Caliskan, Neva

[["dc.bibliographiccitation.firstpage","265"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Trends in Biochemical Sciences"],["dc.bibliographiccitation.lastpage","274"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Caliskan, Neva"],["dc.contributor.author","Peske, Frank"],["dc.contributor.author","Rodnina, Marina V."],["dc.date.accessioned","2017-09-07T11:44:25Z"],["dc.date.available","2017-09-07T11:44:25Z"],["dc.date.issued","2015"],["dc.description.abstract","Programmed -1 ribosomal frameshifting (-1PRF) is an mRNA recoding event commonly utilized by viruses and bacteria to increase the information content of their genomes. Recent results have implicated -1PRF in quality control of mRNA and DNA stability in eukaryotes. Biophysical experiments demonstrated that the ribosome changes the reading frame while attempting to move over a slippery sequence of the mRNA - when a roadblockformed by a folded downstream segment in the mRNA stalls the ribosome in a metastable conformational state. The efficiency of -1PRF is modulated not only by cis-regulatory elements in the mRNA but also by transacting factors such as proteins, miRNAs, and antibiotics. These recent results suggest a molecular mechanism and new important cellular roles for -1PRF."],["dc.identifier.doi","10.1016/j.tibs.2015.03.006"],["dc.identifier.gro","3141911"],["dc.identifier.isi","000354143900005"],["dc.identifier.pmid","25850333"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2444"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Max Planck Society; Deutsche Forschungsgemeinschaft"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0968-0004"],["dc.title","Changed in translation: mRNA recoding by-1 programmed ribosomal frameshifting"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361a"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.volume","116"],["dc.contributor.author","Bock, Lars V."],["dc.contributor.author","Caliskan, Neva"],["dc.contributor.author","Korniy, Natalia"],["dc.contributor.author","Peske, Frank"],["dc.contributor.author","Rodnina, Marina V."],["dc.contributor.author","Grubmüller, Helmut"],["dc.date.accessioned","2022-03-01T11:45:00Z"],["dc.date.available","2022-03-01T11:45:00Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.bpj.2018.11.1966"],["dc.identifier.pii","S0006349518332314"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103186"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0006-3495"],["dc.title","Thermodynamic Control of Ribosomal Frameshifting"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1619"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cell"],["dc.bibliographiccitation.lastpage","1631"],["dc.bibliographiccitation.volume","157"],["dc.contributor.author","Caliskan, Neva"],["dc.contributor.author","Katunin, Vladimir I."],["dc.contributor.author","Belardinelli, Riccardo"],["dc.contributor.author","Peske, Frank"],["dc.contributor.author","Rodnina, Marina V."],["dc.date.accessioned","2017-09-07T11:46:12Z"],["dc.date.available","2017-09-07T11:46:12Z"],["dc.date.issued","2014"],["dc.description.abstract","Programmed -1 ribosomal frameshifting (-1PRF) is an mRNA recoding event utilized by cells to enhance the information content of the genome and to regulate gene expression. The mechanism of -1PRF and its timing during translation elongation are unclear. Here, we identified the steps that govern -1PRF by following the stepwise movement of the ribosome through the frameshifting site of a model mRNA derived from the IBV 1a/1b gene in a reconstituted in vitro translation system from Escherichia coli. Frameshifting occurs at a late stage of translocation when the two tRNAs are bound to adjacent slippery sequence codons of the mRNA. The downstream pseudoknot in the mRNA impairs the closing movement of the 30S subunit head, the dissociation of EF-G, and the release of tRNA from the ribosome. The slippage of the ribosome into the -1 frame accelerates the completion of translocation, thereby further favoring translation in the new reading frame."],["dc.identifier.doi","10.1016/j.cell.2014.04.041"],["dc.identifier.gro","3142104"],["dc.identifier.isi","000340941900016"],["dc.identifier.pmid","24949973"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4589"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Deutsche Forschungsgemeinschaft [RO 2004/9-1, SFB860]"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1097-4172"],["dc.relation.issn","0092-8674"],["dc.title","Programmed-1 Frameshifting by Kinetic Partitioning during Impeded Translocation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","558.e4"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Molecular cell"],["dc.bibliographiccitation.lastpage","567.e4"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Caliskan, Neva"],["dc.date.accessioned","2018-01-17T12:54:00Z"],["dc.date.available","2018-01-17T12:54:00Z"],["dc.date.issued","2017-05-18"],["dc.description.abstract","Ribosome