Nguyen, Huong

[["dc.bibliographiccitation.artnumber","041014"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Physical Review X"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Abbott, B. P."],["dc.contributor.author","Abbott, R."],["dc.contributor.author","Abbott, T. D."],["dc.contributor.author","Abernathy, M. R."],["dc.contributor.author","Acernese, F."],["dc.contributor.author","Ackley, K."],["dc.contributor.author","Adams, C."],["dc.contributor.author","Adams, T."],["dc.contributor.author","Addesso, P."],["dc.contributor.author","Adhikari, R. X."],["dc.contributor.author","Chao, S."],["dc.contributor.author","Chen, Y."],["dc.contributor.author","Chung, S."],["dc.contributor.author","Dent, T."],["dc.contributor.author","Ghosh, S."],["dc.contributor.author","Gras, S."],["dc.contributor.author","Huang, S."],["dc.contributor.author","Karki, S."],["dc.contributor.author","Khan, S."],["dc.contributor.author","Munch, J."],["dc.contributor.author","Nguyen, T. T."],["dc.contributor.author","Oliver, M."],["dc.contributor.author","Qin, J."],["dc.contributor.author","Schmidt, J."],["dc.contributor.author","Singh, A."],["dc.contributor.author","Thomas, M."],["dc.contributor.author","Thomas, P."],["dc.contributor.author","Wang, H."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Westphal, T."],["dc.contributor.author","Zhang, M."],["dc.contributor.author","Zhang, Y."],["dc.contributor.author","Röver, C."],["dc.contributor.author","De, S."],["dc.date.accessioned","2016-11-04T09:18:28Z"],["dc.date.accessioned","2021-10-27T13:20:48Z"],["dc.date.available","2016-11-04T09:18:28Z"],["dc.date.available","2021-10-27T13:20:48Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1103/PhysRevX.6.041014"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13828"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91981"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2160-3308"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Improved analysis of GW150914 using a fully spin-precessing waveform model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1011109"],["dc.bibliographiccitation.journal","Frontiers in Cell and Developmental Biology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Nguyen, Huong; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Sokpor, Godwin; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Parichha, Arpan; \r\n5\r\nTata Institute of Fundamental Research, Mumbai, India"],["dc.contributor.affiliation","Pham, Linh; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Saikhedkar, Nidhi; \r\n5\r\nTata Institute of Fundamental Research, Mumbai, India"],["dc.contributor.affiliation","Xie, Yuanbin; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Ulmke, Pauline Antonie; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Rosenbusch, Joachim; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Pirouz, Mehdi; \r\n6\r\nMax Planck Institute for Multidisciplinary Sciences, Goettingen, Germany"],["dc.contributor.affiliation","Behr, Rüdiger; \r\n8\r\nGerman Primate Center-Leibniz Institute for Primate Research, Goettingen, Germany"],["dc.contributor.affiliation","Stoykova, Anastassia; \r\n6\r\nMax Planck Institute for Multidisciplinary Sciences, Goettingen, Germany"],["dc.contributor.affiliation","Brand-Saberi, Beate; \r\n4\r\nDepartment of Anatomy and Molecular Embryology, Ruhr University Bochum, Bochum, Germany"],["dc.contributor.affiliation","Nguyen, Huu Phuc; \r\n3\r\nDepartment of Human Genetics, Ruhr University Bochum, Bochum, Germany"],["dc.contributor.affiliation","Staiger, Jochen F.; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Tole, Shubha; \r\n5\r\nTata Institute of Fundamental Research, Mumbai, India"],["dc.contributor.affiliation","Tuoc, Tran; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.author","Nguyen, Huong"],["dc.contributor.author","Sokpor, Godwin"],["dc.contributor.author","Parichha, Arpan"],["dc.contributor.author","Pham, Linh"],["dc.contributor.author","Saikhedkar, Nidhi"],["dc.contributor.author","Xie, Yuanbin"],["dc.contributor.author","Ulmke, Pauline Antonie"],["dc.contributor.author","Rosenbusch, Joachim"],["dc.contributor.author","Pirouz, Mehdi"],["dc.contributor.author","Behr, Rüdiger"],["dc.contributor.author","Tuoc, Tran"],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Brand-Saberi, Beate"],["dc.contributor.author","Nguyen, Huu Phuc"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Tole, Shubha"],["dc.date.accessioned","2022-11-01T10:17:17Z"],["dc.date.available","2022-11-01T10:17:17Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:12:49Z"],["dc.description.abstract","Early forebrain patterning entails the correct regional designation of the neuroepithelium, and appropriate specification, generation, and distribution of neural cells during brain development. Specific signaling and transcription factors are known to tightly regulate patterning of the dorsal telencephalon to afford proper structural/functional cortical arealization and morphogenesis. Nevertheless, whether and how changes of the chromatin structure link to the transcriptional