Schittkowski, Michael P.

[["dc.bibliographiccitation.artnumber","64"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Orphanet Journal of Rare Diseases"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Reinert, Marie-Christine"],["dc.contributor.author","Pacheu-Grau, David"],["dc.contributor.author","Catarino, Claudia B."],["dc.contributor.author","Klopstock, Thomas"],["dc.contributor.author","Ohlenbusch, Andreas"],["dc.contributor.author","Schittkowski, Michael Peter"],["dc.contributor.author","Wilichowski, Ekkehard"],["dc.contributor.author","Rehling, Peter"],["dc.contributor.author","Brockmann, Knut"],["dc.date.accessioned","2021-04-14T08:28:08Z"],["dc.date.available","2021-04-14T08:28:08Z"],["dc.date.issued","2021"],["dc.date.updated","2022-07-29T12:17:42Z"],["dc.description.abstract","Background Leber hereditary optic neuropathy (LHON) is the most common mitochondrial disorder and characterized by acute or subacute painless visual loss. Environmental factors reported to trigger visual loss in LHON mutation carriers include smoking, heavy intake of alcohol, raised intraocular pressure, and some drugs, including several carbonic anhydrase inhibitors. The antiepileptic drug sulthiame (STM) is effective especially in focal seizures, particularly in benign epilepsy of childhood with centrotemporal spikes, and widely used in pediatric epileptology. STM is a sulfonamide derivate and an inhibitor of mammalian carbonic anhydrase isoforms I–XIV. Results We describe two unrelated patients, an 8-year-old girl and an 11-year-old boy, with cryptogenic focal epilepsy, who suffered binocular (subject #1) or monocular (subject #2) visual loss in close temporal connection with starting antiepileptic pharmacotherapy with STM. In both subjects, visual loss was due to LHON. We used real-time respirometry in fibroblasts derived from LHON patients carrying the same mitochondrial mutations as our two subjects to investigate the effect of STM on oxidative phosphorylation. Oxygen consumption rate in fibroblasts from a healthy control was not impaired by STM compared with a vehicle control. In contrast, fibroblasts carrying the m.14484T>C or the m.3460G>A LHON mutation displayed a drastic reduction of the respiration rate when treated with STM compared to vehicle control. Conclusions Our observations point to a causal relationship between STM treatment and onset or worsening of visual failure in two subjects with LHON rather than pure coincidence. We conclude that antiepileptic medication with STM may pose a risk for visual loss in LHON mutation carriers and should be avoided in these patients."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","Orphanet Journal of Rare Diseases. 2021 Feb 04;16(1):64"],["dc.identifier.doi","10.1186/s13023-021-01690-y"],["dc.identifier.pmid","33541401"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17726"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82509"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/219"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/102"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | A06: Mitochondrienfunktion und -umsatz in Synapsen"],["dc.relation.eissn","1750-1172"],["dc.relation.workinggroup","RG Rehling (Mitochondrial Protein Biogenesis)"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Sulthiame"],["dc.subject","Carbonic anhydrase inhibitor"],["dc.subject","Adverse effects"],["dc.subject","Leber hereditary optic neuropathy"],["dc.subject","LHON"],["dc.subject","Oxygen consumption rate"],["dc.title","Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Deutsches Ärzteblatt"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Horn, Maren"],["dc.date.accessioned","2021-04-14T08:31:21Z"],["dc.date.available","2021-04-14T08:31:21Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3238/arztebl.2020.0808a"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83566"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1866-0452"],["dc.title","Treatment-refractory canaliculitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","487"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","British Journal of Ophthalmology"],["dc.bibliographiccitation.lastpage","493"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Guthoff, R. F."],["dc.date.accessioned","2018-11-07T08:44:21Z"],["dc.date.available","2018-11-07T08:44:21Z"],["dc.date.issued","2010"],["dc.description.abstract","Introduction Congenital anophthalmos and microphthalmos are reported to occur in 1-20/100 000 newborn infants. The conditions may be characterised by associated pathology in the fellow eye when unilateral disease is present and/or by complex systemic anomalies. Methods We conducted a review of 75 patients with congenital