Horn, Sebastian

[["dc.bibliographiccitation.firstpage","50"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.lastpage","56"],["dc.bibliographiccitation.volume","92"],["dc.contributor.author","Zilles-Wegner, David"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Walliser, Karoline"],["dc.contributor.author","Saager, Leif"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Ernst, Mareike"],["dc.date.accessioned","2021-04-14T08:24:49Z"],["dc.date.available","2021-04-14T08:24:49Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00115-020-00960-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81434"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1433-0407"],["dc.relation.issn","0028-2804"],["dc.title","Elektrokonvulsionstherapie in der Schwangerschaft: Fallbericht und interdisziplinäre Behandlungsvorschläge"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","806"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Dalton Transactions"],["dc.bibliographiccitation.lastpage","816"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Falkenhagen, Jan P."],["dc.contributor.author","Limberg, Christian"],["dc.contributor.author","Demeshko, Serhiy"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Haumann, Michael"],["dc.contributor.author","Braun, Beatrice"],["dc.contributor.author","Mebs, Stefan"],["dc.date.accessioned","2018-11-07T09:47:16Z"],["dc.date.available","2018-11-07T09:47:16Z"],["dc.date.issued","2014"],["dc.description.abstract","The reaction between [(TPA) Fe(MeCN)(2)](OTf)(2) and [nBu(4)N](Cp MoO3) yields the novel tetranuclear complex [(TPA) Fe(mu-Cp MoO3)](2)(OTf)(2), 1, with a rectangular [Mo-O-Fe-O-](2) core containing high-spin iron(II) centres. 1 proved to be an efficient initiator/(pre)catalyst for the autoxidation of cis-cyclooctene with O-2 to give cyclooctene epoxide. To test, which features of 1 are essential in this regard, analogues with zinc(II) and cobalt(II) central atoms, namely [(TPA)Zn(Cp MoO3)](OTf), 3, and [(TPA) Co(Cp MoO3)](OTf), 4, were prepared, which proved to be inactive. The precursor compounds of 1, [(TPA) Fe(MeCN)(2)](OTf)(2) and [nBu(4)N](Cp MoO3) as well as Cp-2 Mo2O5, were found to be inactive, too. Reactivity studies in the absence of cyclooctene revealed that 1 reacts both with O-2 and PhIO via loss of the Cp ligands to give the triflate salt 2 of the known cation [((TPA)Fe)(2)(mu-O)(mu-MoO4)](2+). The cobalt analogue 4 reacts with O-2 in a different way yielding [((TPA)Co)(2)(mu-Mo2O8)](OTf)(2), 5, featuring a Mo2O84- structural unit which is novel in coordination chemistry. The compound [(TPA) Fe(mu-MoO4)](2), 6, being related to 1, but lacking Cp ligands failed to trigger autoxidation of cyclooctene. However, initiation of autoxidation by Cp radicals was excluded via experiments including thermal dissociation of Cp-2 ."],["dc.identifier.doi","10.1039/c3dt52349g"],["dc.identifier.isi","000327894400052"],["dc.identifier.pmid","24154868"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35073"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1477-9234"],["dc.relation.issn","1477-9226"],["dc.title","Iron-molybdenum-oxo complexes as initiators for olefin autoxidation with O-2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","741"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Inorganic Chemistry"],["dc.bibliographiccitation.lastpage","748"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Havelius, Kajsa G. V."],["dc.contributor.author","Reschke, Stefan"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Doerlng, Alexander"],["dc.contributor.author","Niks, Dimitri"],["dc.contributor.author","Hille, Russ"],["dc.contributor.author","Schulzke, Carola"],["dc.contributor.author","Leimkuehler, Silke"],["dc.contributor.author","Haumann, Michael"],["dc.date.accessioned","2018-11-07T08:59:17Z"],["dc.date.available","2018-11-07T08:59:17Z"],["dc.date.issued","2011"],["dc.description.abstract","YedY from Escherichia coli is a new member of the sulfite oxidase family of molybdenum cofactor (Moco)-containing oxidoreductases. We investigated the atomic structure of the molybdenum site in YedY by X-ray absorption spectroscopy, in comparison to human sulfite oxidase (hSO) and to a Mo-IV model complex. The K-edge energy was indicative of Mo-V in YedY, in agreement with X- and Q-band electron paramagnetic resonance results, whereas the hSO protein contained Mo-VI. In YedY and hSO, molybdenum is coordinated by two sulfur ligands from the molybdopterin ligand of the Moco, one thiolate sulfur of a cysteine (average Mo-S bond length of similar to 2.4 angstrom), and one (axial) oxo ligand (Mo=O, similar to 1.7 angstrom). hSO contained a second oxo group at Mo as expected, but in YedY, two species in about a 1:1 ratio were found at the active site, corresponding to an equatorial Mo-OH bond (similar to 2.1 angstrom) or possibly to a shorter M-O- bond. Yet another