program(s) that control cortical patterning remains elusive. Here, we report that the BAF chromatin remodeling complex regulates the spatiotemporal patterning of the mouse dorsal telencephalon. To determine whether and how the BAF complex regulates cortical patterning, we conditionally deleted the BAF complex scaffolding subunits BAF155 and BAF170 in the mouse dorsal telencephalic neuroepithelium. Morphological and cellular changes in the BAF mutant forebrain were examined using immunohistochemistry and\r\n in situ\r\n hybridization. RNA sequencing, Co-immunoprecipitation, and mass spectrometry were used to investigate the molecular basis of BAF complex involvement in forebrain patterning. We found that conditional ablation of BAF complex in the dorsal telencephalon neuroepithelium caused expansion of the cortical hem and medial cortex beyond their developmental boundaries. Consequently, the hippocampal primordium is not specified, the mediolateral cortical patterning is compromised, and the cortical identity is disturbed in the absence of BAF complex. The BAF complex was found to interact with the cortical hem suppressor LHX2. The BAF complex suppresses cortical hem fate to permit proper forebrain patterning. We provide evidence that BAF complex modulates mediolateral cortical patterning possibly by interacting with the transcription factor LHX2 to drive the LHX2-dependent transcriptional program essential for dorsal telencephalon patterning. Our data suggest a putative mechanistic synergy between BAF chromatin remodeling complex and LHX2 in regulating forebrain patterning and ontogeny."],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship"," National Institute of Diabetes and Digestive and Kidney Diseases http://dx.doi.org/10.13039/100000062"],["dc.identifier.doi","10.3389/fcell.2022.1011109"],["dc.identifier.pmid","36263009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116773"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-605"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2296-634X"],["dc.relation.issn","2296-634X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","64"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.lastpage","65"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Post, Heiner"],["dc.contributor.author","Nguyen, T."],["dc.contributor.author","von Lewinski, Dirk"],["dc.contributor.author","Lauterbach, Marcel A."],["dc.contributor.author","Doerge, Hilmar"],["dc.contributor.author","Pieske, Burkert M."],["dc.date.accessioned","2018-11-07T10:56:04Z"],["dc.date.available","2018-11-07T10:56:04Z"],["dc.date.issued","2005"],["dc.identifier.isi","000233987100251"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49926"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","27th Congress of the European-Society-of-Cardiology"],["dc.relation.eventlocation","Stockholm, SWEDEN"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","p38 MAP kinase and oxygen radicals mediate progressive right ventricular force decline after acute stretch"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Post, Heiner"],["dc.contributor.author","Nguyen, T."],["dc.contributor.author","Dorge, H."],["dc.contributor.author","von Lewinski, Dirk"],["dc.contributor.author","Sellin, Christian"],["dc.contributor.author","Pieske, Burkert M."],["dc.date.accessioned","2018-11-07T10:44:40Z"],["dc.date.available","2018-11-07T10:44:40Z"],["dc.date.issued","2004"],["dc.format.extent","268"],["dc.identifier.isi","000224783501442"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47320"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","77th Scientific Meeting of the American-Heart-Association"],["dc.relation.eventlocation","New Orleans, LA"],["dc.relation.issn","0009-7322"],["dc.title","p38 MAP kinase mediates progressive right ventricular force decline after acute stretch"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S87"],["dc.bibliographiccitation.journal","The Journal of Headache and Pain"],["dc.bibliographiccitation.lastpage","S88"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Nguyen, T. X."],["dc.contributor.author","Eckel, H."],["dc.contributor.author","Nguyen, T. T."],["dc.contributor.author","Argyrakis, A."],["dc.contributor.author","Saupp, K."],["dc.contributor.author","Pohl, Christian"],["dc.contributor.author","Liem, S. H."],["dc.contributor.author","Schlebusch, K. P."],["dc.date.accessioned","2018-11-07T08:38:37Z"],["dc.date.available","2018-11-07T08:38:37Z"],["dc.date.issued","2010"],["dc.identifier.isi","000208791900248"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18803"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Milan"],["dc.relation.issn","1129-2377"],["dc.relation.issn","1129-2369"],["dc.title","Obligatory use of the modern medicinal, complementary, integrated medicine for the effective, gentle fighting the medicine induced duration