anophthalmos or blind microphthalmos who were examined in our department from 1997 to 2008. Data on pregnancy, birth and family history were collected. Patients were screened for any pathology in the fellow eye in unilateral disease and for any systemic anomaly. Results Sixteen patients had blind unilateral microphthalmos. To date there has been only one case of bilateral microphthalmos. Congenital anophthalmos was unilateral in 38 and bilateral in 20 patients. Only one of the children had a positive family history for anophthalmos. None of the mothers had had problems in pregnancy or during delivery. There were more associated systemic findings in anophthalmic (50%) than in microphthalmic (17.6%) patients. Typically, the pathology was characterised by Goldenhar's syndrome, facial clefts and developmental cerebral anomalies. Four out of 16 patients with unilateral microphthalmos (25%) and 18 out of 38 patients with unilateral anophthalmos (47.4%) had anomalies in the fellow eye, predominantly coloboma, dermoid, sclerocornea and glaucoma. On account of this pathology in a single eye, two (12.5%) of the patients with unilateral microphthalmos and 13 (34.2%) of the patients with unilateral anophthalmos, as well as all 20 patients with bilateral anophthalmos, were classified as legally blind. Therefore the overall blindness rate was 17.6% in microphthalmos and 3.4 times higher (56.9%) in anophthalmos. Conclusions All children born with congenital anophthalmos or microphthalmos require a thorough clinical examination by an experienced ophthalmologist to rule out pathology in the fellow eye in unilateral disease and by a paediatrician to screen for any associated systemic anomalies."],["dc.identifier.doi","10.1136/bjo.2009.163436"],["dc.identifier.isi","000276841900020"],["dc.identifier.pmid","19822908"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6263"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20181"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","B M J Publishing Group"],["dc.relation.issn","0007-1161"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Systemic and ophthalmological anomalies in congenital anophthalmic or microphthalmic patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","01"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","63"],["dc.bibliographiccitation.volume","239"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Horn, Maren"],["dc.contributor.author","Naxer, Sabine"],["dc.date.accessioned","2022-04-01T10:02:44Z"],["dc.date.available","2022-04-01T10:02:44Z"],["dc.date.issued","2022"],["dc.description.abstract","Zusammenfassung Hintergrund Darstellung der klinischen Befunde der ableitenden Tränenwege bei Patienten mit kongenitalem klinischen Anophthalmus und funktionslosem Mikrophthalmus (MAC-Komplex). Methoden Retrospektive Studie von 207 konsekutiven Patienten, die zwischen 1998 und 2021 mindestens einmal mit hochhydrophilen selbstquellenden Expandern bei MAC operiert wurden. Das Tränenwegssystem wurde in Vollnarkose immer vor allen anderen operativen Maßnahmen sondiert und gespült. Ergebnisse 64 Patienten wurden wegen möglicher Fehldiagnosen aufgrund vorheriger Lid- oder Orbitachirurgie an anderer Stelle oder wegen fehlender Daten ausgeschlossen. Die Analyse umfasste daher 67 Mädchen und 76 Jungen im Alter zwischen 1 und 126 Monaten (medianes Alter: 5 Monate). 72 Patienten wiesen einen unilateralen und 42 einen bilateralen Anophthalmus auf, 24 einen unilateralen und 5 einen bilateralen Mikrophthalmus; somit standen 286 Augenhöhlen (davon 190 mit Pathologie) zur Beurteilung zur Verfügung. Bei einseitigen Fällen war das Tränenwegssystem auf der normalen Seite nie betroffen. Auf der anophthalmischen oder mikrophthalmischen Seite war das Tränenwegssystem nur in 68 Augenhöhlen (35,8%) unauffällig. Der häufigste Befund war eine Kanalikulusstenose (91 Augenhöhlen; 48%). Eine Stenose des Canaliculus communis wurde in 12 Augenhöhlen (6,3%) und eine Obstruktion des Ductus nasolacrimalis in 9 Augenhöhlen (4,7%) festgestellt. Es gab 4 Fälle von Aplasie beider Tränenpünktchen, andere Anomalien waren nicht auffällig. Beim einseitigen Anophthalmus ließ sich bei pathologischen Befunden der Tränenwegssondierung ein signifikanter Zusammenhang mit einer Lippen-Kiefer-Gaumen-Spalte feststellen, was in den 3 anderen Gruppen nicht der Fall war. Schlussfolgerungen Beim kongenitalen klinischen Anophthalmus ist das Tränensystem in bis zu 66,5% der Fälle betroffen, meist aufgrund einer Kanalikulusstenose. Auch wenn es keine eindeutigen Hinweise auf einen embryologischen Zusammenhang gibt, ist diese Assoziation sicher kein