Leip, Casper-Lennart

[["dc.bibliographiccitation.firstpage","1194"],["dc.bibliographiccitation.issue","16-17"],["dc.bibliographiccitation.journal","Clinical Biochemistry"],["dc.bibliographiccitation.lastpage","1200"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Leip, Casper-Lennart"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Burchardi, Hilmar"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Oellerich, Michael"],["dc.date.accessioned","2018-11-07T10:55:48Z"],["dc.date.available","2018-11-07T10:55:48Z"],["dc.date.issued","2007"],["dc.description.abstract","Objectives: The aim was to investigate the outcome MODS/MOF in critically ill patients with regard to early hepatic dysfunction. Methods: Thirty adult polytrauma patients admitted to the ICU, with ISS >= 16 were prospectively investigated. Real-time liver function was assessed using the MEGX test and arterial ketone body ratio (AKBR) 12-24 h after admittance to ICU, and on days 3, 5, 8, 12. Results: Six patients (19%) died between days 4 and 29. Non-survivors were older (64.2 vs. 31.5 years), had a significantly higher ISS (40.5 vs. 30; p=0.002) and MODS score (9.5 vs. 5; p=0.001) on admittance to the ICU than survivors. On day 3 MEGX values (31 vs. 71.3 mu g/L; p=0.001) and the AKBRs (0.6 vs. 1.3; p=0.001) were significantly lower in non-survivors than in survivors whereas IL-6 levels were significantly higher in the former group (519 vs. 61 mu g/L; p = 0.05). Conclusions: The MEGX test and AKBR are sensitive early indicators of hepatic dysfunction in severely injured polytrauma patients at risk for developing MODS/MOF. (C) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.clinbiochem.2007.06.013"],["dc.identifier.isi","000250605200004"],["dc.identifier.pmid","17707362"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49869"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0009-9120"],["dc.title","Real-time assessment of hepatic function is related to clinical outcome in critically ill patients after polytrauma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Chemistry"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Leip, C. L."],["dc.contributor.author","Burchardi, Hilmar"],["dc.contributor.author","Oellerich, M."],["dc.date.accessioned","2018-11-07T10:38:28Z"],["dc.date.available","2018-11-07T10:38:28Z"],["dc.date.issued","2003"],["dc.format.extent","A52"],["dc.identifier.isi","000183088700162"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45817"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Clinical Chemistry"],["dc.publisher.place","Washington"],["dc.relation.conference","55th Annual Meeting of the American-Association-for-Clinical-Chemiatry"],["dc.relation.eventlocation","PHILADELPHIA, PENNSYLVANIA"],["dc.relation.issn","0009-9147"],["dc.title","Real-time assessment of hepatic function is related to clinical outcome in critically ill patients after polytrauma."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]