["dc.date.available","2017-09-07T11:43:41Z"],["dc.date.issued","2012"],["dc.description.abstract","Räumlicher Neglect stellt eine schwerwiegende Konsequenz von Hirnläsionen dar und ist durch die perzeptuelle und motorische Vernachlässigung einer Raumhälfte gekennzeichnet. Die zu Neglect führenden Läsionen treten innerhalb verteilter Netzwerke auf, die sich sowohl aus kortikalen Arealen (z.B. fronto-parietalen) als auch aus subkortikalen Strukturen (z.B. dem thalamischen Pulvinar) zusammensetzen. Die Entwicklung effektiver therapeutischer Strategien setzt ein detailliertes Verständnis der wichtigen Knotenpunkte und ihrer Interaktionen voraus. Allerdings sind präzise Informationen dazu aus Patientenstudien, aufgrund der Größe und Variabilität der mit Neglect assoziierten Läsionen, oft nur schwer zu erhalten. Experimentelle Modelle, bei denen definierte Gehirnregionen systematisch inaktiviert werden können, stellen daher eine wichtige Ergänzung zu den klassischen Läsionsstudien dar. Neglect-Modelle wurden beispielsweise bei nicht-humanen Primaten mithilfe lokaler, reversibler pharmakologischer Inaktivierung entwickelt, sowie bei gesunden Probanden mithilfe nicht-invasiver Stimulations-/Inaktivierungsmethoden wie der transkraniellen Magnetstimulation. In diesem Artikel diskutieren wir Theorien zum räumlichen Neglect, insbesondere die des hemisphärischen Ungleichgewichtes, und ihre empirische Evidenz. Ein Fokus liegt dabei auf Ergebnissen aus funktionellen Bildgebungsstudien, welche die Auswirkungen lokaler Läsionen auf dynamische Netzwerkaktivität untersuchen."],["dc.identifier.doi","10.1515/nf-2012-0103"],["dc.identifier.gro","3151609"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8423"],["dc.language.iso","de"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","1868-856X"],["dc.title","Experimentelle Modelle für räumlichen Neglect (Studien in humanen und nicht-humanen Primaten)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","135"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","149"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Wilke, Melanie"],["dc.contributor.author","Schneider, Lukas"],["dc.contributor.author","Dominguez-Vargas, Adan-Ulises"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Miloserdov, Kristina"],["dc.contributor.author","Nazzal, Ahmad"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Cabral-Calderin, Yuranny"],["dc.contributor.author","Scherberger, Hansjörg"],["dc.contributor.author","Kagan, Igor"],["dc.contributor.author","Bähr, Mathias"],["dc.date.accessioned","2018-02-08T10:49:56Z"],["dc.date.available","2018-02-08T10:49:56Z"],["dc.date.issued","2018-02"],["dc.description.abstract","Expansion of the dorsal pulvinar in humans and its anatomical connectivity suggests its involvement in higher-order cognitive and visuomotor functions. We investigated visuomotor performance in a 31 year old patient (M.B.) with a lesion centered on the medial portion of the dorsal pulvinar (left > right) due to an atypical Sarcoidosis manifestation. Unlike lesions with a vascular etiology, the lesion of M.B. did not include primary sensory or motor thalamic nuclei. Thus, this patient gave us the exceedingly rare opportunity to study the contribution of the dorsal pulvinar to visuomotor behavior in a human without confounding losses in primary sensory or motor domains. We investigated reaching, saccade and visual decision making performance. Patient data in each task was compared to at least seven age matched healthy controls. While saccades were hypometric towards both hemifields, the patient did not show any spatial choice bias or perceptual deficits. At the same time, he exhibited reach and grasp difficulties, which shared features with both, parietal and cerebellar damage. In particular, he had problems to form a precision grip and exhibited reach deficits expressed in decreased accuracy, delayed initiation and prolonged movement durations. Reach deficits were similar in foveal and extrafoveal viewing conditions and in both visual hemifields but were stronger with the right hand. These results suggest that dorsal pulvinar function in humans goes beyond its subscribed role in visual cognition and is critical for the programming of voluntary actions with the hands."],["dc.identifier.doi","10.1016/j.cortex.2017.10.011"],["dc.identifier.pmid","29216478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/12057"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.doi","10.1016/j.cortex.2017.10.011"],["dc.relation.eissn","1973-8102"],["dc.relation.issn","1973-8102"],["dc.title","Reach and grasp deficits following damage to the dorsal pulvinar"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","590"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","596"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Polania, Rafael"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T08:58:08Z"],["dc.date.available","2018-11-07T08:58:08Z"],["dc.date.issued","2011"],["dc.description.abstract","Measurements of motor evoked potentials (MEPs) have shown that anodal and cathodal transcranial direct current stimulations (tDCS) have facilitatory or inhibitory effects on corticospinal excitability in the stimulated area of the primary motor cortex (M1). Here, we investigated the online effects of short periods of anodal and cathodal tDCS on human brain activity of healthy subjects and associated hemodynamics by concurrent blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) at 3 T. Using a block design, 20 s periods of tDCS at 1 rnA intensity over the left M1 altered with 20 s periods without tDCS. In different fMRI runs, the effect of anodal or cathodal tDCS was assessed at rest or during finger tapping. A control experiment was also performed, in which the electrodes were placed over the left and right occipito-temporo-parietal junction. Neither anodal nor cathodal tDCS over the M1 for 20 s stimulation duration induced a detectable BOLD signal change. However, in comparison to a voluntary finger tapping task without stimulation, anodal tDCS during finger tapping resulted in a decrease in the BOLD response in the supplementary motor area (SMA). Cathodal stimulation did not result in significant change in BOLD response in the SMA, however, a tendency toward decreased activity could be seen. In the control experiment neither cathodal nor anodal stimulation resulted in a significant change of BOLD signal during finger tapping in any brain area including SMA, PM, and M1. These findings demonstrate that the well-known polarity-dependent shifts in corticospinal excitability that have previously been demonstrated using measurements of MEPs after M1 stimulation are not paralleled by analogous changes in regional BOLD signal. This difference implies that the BOLD signal and measurements of MEPs probe diverse physiological mechanisms. The MEP amplitude reflects changes in transsynaptic excitability of large pyramidal neurons while the BOLD signal is a measure of net synaptic activity of all cortical neurons. (C) 2010 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2010.11.085"],["dc.identifier.isi","000287556200017"],["dc.identifier.pmid","21211569"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23575"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","Transcranial direct current stimulation over the primary motor cortex during fMRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]