frameshifting during translation of bacterial dnaX can proceed via different routes, generating a variety of distinct polypeptides. Using kinetic experiments, we show that -1 frameshifting predominantly occurs during translocation of two tRNAs bound to the slippery sequence codons. This pathway depends on a stem-loop mRNA structure downstream of the slippery sequence and operates when aminoacyl-tRNAs are abundant. However, when aminoacyl-tRNAs are in short supply, the ribosome switches to an alternative frameshifting pathway that is independent of a stem-loop. Ribosome stalling at a vacant 0-frame A-site codon results in slippage of the P-site peptidyl-tRNA, allowing for -1-frame decoding. When the -1-frame aminoacyl-tRNA is lacking, the ribosomes switch into -2 frame. Quantitative mass spectrometry shows that the -2-frame product is synthesized in vivo. We suggest that switching between frameshifting routes may enrich gene expression at conditions of aminoacyl-tRNA limitation."],["dc.identifier.doi","10.1016/j.molcel.2017.04.023"],["dc.identifier.pmid","28525745"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11693"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.eissn","1097-4164"],["dc.title","Conditional Switch between Frameshifting Regimes upon Translation of dnaX mRNA"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","342"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Nature Structural & Molecular Biology"],["dc.bibliographiccitation.lastpage","348"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Belardinelli, Riccardo"],["dc.contributor.author","Sharma, Heena"],["dc.contributor.author","Caliskan, Neva"],["dc.contributor.author","Cunha, Carlos E. da"],["dc.contributor.author","Peske, Frank"],["dc.contributor.author","Wintermeyer, Wolfgang"],["dc.contributor.author","Rodnina, Marina V."],["dc.date.accessioned","2017-09-07T11:54:33Z"],["dc.date.available","2017-09-07T11:54:33Z"],["dc.date.issued","2016"],["dc.description.abstract","During translation elongation, ribosome translocation along an mRNA entails rotations of the ribosomal subunits, swiveling motions of the small subunit (SSU) head and stepwise movements of the tRNAs together with the mRNA. Here, we reconstructed the choreography of the collective motions of the Escherichia coli ribosome during translocation promoted by elongation factor EF-G, by recording the fluorescence signatures of nine different reporters placed on both ribosomal subunits, tRNA and mRNA. We captured an early forward swiveling of the SSU head taking place while the SSU body rotates in the opposite, clockwise direction. Backward swiveling of the SSU head starts upon tRNA translocation and continues until the post-translocation state is reached. This work places structures of translocation intermediates along a time axis and unravels principles of the motions of macromolecular machines."],["dc.identifier.doi","10.1038/nsmb.3193"],["dc.identifier.gro","3141703"],["dc.identifier.isi","000373658300012"],["dc.identifier.pmid","26999556"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/136"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1545-9985"],["dc.relation.issn","1545-9993"],["dc.title","Choreography of molecular movements during ribosome progression along mRNA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Bock, Lars V."],["dc.contributor.author","Caliskan, Neva"],["dc.contributor.author","Korniy, Natalia"],["dc.contributor.author","Peske, Frank"],["dc.contributor.author","Rodnina, Marina V."],["dc.contributor.author","Grubmüller, Helmut"],["dc.date.accessioned","2021-03-05T08:58:31Z"],["dc.date.available","2021-03-05T08:58:31Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1038/s41467-019-12648-x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80163"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-393"],["dc.relation.eissn","2041-1723"],["dc.title","Thermodynamic control of −1 programmed ribosomal frameshifting"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","8079"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","8089"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Matsumoto, Saki"],["dc.contributor.author","Caliskan, Neva"],["dc.contributor.author","Rodnina, Marina V."],["dc.contributor.author","Murata, Asako"],["dc.contributor.author","Nakatani, Kazuhiko"],["dc.date.accessioned","2022-03-01T11:46:49Z"],["dc.date.available","2022-03-01T11:46:49Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1093/nar/gky689"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103812"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1362-4962"],["dc.relation.issn","0305-1048"],["dc.title","Small synthetic molecule-stabilized RNA pseudoknot as an activator for –1 ribosomal frameshifting"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]