oxygen (or nitrogen) at a similar to 2.6 angstrom distance to Mo in YedY was identified, which could originate from a water molecule in the substrate binding cavity or from an amino acid residue close to the molybdenum site, i.e., Glu104, that is replaced by a glycine in hSO, or Asn45. The addition of the poor substrate dimethyl sulfoxide to YedY left the molybdenum coordination unchanged at high pH. In contrast, we found indications that the better substrate trimethylamine N-oxide and the substrate analogue acetone were bound at a similar to 2.6 angstrom distance to the molybdenum, presumably replacing the equatorial oxygen ligand. These findings were used to interpret the recent crystal structure of YedY and bear implications for its catalytic mechanism."],["dc.identifier.doi","10.1021/ic101291j"],["dc.identifier.isi","000286688700011"],["dc.identifier.pmid","21190337"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23853"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","1520-510X"],["dc.relation.issn","0020-1669"],["dc.title","Structure of the Molybdenum Site in YedY, a Sulfite Oxidase Homologue from Escherichia coli"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","8940"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Dieks, Jana-K."],["dc.contributor.author","Jünemann, Laura"],["dc.contributor.author","Hensel, Kai O."],["dc.contributor.author","Bergmann, Charlotte"],["dc.contributor.author","Schmidt, Stefan"],["dc.contributor.author","Quast, Anja"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.contributor.author","Santander, Petra"],["dc.date.accessioned","2022-06-01T09:39:11Z"],["dc.date.available","2022-06-01T09:39:11Z"],["dc.date.issued","2022"],["dc.description.abstract","Head development is a surrogate for brain development in infants and is related to neurocognitive outcome. There is only limited knowledge on early extra-uterine head shape and size assessment in very preterm infants. Here, 26 very preterm infants with a mean gestational age of 29.1 ± 2.2 weeks and a mean birth weight of 1273.8 ± 427.7 g underwent serial stereophotogrammetric 3D head imaging in weekly intervals from birth to term-equivalent age. The main outcome was the longitudinal assessment of the ‘physiological’ preterm head development with cephalometric size (head circumference, cranial volume) and shape parameters (cranial index, cranial vault asymmetry index) according to chronological and postmenstrual age (PMA). Potential clinical risk factors for the development of an abnormal low cranial index (dolichocephaly) were analysed. In serial measurements of 26 infants, the estimated head volume (95% confidence interval) increased from 244 (226–263) cm 3 at 28 weeks PMA to 705 (688–721) cm 3 at 40 weeks PMA. Moderate or severe dolichocephaly occurred in 21/26 infants (80.8%). Cranial index decreased over time (72.4%; 70.7–74 95% confidence interval). Brachycephaly and plagiocephaly were uncommon. No risk factors for severe dolichocephaly were identified. Our study shows that early detection of head shape and size anomalies utilizing 3D stereophotogrammetry is feasible and safe even in very preterm infants < 1500 g and/or < 32 weeks. 3D stereophotogrammetry could be used for timely identification of infants at risk for head shape anomalies. No specific risk factors for head shape anomalies were identified, especially not mode and duration of respiratory support."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1038/s41598-022-12887-x"],["dc.identifier.pii","12887"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108408"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Stereophotogrammetry can feasibly assess ‘physiological’ longitudinal three-dimensional head development of very preterm infants from birth to term"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","481"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Antibiotics"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Tilkorn, Friederike K. M. T."],["dc.contributor.author","Frickmann, Hagen"],["dc.contributor.author","Simon, Isabel S."],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Zimmermann, Ortrud"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.date.accessioned","2020-08-06T06:04:43Z"],["dc.date.available","2020-08-06T06:04:43Z"],["dc.date.issued","2020"],["dc.description.abstract","Young children are frequently colonized with Clostridioides (C.) difficile. Depending on their resistance patterns, antibiotic treatment can facilitate gastrointestinal spreading in colonized individuals, potentially leading to transmission to others. C. difficile was isolated from stool samples from infants born in two hospitals in Göttingen and Darmstadt, Germany. All isolates were subjected to phenotypic antimicrobial resistance testing, PCR-based screening for toxin genes and mass spectrometry-based exclusion of ribotypes 027 