Bittermann, Hans-Joachim

[["dc.bibliographiccitation.firstpage","1030"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","1033"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Gilliam, Frank S."],["dc.contributor.author","Steinhoff, B. J."],["dc.contributor.author","Bittermann, H. J."],["dc.contributor.author","Kuzniecky, R."],["dc.contributor.author","Faught, E."],["dc.contributor.author","Abou-Khalil, B."],["dc.date.accessioned","2018-11-07T09:11:13Z"],["dc.date.available","2018-11-07T09:11:13Z"],["dc.date.issued","2000"],["dc.description.abstract","The authors present 11 cases of idiopathic generalized epilepsy that began in adulthood at a mean age of 39 years. All patients had myoclonic jerks, five had absence seizures, and nine had infrequent generalized tonic-clonic seizures. A majority had a family history of seizures. EEG in all patients showed generalized epileptiform abnormalities, whereas neuroimaging and neurologic examination results were normal. This series appears to represent a previously undescribed idiopathic generalized epilepsy syndrome of adult myoclonic epilepsy."],["dc.description.sponsorship","NINDS NIH HHS [NS01794-01]"],["dc.identifier.isi","000089696500024"],["dc.identifier.pmid","11061264"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26669"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0028-3878"],["dc.title","Adult myoclonic epilepsy: A distinct syndrome of idiopathic generalized epilepsy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","206"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Ultraschall in der Medizin - European Journal of Ultrasound"],["dc.bibliographiccitation.lastpage","213"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Bartels, E."],["dc.contributor.author","Bittermann, H. J."],["dc.date.accessioned","2018-11-07T10:48:49Z"],["dc.date.available","2018-11-07T10:48:49Z"],["dc.date.issued","2004"],["dc.description.abstract","Aim: Contrast-enhanced transcranial triggered B-mode technology can be used to examine cerebral perfusion. However, this technique is still faced with methodological problems, especially the difficulty of overcoming the temporal bone window. The aim of the present study is to evaluate a deficit in cerebral perfusion after administration of the contrast agent SonoVue(TM) in acute stroke patients following decompressive craniectomy. Methods: Ten stroke patients (aged 39 to 59 years, mean age 57 years), in whom a decompressive craniectomy due to a malignant space-occupying infarction or intracerebral haemorrhage was performed, were examined with transcranial duplex sonography after application of the contrast agent SonoVue(TM). The transcranial examination was performed using transient response harmonic grey scale imaging with bolus kinetics based on a contrast harmonic imaging software with single-pulse transmission technology. The mechanical index was set at 1.0 to 1.1. Triggered images with pulsing intervals of 1000 ms were used for the evaluation of time intensity curves in several regions of interest. The sonographically imaged areas of hypoperfusion were compared with CT or MRI findings. Results: After injection of the contrast agent, the perfusion deficit could be detected ipsilaterally according to the affected vascular territory in the area of the MCA in 5 patients, in the area of ACA and MCA in 2 patients, in the area of the MCA, ACA and PCA in one patient and in the area of intracranial haemorrhage in 2 patients. The calculated average peak images corresponded precisely with the superimposed CT or MRI images in shape and size in all patients. Additionally, it was possible to observe several interesting contrast-induced phenomena in the cerebral parenchyma, as well as specific transit-time curve characteristics in the perfusion deficit area. Conclusions: Using contrast-enhanced transcranial duplex sonography with transient response harmonic imaging, it is possible to depict the perfusion deficit in cerebral microcirculation in patients following decompressive craniectomy and to obtain new insights into the pathophysiology of the hypoperfusion areas. Further studies should be done in stroke patients through the intact skull to standardise this method for early diagnosis of acute deficit in cerebral perfusion."],["dc.identifier.doi","10.1055/s-2004-813123"],["dc.identifier.isi","000221843600010"],["dc.identifier.pmid","15146361"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48287"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0172-4614"],["dc.title","Transcranial contrast Imaging of cerebral perfusion in stroke patients following decompressive craniectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","389"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","391"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Kele, H."],["dc.contributor.author","Verheggen, Raphaela"],["dc.contributor.author","Bittermann, H. J."],["dc.contributor.author","Reimers, Carl Detlev"],["dc.date.accessioned","2018-11-07T10:36:59Z"],["dc.date.available","2018-11-07T10:36:59Z"],["dc.date.issued","2003"],["dc.description.abstract","The authors compared ultrasonography with electrophysiology for the diagnosis of carpal tunnel syndrome (CTS) on 110 clinically affected wrists. An increased cross sectional area in the proximal carpal tunnel larger than 0.11 cm(2) in combination with compression signs on longitudinal scans proved to be highly predictive for CTS (sensitivity, 89.1%; specificity, 98.0%). Ultrasound was comparable to electrophysiology in the diagnosis of CTS, and in 35% of cases changes in morphology suggested a specific therapeutic strategy."],["dc.identifier.isi","000184712600023"],["dc.identifier.pmid","12913205"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45455"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0028-3878"],["dc.title","The potential value of ultrasonography in the evaluation of carpal tunnel syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","189"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Alcohol and Alcoholism"],["dc.bibliographiccitation.lastpage","192"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Bleich, Stefan"],["dc.contributor.author","Bleich, K."],["dc.contributor.author","Kropp, Silke"],["dc.contributor.author","Bittermann, H. J."],["dc.contributor.author","Degner, Detlef"],["dc.contributor.author","Sperling, W."