headaches"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","241102"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","116"],["dc.contributor.author","Abbott, B. P."],["dc.contributor.author","Abbott, R."],["dc.contributor.author","Abbott, T. D."],["dc.contributor.author","Abernathy, M. R."],["dc.contributor.author","Acernese, F."],["dc.contributor.author","Ackley, K."],["dc.contributor.author","Adams, C."],["dc.contributor.author","Adams, T."],["dc.contributor.author","Addesso, P."],["dc.contributor.author","Adhikari, R. X."],["dc.contributor.author","Chao, S."],["dc.contributor.author","Chen, Y."],["dc.contributor.author","Chung, S."],["dc.contributor.author","Dent, T."],["dc.contributor.author","Franco, S."],["dc.contributor.author","Fricke, T. T."],["dc.contributor.author","Ghosh, S."],["dc.contributor.author","Gras, S."],["dc.contributor.author","Huang, S."],["dc.contributor.author","Karki, S."],["dc.contributor.author","Khan, S."],["dc.contributor.author","Kim, C."],["dc.contributor.author","Munch, J."],["dc.contributor.author","Nguyen, T. T."],["dc.contributor.author","Oliver, M."],["dc.contributor.author","Qin, J."],["dc.contributor.author","Röver, C."],["dc.contributor.author","Schmidt, J."],["dc.contributor.author","Shah, S."],["dc.contributor.author","Singh, A."],["dc.contributor.author","Thomas, M."],["dc.contributor.author","Thomas, P."],["dc.contributor.author","Wang, H."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Westphal, T."],["dc.contributor.author","Zhang, M."],["dc.contributor.author","Zhang, Y."],["dc.date.accessioned","2016-06-16T20:22:30Z"],["dc.date.accessioned","2021-10-27T13:20:31Z"],["dc.date.available","2016-06-16T20:22:30Z"],["dc.date.available","2021-10-27T13:20:31Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1103/PhysRevLett.116.241102"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13362"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91969"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Properties of the Binary Black Hole Merger GW150914"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4618"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular Neurobiology"],["dc.bibliographiccitation.lastpage","4635"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Tuoc, Tran"],["dc.contributor.author","Dere, Ekrem"],["dc.contributor.author","Radyushkin, Konstantin"],["dc.contributor.author","Pham, Linh"],["dc.contributor.author","Nguyen, Huong"],["dc.contributor.author","Tonchev, Anton B."],["dc.contributor.author","Sun, Guoqiang"],["dc.contributor.author","Ronnenberg, Anja"],["dc.contributor.author","Shi, Yanhong"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Stoykova, Anastassia"],["dc.date.accessioned","2017-09-07T11:46:21Z"],["dc.date.available","2017-09-07T11:46:21Z"],["dc.date.issued","2016"],["dc.description.abstract","The BAF chromatin remodeling complex plays an essential role in brain development. However its function in postnatal neurogenesis in hippocampus is still unknown. Here, we show that in postnatal dentate gyrus (DG), the BAF170 subunit of the complex is expressed in radial glial-like (RGL) progenitors and in cell types involved in subsequent steps of adult neurogenesis including mature astrocytes. Conditional deletion of BAF170 during cortical late neurogenesis as well as during adult brain neurogenesis depletes the pool of RGL cells in DG, and promotes terminal astrocyte differentiation. These derangements are accompanied by distinct behavioral deficits, as reflected by an impaired accuracy of place responding in the Morris water maze test, during both hidden platform as well as reversal learning. Inducible deletion of BAF170 in DG during adult brain neurogenesis resulted in mild spatial learning deficits, having a more pronounced effect on spatial learning during the reversal test. These findings demonstrate involvement of BAF170-dependent chromatin remodeling in hippocampal neurogenesis and cognition and suggest a specific role of adult neurogenesis in DG in adaptive behavior."],["dc.identifier.doi","10.1007/s12035-016-9948-5"],["dc.identifier.gro","3150498"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14191"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7269"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","0893-7648"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Ablation of BAF170 in developing and postnatal dentate gyrus affects neural stem cell proliferation, differentiation, and learning"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1006274"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Bachmann, Christina"],["dc.contributor.author","Nguyen, Huong"],["dc.contributor.author","Rosenbusch, Joachim"],["dc.contributor.author","Pham, Linh"],["dc.contributor.author","Rabe, Tamara I."],["dc.contributor.author","Patwa, Megha"],["dc.contributor.author","Sokpor, Godwin"],["dc.contributor.author","Seong, Rho H."],["dc.contributor.author","Ashery-Padan, Ruth"],["dc.contributor.author","Mansouri, Ahmed"],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Tuoc, Tran"],["dc.date.accessioned","2018-11-07T10:09:05Z"],["dc.date.available","2018-11-07T10:09:05Z"],["dc.date.issued","2016"],["dc.description.abstract","Neurogenesis is a key developmental event through which neurons are generated from neural stem/progenitor