and 176. Within an initial cohort of 324 neonates with a longitudinal survey of C. difficile, 137 strains were isolated from 48 individuals. Antimicrobial resistance was recorded against metronidazole in one (0.7%), erythromycin in 16 (11.7%) and moxifloxacin in 2 (1.5%) of the strains, whereas no resistance was observed against vancomycin (0.0%) or rifampicin (0.0%). Newly observed resistance against erythromycin in children with detection of previously completely sensitive isolates was reported for C. difficile isolates from 2 out of 48 children. In 20 children (42%), non-toxigenic strains were detected, and from 27 children (56%), toxigenic strains were isolated, while both toxigenic and non-toxigenic strains were recorded for 1 child (2%). Ribotypes 027 or 176 were not observed. In conclusion, the German C. difficile strains isolated from the children showed mild to moderate resistance with predominance of macrolide resistance, a substance class which is frequently applied in children. The observed switches to the dominance of macrolide-resistant isolates suggests likely selection of resistant C. difficile strains already in children"],["dc.identifier.doi","10.3390/antibiotics9080481"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17510"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67527"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2079-6382"],["dc.relation.issn","2079-6382"],["dc.relation.orgunit","Institut für Medizinische Mikrobiologie"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.gro","C. difficile"],["dc.subject.gro","Rifaximin"],["dc.title","Antimicrobial Resistance Patterns in Clostridioides difficile Strains Isolated from Neonates in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3646"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Global Change Biology"],["dc.bibliographiccitation.lastpage","3659"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Camenzind, Tessa"],["dc.contributor.author","Hempel, Stefan"],["dc.contributor.author","Homeier, Juergen"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Velescu, Andre"],["dc.contributor.author","Wilcke, Wolfgang"],["dc.contributor.author","Rillig, Matthias C."],["dc.date.accessioned","2018-11-07T09:32:21Z"],["dc.date.available","2018-11-07T09:32:21Z"],["dc.date.issued","2014"],["dc.description.abstract","Increased nitrogen (N) depositions expected in the future endanger the diversity and stability of ecosystems primarily limited by N, but also often co-limited by other nutrients like phosphorus (P). In this context a nutrient manipulation experiment (NUMEX) was set up in a tropical montane rainforest in southern Ecuador, an area identified as biodiversity hotspot. We examined impacts of elevated N and P availability on arbuscular mycorrhizal fungi (AMF), a group of obligate biotrophic plant symbionts with an important role in soil nutrient cycles. We tested the hypothesis that increased nutrient availability will reduce AMF abundance, reduce species richness and shift the AMF community toward lineages previously shown to be favored by fertilized conditions. NUMEX was designed as a full factorial randomized block design. Soil cores were taken after 2years of nutrient additions in plots located at 2000m above sea level. Roots were extracted and intraradical AMF abundance determined microscopically; the AMF community was analyzed by 454-pyrosequencing targeting the large subunit rDNA. We identified 74 operational taxonomic units (OTUs) with a large proportion of Diversisporales. N additions provoked a significant decrease in intraradical abundance, whereas AMF richness was reduced significantly by N and P additions, with the strongest effect in the combined treatment (39% fewer OTUs), mainly influencing rare species. We identified a differential effect on phylogenetic groups, with Diversisporales richness mainly reduced by N additions in contrast to Glomerales highly significantly affected solely by P. Regarding AMF community structure, we observed a compositional shift when analyzing presence/absence data following P additions. In conclusion, N and P additions in this ecosystem affect AMF abundance, but especially AMF species richness; these changes might influence plant community composition and productivity and by that various ecosystem processes."