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Kornhuber, Johannes"],["dc.date.accessioned","2018-11-07T09:04:41Z"],["dc.date.available","2018-11-07T09:04:41Z"],["dc.date.issued","2001"],["dc.description.abstract","Evidence from observational studies suggests that elevated levels of homocysteine are associated with an increased risk of cardiovascular diseases. We assessed whether moderate alcohol intake in healthy social drinkers, suggested to be cardioprotective according to the 'French paradox', influences the cardiovascular risk factor homocysteine. A total of 60 normal nourished subjects who had no evidence of Vascular disease or other risk factors for hyperhomocysteinaemia were assigned to receive mineral water or 30 g of alcohol per day (as beer, red wine or spirits) for a period of 6 weeks. Homocysteine levels of social drinkers, independent of which beverage was consumed, increased during the observation. We postulate that elevated levels of homocysteine in social drinkers with regular moderate alcohol intake are at risk of developing cardiovascular diseases, which contradicts the suggested cardioprotection of alcohol according to the 'French paradox'."],["dc.identifier.doi","10.1093/alcalc/36.3.189"],["dc.identifier.isi","000169318700002"],["dc.identifier.pmid","11373253"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25163"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0735-0414"],["dc.title","Moderate alcohol consumption in social drinkers raises plasma homocysteine levels: A contradiction to the 'French paradox'?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1371"],["dc.bibliographiccitation.issue","45"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","1374"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Reimers, Carl Detlev"],["dc.contributor.author","Kele, H."],["dc.contributor.author","Bittermann, H. J."],["dc.date.accessioned","2018-11-07T10:58:10Z"],["dc.date.available","2018-11-07T10:58:10Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1055/s-2000-8168"],["dc.identifier.isi","000165254500006"],["dc.identifier.pmid","11109426"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50417"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0012-0472"],["dc.title","The role of imaging in neuromuscular disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","499"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Ultrasound in Medicine"],["dc.bibliographiccitation.lastpage","507"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Bartels, E."],["dc.contributor.author","Bittermann, H. J."],["dc.date.accessioned","2018-11-07T10:03:07Z"],["dc.date.available","2018-11-07T10:03:07Z"],["dc.date.issued","2006"],["dc.description.abstract","Objective, The aim of this study was to evaluate a deficit in cerebral perfusion after administration of the contrast agent SonoVue (Bracco Altana Pharma, Konstanz, Germany) in patients with intracranial space-occupying lesions. Methods. We used transcranial duplex sonography to examine 10 healthy volunteers and 4 patients. Of the patients, one 55-year-old woman had an intracranial glioblastoma,one 54-year-old woman had an intracranial hemorrhage; and one 49-year-old woman and one 69-year-old man had a malignant middle cerebral artery infarction. A decompressive craniectomy was performed in the 2 patients with malignant middle cerebral artery infarction. Triggered images with pulsing intervals of 1000 milliseconds were used for the evaluation of time-intensity curves in several regions of interest. The mechanical index was set at 1.6; in patients with a craniectomy, the mechanical index was set at 1.1. Results. In all patients, the perfusion deficit could be recognized in the ipsilateral hemisphere. The superimposition of the sonographic images with those from computed tomography or magnetic resonance imaging showed a good correspondence in shape and size in patients with a craniectomy. In patients without a craniectomy, a rough correspondence with findings from magnetic resonance imaging or computed tomography could be recognized. Conclusions. By using contrast-enhanced transcranial duplex sonography, it is possible to image the perfusion deficit in cerebral microcirculation in patients with intracranial space-occupying lesions. These results should be confirmed by more pathologic cases and correlated with magnetic resonance imaging and other neuroimaging techniques. Additionally, further technical development in sonographic systems is necessary to improve the diagnostics of cerebral perfusion deficit."],["dc.identifier.isi","000236785600011"],["dc.identifier.pmid","16567439"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38381"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Inst Ultrasound Medicine"],["dc.relation.issn","0278-4297"],["dc.title","Transcranial contrast imaging of cerebral perfusion in patients with space-occupying intracranial lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3693"],["dc.bibliographiccitation.issue","7-8"],["dc.bibliographiccitation.journal","Transplantation Proceedings"],["dc.bibliographiccitation.lastpage","3694"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Blaschke, S."],["dc.contributor.author","Schettler, Volker"],["dc.contributor.author","Mayer, C."