cells. Chromatin remodeling BAF (mSWI/SNF) complexes have been reported to play essential roles in the neurogenesis of the central nervous system. However, whether BAF complexes are required for neuron generation in the olfactory system is unknown. Here, we identified onscBAF and ornBAF complexes, which are specifically present in olfactory neural stem cells (oNSCs) and olfactory receptor neurons (ORNs), respectively. We demonstrated that BAF155 subunit is highly expressed in both oNSCs and ORNs, whereas high expression of BAF170 subunit is observed only in ORNs. We report that conditional deletion of BAF155, a core subunit in both onscBAF and ornBAF complexes, causes impaired proliferation of oNSCs as well as defective maturation and axonogenesis of ORNs in the developing olfactory epithelium (OE), while the high expression of BAF170 is important for maturation of ORNs. Interestingly, in the absence of BAF complexes in BAF155/BAF170 double-conditional knockout mice (dcKO), OE is not specified. Mechanistically, BAF complex is required for normal activation of Pax6-dependent transcriptional activity in stem cells/progenitors of the OE. Our findings unveil a novel mechanism mediated by the mSWI/SNF complex in OE neurogenesis and development."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2016"],["dc.identifier.doi","10.1371/journal.pgen.1006274"],["dc.identifier.isi","000386069000012"],["dc.identifier.pmid","27611684"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13696"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39592"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1553-7404"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","38"],["dc.bibliographiccitation.journal","Science Advances"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Kerimoglu, Cemil"],["dc.contributor.author","Pham, Linh"],["dc.contributor.author","Tonchev, Anton B."],["dc.contributor.author","Sakib, M. Sadman"],["dc.contributor.author","Xie, Yuanbin"],["dc.contributor.author","Sokpor, Godwin"],["dc.contributor.author","Ulmke, Pauline Antonie"],["dc.contributor.author","Kaurani, Lalit"],["dc.contributor.author","Abbas, Eman"],["dc.contributor.author","Nguyen, Huong"],["dc.contributor.author","Tuoc, Tran"],["dc.date.accessioned","2021-10-01T09:58:33Z"],["dc.date.available","2021-10-01T09:58:33Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1126/sciadv.abc6792"],["dc.identifier.pmid","34524839"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90085"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/341"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","2375-2548"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.title","H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1317"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Cell Cycle"],["dc.bibliographiccitation.lastpage","1324"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Nguyen, Huong"],["dc.contributor.author","Sokpor, Godwin"],["dc.contributor.author","Pham, Linh"],["dc.contributor.author","Rosenbusch, Joachim"],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Tuoc, Tran"],["dc.date.accessioned","2018-11-07T10:20:16Z"],["dc.date.available","2018-11-07T10:20:16Z"],["dc.date.issued","2016"],["dc.description.abstract","The multi-subunit chromatin-remodeling SWI/SNF (known as BAF for Brg/Brm-associated factor) complexes play essential roles in development. Studies have shown that the loss of individual BAF subunits often affects local chromatin structure and specific transcriptional programs. However, we do not fully understand how BAF complexes function in development because no animal mutant had been engineered to lack entire multi-subunit BAF complexes. Importantly, we recently reported that double conditional knock-out (dcKO) of the BAF155 and BAF170 core subunits in mice abolished the presence of the other BAF subunits in the developing cortex. The generated dcKO mutant provides a novel and powerful tool for investigating how entire BAF complexes affect cortical development. Using this model, we found that BAF complexes globally control the key heterochromatin marks, H3K27me2 and -3, by directly modulating the enzymatic activity of the H3K27 demethylases, Utx and Jmjd3. Here, we present further insights into how the scaffolding ability of the BAF155 and BAF170 core subunits maintains the stability of BAF complexes in the forebrain and throughout the embryo during development. Furthermore, we show that the loss of BAF complexes in the above-described model up-regulates H3K27me3 and impairs forebrain development and embryogenesis. These findings improve our understanding of epigenetic mechanisms and their modulation by the chromatin-remodeling SWI/SNF complexes that control embryonic development."],["dc.identifier.doi","10.1080/15384101.2016.1160984"],["dc.identifier.isi","000378726100007"],["dc.identifier.pmid","26986003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41849"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1551-4005"],["dc.relation.issn","1538-4101"],["dc.title","Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]