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [DFG FOR816]; Freie Universitat Berlin"],["dc.identifier.doi","10.1111/gcb.12618"],["dc.identifier.isi","000344375700009"],["dc.identifier.pmid","24764217"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31737"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2486"],["dc.relation.issn","1354-1013"],["dc.title","Nitrogen and phosphorus additions impact arbuscular mycorrhizal abundance and molecular diversity in a tropical montane forest"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","104908"],["dc.bibliographiccitation.journal","Early Human Development"],["dc.bibliographiccitation.volume","140"],["dc.contributor.author","Horn, Sebastian"],["dc.date.accessioned","2020-08-06T06:31:53Z"],["dc.date.available","2020-08-06T06:31:53Z"],["dc.date.issued","2019"],["dc.description.abstract","BACKGROUND:Head shape and head volume of preterm infants give important information on short- and long-term development. Three-dimensional (3D) assessment of a preterm infant's head would therefore provide more information than currently used two-dimensional methods. AIMS:To evaluate a contactless 3D imaging system to assess head shape and volume in preterm infants. METHODS:A protocol for 3D imaging and reconstruction of an infant's head with a portable stereophotogrammetric camera system was developed. It was validated on a manikin by comparison to an established stationary stereophotogrammetric device. Feasibility for clinical routine and 3D data analysis were assessed in six preterm infants. RESULTS:Ten 3D reconstructions from a manikin were done with ten images each taken from different angles. The accuracy of the 3D reconstruction was measured at the overlapping areas between two images. Comparing the portable to the stationary system, a high concordance was found for the 3D manikin head-reconstructions (mean difference 0.21 ± 0.03 mm). In preterm infants, digital evaluation of the head was proven to be feasible for head circumference (HC), cranial index and asymmetry indices. There was good concordance between manual and digital measurement of the HC (95% CI -0.85 to 0.38 mm). CONCLUSIONS:The portable camera system allowed fast and contactless 3D image capture of a preterm infant's head without any risk or interference with neonatal care. Together with a new software, this technique would allow more precise evaluation of head growth even in very preterm infants and thereby may improve their care and long-term outcome."],["dc.identifier.doi","10.1016/j.earlhumdev.2019.104908"],["dc.identifier.pmid","31670175"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67532"],["dc.language.iso","en"],["dc.relation.eissn","1872-6232"],["dc.relation.issn","0378-3782"],["dc.title","Three-dimensional head shape acquisition in preterm infants - Translating an orthodontic imaging procedure into neonatal care"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","725"],["dc.bibliographiccitation.journal","Climate of the Past"],["dc.bibliographiccitation.lastpage","767"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Marchant, R."],["dc.contributor.author","Cleef, A."],["dc.contributor.author","Harrison, S. P."],["dc.contributor.author","Hooghiemstra, H."],["dc.contributor.author","Markgraf, V."],["dc.contributor.author","van Boxel, J."],["dc.contributor.author","Ager, T."],["dc.contributor.author","Almeida, L."],["dc.contributor.author","Anderson, R."],["dc.contributor.author","Baied, C."],["dc.contributor.author","Behling, Hermann"],["dc.contributor.author","Berrio, J. C."],["dc.contributor.author","Burbridge, R."],["dc.contributor.author","Björck, S."],["dc.contributor.author","Byrne, R."],["dc.contributor.author","Bush, M."],["dc.contributor.author","Duivenvoorden, J."],["dc.contributor.author","Flenley, J."],["dc.contributor.author","De Oliveira, P."],["dc.contributor.author","van Geel, B."],["dc.contributor.author","Graf, K."],["dc.contributor.author","Gosling, W. D."],["dc.contributor.author","Harbele, S."],["dc.contributor.author","van der Hammen, T."],["dc.contributor.author","Hansen, B."],["dc.contributor.author","Kuhry, P."],["dc.contributor.author","Ledru, M.-P."],["dc.contributor.author","Mayle, F."],["dc.contributor.author","Leyden, B."],["dc.contributor.author","Lozano-Garcia, S."],["dc.contributor.author","Melief, A. M."],["dc.contributor.author","Moreno, P."],["dc.contributor.author","Moar, N. T."],["dc.contributor.author","Prieto, A."],["dc.contributor.author","van Reenen, G."],["dc.contributor.author","Salgado-Labouriau, M."],["dc.contributor.author","Schäbitz, F."],["dc.contributor.author","Schreve-Brinkman, E. J."],["dc.contributor.author","Wille, M."],["dc.contributor.author","Horn, S."],["dc.date.accessioned","2019-07-10T08:13:18Z"],["dc.date.available","2019-07-10T08:13:18Z"],["dc.date.issued","2009"],["dc.description.abstract","The biomisation method is used to reconstruct Latin American vegetation at 6000±500 and 18 000±1000 radiocarbon years before present (14C yr BP) from pollen data. Tests using modern pollen data from 381 samples derived from 287 locations broadly reproduce potential natural vegetation. The strong temperature gradient associated with the Andes is recorded by a transition from high altitude cool grass/shrubland and cool mixed forest to mid-altitude cool temperate rain forest, to tropical dry, seasonal and rain forest at low altitudes. Reconstructed biomes from a number of sites do not match