Zufallsbefund."],["dc.identifier.doi","10.1055/a-1721-2375"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105993"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1439-3999"],["dc.relation.issn","0023-2165"],["dc.title","Tränenwegsbefunde von 143 Kindern mit Mikrophthalmus-Anophthalmus-Komplex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","555"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","564"],["dc.bibliographiccitation.volume","228"],["dc.contributor.author","Naxer, S."],["dc.contributor.author","Behnes, Carl Ludwig"],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2018-11-07T08:55:20Z"],["dc.date.available","2018-11-07T08:55:20Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Amyloidosis is a disorder caused by a misfoulding of proteins. The deposition of these proteins in tissues and organs can affect the normal function of those tissues and organs. Materials and Methods: Two patients are presented and an overview over the so far published cases with a localised orbital amyloidosis is given. Results: The first case is a 50-year-old woman with progressive ptosis since half a year, progressive proptosis since three months and deterioration of motility and deviation of the left globe. The second case is a 68-year-old man with progressive ptosis since four years and with affection of the subtarsal conjunctiva of the right eye. Macroscopically a yellow-brown, gelatinous, easily crumbled material was seen during operation. Conclusion: the histological proof of amyloidosis can be made visually in intense unidirectional polarised light after congo red staining. This should be done in suspected cases every time. The orbita can also be involved in systemic forms of amyloidosis, so a systemic form should be excluded. The localised amyloidosis has no effect on the survival time in contrast to the systemic forms does have an effect. An untreated systemic form may be associuated with a prognosis of only 9 to 13 months."],["dc.identifier.doi","10.1055/s-0029-1245462"],["dc.identifier.isi","000291710100011"],["dc.identifier.pmid","20725885"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22877"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0023-2165"],["dc.title","Amyloidosis - a Rare Differential Diagnosis of an Orbital Tumour"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1194"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","1201"],["dc.bibliographiccitation.volume","237"],["dc.contributor.author","Karstädt, Nadja"],["dc.contributor.author","Crozier, Thomas A."],["dc.contributor.author","Horn, Maren"],["dc.contributor.author","Naxer, Sabine"],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2021-04-14T08:31:42Z"],["dc.date.available","2021-04-14T08:31:42Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1055/a-1260-3023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83688"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1439-3999"],["dc.relation.issn","0023-2165"],["dc.title","Postoperative Behaviour after Primary Strabismus Surgery in Children: Is There an Influence of Intraoperative Topical Anaesthesia?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","266"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","269"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Manousaridis, K."],["dc.contributor.author","Casper, Jochen"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Nizze, H."],["dc.contributor.author","Guthoff, R. F."],["dc.date.accessioned","2018-11-07T08:45:41Z"],["dc.date.available","2018-11-07T08:45:41Z"],["dc.date.issued","2010"],["dc.description.abstract","A 60-year-old man presented with left exophthalmos and deterioration in visual acuity of slow evolution. Bilateral orbital Erdheim-Chester disease was diagnosed. Systemic evaluation revealed a retroperitoneal fibrosis. Treatment with interferon-alpha followed, but bilateral compressive optic neuropathy with visual acuity deterioration and visual field defects evolved. Bilateral orbital decompression was performed."],["dc.identifier.doi","10.1007/s00347-009-2041-y"],["dc.identifier.isi","000275892900011"],["dc.identifier.pmid","19777245"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20506"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0941-293X"],["dc.title","Erdheim-Chester disease of the orbit with compressive optic neuropathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Ophthalmology"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2018-11-07T10:26:19Z"],["dc.date.available","2018-11-07T10:26:19Z"],["dc.date.issued","2017"],["dc.format.extent","E59"],["dc.identifier.doi","10.5301/ejo.5000895"],["dc.identifier.isi","000401747200011"],["dc.identifier.pmid","27791247"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43012"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wichtig Publishing"],["dc.relation.issn","1724-6016"],["dc.relation.issn","1120-6721"],["dc.title","The use of Mersilene mesh for tendon elongation in restrictive strabismus due to Graves disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","234"],["dc.contributor.author","Schittkowski, Michael P."],["dc.date.accessioned","2018-11-07T10:28:48Z"],["dc.date.available","2018-11-07T10:28:48Z"],["dc.date.issued","2017"],["dc.description.abstract","A case is presented of a 54-year old patient who had been treated 10 months previously with enucleation for a painful blind eye. This led to severe and chronic pain in the orbital region that did not respond to conventional pain management. However, a single 1.5ml injection of 96% ethanol led to almost complete resolution of pain for the followup period of 6 months. Orbital pain after enucleation or evisceration may originate from the implant itself, the prosthesis, the socket or the sinuses. Taking a careful medical history and an examination, including orbital scans, are necessary to decide on the correct differential diagnosis. If any pathology is excluded, one should keep in mind that phantom pain in the orbit seems common after removing an eye, more often when pain originating from the ball and/or headache was present before removal. The management of chronic pain in the orbital region has received little attention. Retrobulbar alcohol injection still has a place in modern ophthalmology, because it delivers effective pain relief in certain chronic conditions."],["dc.identifier.doi","10.1055/s-0042-118882"],["dc.identifier.isi","000397127600012"],["dc.identifier.pmid","28135743"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43505"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1439-3999"],["dc.relation.issn","0023-2165"],["dc.title","Alcohol Injection in a Patient with Chronic Orbital Pain after Enucleation - a Case Report and Review of the Literature"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","158"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","161"],["dc.bibliographiccitation.volume","229"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Guthoff, R. F."],["dc.contributor.author","Drewelow, B."],["dc.contributor.author","Wacke, R."],["dc.date.accessioned","2018-11-07T09:13:47Z"],["dc.date.available","2018-11-07T09:13:47Z"],["dc.date.issued","2012"],["dc.description.abstract","Purpose: The suitability of a high-hydrophilic osmotic self-inflating hydrogel expander consisting of a co-polymer of N-vinylpyrolidone and methyl methacrylate as a drug delivery system for antibiotics to prevent a postoperative infection was investigated in a laboratory setting. Methods: The dry expanders were incubated in a 0.3% solution of Ofloxacin or Tobramycin for 24 hours. The completely swollen expander had increased in volume from 0.3 mL to almost 3 mL (adsorbing 2.7 mL of the 0.3% solution, i.e.,8.1 mg of Ofloxacin or Tobramycin, respectively). Addressing the elimination of both antibiotics, the concentrations in 15 mL elution medium (simulating the volume of the orbit in a newborn baby) were measured after 0.25, 1, 2, 6, 24, 48 and 72 hours of elution. 0.9% sodium chloride (B. Braun Melsungen, Germany) was used as elution medium. To imitate fluid exchange due to blood perfusion in the surrounding tissue the medium was renewed after every sampling. For each substance 10 expanders were tested. Concentrations of antibiotic were determined by HPLC/UV for Ofloxacin and by using a specific fluorescence-polarisation immunoassay (Abbott TDx) for Tobramycin. Results: Mean concentrations of Ofloxacin at 0.25, 1, 2, 6, 24, 48 and 72 hours after beginning of the elution were 50.2, 46.8, 41.2, 75.4, 88.2, 46.2 and 19.1 mu g/mL, respectively. The cumulative amount of Ofloxacin eluted after 72 hours reached 68% of the loading dose. The corresponding mean concentrations of Tobramycin were 38.8, 48.5, 40.5, 69.8, 88.7, 119.3 and 71.6 mu g/mL. The cumulative eluted amount was 88%. Conclusions: The investigated hydrogel expanders soaked in 0.3% antibiotic solution can store and later on release sufficient amounts of Ofloxacin or Tobramycin to produce antimicrobial effective concentrations in vitro in the surrounding environment. This principle, when used in a clinical setting, might help to eliminate post-implantation infection which is one of the major complications in clinical use."],["dc.identifier.doi","10.1055/s-0031-1273457"],["dc.identifier.isi","000300615300009"],["dc.identifier.pmid","21847785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27249"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0023-2165"],["dc.title","Hydrogelexpander as Drug Delivery System for Antibiotics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]