the potential vegetation due to local factors such as human impact, methodological artefacts and mechanisms of pollen representivity of the parent vegetation. At 6000±500 14C yr BP 255 samples are analysed from 127 sites. Differences between the modern and the 6000±500 14C yr BP reconstruction are comparatively small; change relative to the modern reconstruction are mainly to biomes characteristic of drier climate in the north of the region with a slight more mesic shift in the south. Cool temperate rain forest remains dominant in western South America. In northwestern South America a number of sites record transitions from tropical seasonal forest to tropical dry forest and tropical rain forest to tropical seasonal forest. Sites in Central America show a change in biome assignment, but to more mesic vegetation, indicative of greater plant available moisture, e.g. on the Yucatán peninsula sites record warm evergreen forest, replacing tropical dry forest and warm mixed forest presently recorded. At 18 000±1000 14C yr BP 61 samples from 34 sites record vegetation reflecting a generally cool and dry environment. Cool grass/shrubland is prevalent in southeast Brazil whereas Amazonian sites record tropical dry forest, warm temperate rain forest and tropical seasonal forest. Southernmost South America is dominated by cool grass/shrubland, a single site retains cool temperate rain forest indicating that forest was present at some locations at the LGM. Some sites in Central Mexico and lowland Colombia remain unchanged in the biome assignments of warm mixed forest and tropical dry forest respectively, although the affinities that these sites have to different biomes do change between 18 000±1000 14C yr BP and present. The \"unresponsive\" nature of these sites results from their location and the impact of local edaphic influence."],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5845"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61200"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","Pollen-based biome"],["dc.subject.ddc","570"],["dc.title","Pollen-based biome reconstructions for Latin America at 0, 6000 and 18 000 radiocarbon years ago"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","699"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Journal of Cancer"],["dc.bibliographiccitation.lastpage","704"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Horn, Sebastian"],["dc.date.accessioned","2020-08-06T06:30:48Z"],["dc.date.available","2020-08-06T06:30:48Z"],["dc.date.issued","2008"],["dc.description.abstract","MYCN amplification is a common feature of aggressive tumour biology in neuroblastoma. The MYCN transcription factor has been demonstrated to induce or repress expression of numerous genes. MicroRNAs (miRNA) are a recently discovered class of short RNAs that repress translation and promote mRNA degradation by sequence-specific interaction with mRNA. Here, we sought to analyse the role of MYCN in regulation of miRNA expression. Using a miRNA microarray containing 384 different miRNAs and a set of 160 miRNA real-time PCR assays to validate the microarray results, 7 miRNAs were identified that are induced by MYCN in vitro and are upregulated in primary neuroblastomas with MYCN amplification. Three of the seven miRNAs belong to the miR-106a and miR-17 clusters, which have previously been shown to be regulated by c-Myc. The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. Previous studies have reported miR-221 to be overexpressed in several other cancer entities, but its regulation has never before been associated with Myc. We present evidence of miRNA dysregulation in neuroblastoma. Additionally, we report miRNA induction to be a new mechanism of gene expression downregulation by MYCN."],["dc.identifier.doi","10.1002/ijc.23153"],["dc.identifier.pmid","17943719"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67530"],["dc.language.iso","en"],["dc.relation.eissn","1097-0215"],["dc.relation.issn","0020-7136"],["dc.title","MYCN regulates oncogenic MicroRNAs in neuroblastoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1219"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","American Journal of Clinical Nutrition"],["dc.bibliographiccitation.lastpage","1227"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Bommer, Christian"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Vollmer, Sebastian"],["dc.date.accessioned","2021-04-14T08:31:39Z"],["dc.date.available","2021-04-14T08:31:39Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1093/ajcn/nqaa196"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83667"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1938-3207"],["dc.relation.issn","0002-9165"],["dc.title","The effect of routine probiotics supplementation on preterm newborn health: a regression discontinuity analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]