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Bittermann, H. J."],["dc.contributor.author","Grunewald, Rolf W."],["dc.date.accessioned","2018-11-07T08:31:07Z"],["dc.date.available","2018-11-07T08:31:07Z"],["dc.date.issued","2001"],["dc.identifier.doi","10.1016/S0041-1345(01)02506-4"],["dc.identifier.isi","000173143600266"],["dc.identifier.pmid","11750573"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17048"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","2001: A Transplant Odyssey Congress"],["dc.relation.eventlocation","ISTANBUL, TURKEY"],["dc.relation.issn","0041-1345"],["dc.title","Severe neurotoxicity of tacrolimus (FK506) after renal transplantation: Two case reports"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","947"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Epilepsia"],["dc.bibliographiccitation.lastpage","949"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Bittermann, H. J."],["dc.contributor.author","Wegerer, V."],["dc.contributor.author","Bleich, Stefan"],["dc.contributor.author","Steinhoff, B. J."],["dc.date.accessioned","2018-11-07T08:54:41Z"],["dc.date.available","2018-11-07T08:54:41Z"],["dc.date.issued","2001"],["dc.description.abstract","An adult patient had EEG occipital spike fixation off sensitivity and spontaneous occipital seizures due to perinatal asphyxia with bioccipital hemorrhage. EEG abnormalities consisted of repetitive posterior spikes that occurred when the eyes were closed and other conditions of fixation-off. Magnetic resonance imaging (MRI) documented severe posterior lesions with wallerian degeneration of the optic radiation. Electron capture detector single-photon emission computed tomography (ECD-SPECT) during the state of fixation-off showed regional hyperperfusion in the right posterior regions. We suggest that partial denervation of the primary visual cortex in this patient resulted in an increased cortical excitability and that the inhibitory effect of central vision and fixation leads to a suppression of spontaneous epileptic activity. This unusual symptomatic case may serve as a-model for the pathophysiology in the more often reported cases of idiopathic benign epilepsy syndrome of childhood."],["dc.identifier.doi","10.1046/j.1528-1157.2001.042007947.x"],["dc.identifier.isi","000170661000021"],["dc.identifier.pmid","11488898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22725"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0013-9580"],["dc.title","Fixation-off sensitivity in an adult with symptomatic occipital epilepsy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","75"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Epilepsy Research"],["dc.bibliographiccitation.lastpage","82"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Steinhoff, Bernhard J."],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Mursch, Kay"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Herrendorf, Gregor"],["dc.contributor.author","Bittermann, Hans-Joachim"],["dc.contributor.author","Felgenhauer, Klaus"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Markakis, Evangelos"],["dc.date.accessioned","2017-09-07T11:44:24Z"],["dc.date.available","2017-09-07T11:44:24Z"],["dc.date.issued","2002"],["dc.description.abstract","In the brain, S100 protein and neuron-specific enolase (NSE) are mainly found in glial cells and neurons, respectively. We investigated concentrations of S100 protein and NSE in cisternal cerebrospinal fluid obtained during implantation of foramen ovale electrodes in eight patients with temporal lobe epilepsy (TLE). In addition, the meningeal markers cystatin-C and β-trace as well as total protein were measured. Patients with trigeminal neuralgia (TN) undergoing glycerol rhizotomy served as controls. S100 protein and NSE levels ipsilateral to the site of seizure onset were significantly higher than in TN. Contralateral TLE values were also markedly but not significantly elevated. The meningeal markers cystatin-C and β-trace protein as well as total protein did not differ in TLE and TN. We conclude that interictal temporal lobe dysfunction corresponds with neuronal and glial marker elevations in the extracellular space and that site-specific elevations may predict the site of seizure origin biochemically."],["dc.identifier.doi","10.1016/s0920-1211(99)00026-1"],["dc.identifier.gro","3151649"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8466"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","0920-1211"],["dc.title","Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1196"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","1200"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Baudewig, Jürgen"],["dc.contributor.author","Bittermann, Hans-Joachim"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2018-11-07T08:54:18Z"],["dc.date.available","2018-11-07T08:54:18Z"],["dc.date.issued","2001"],["dc.description.abstract","Objectives: Attempts to localize the source of epileptic activity by linking electroencephalographic (EEG) abnormalities to blued oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) signal alterations art: hampered mainly by EEG distortions during MRI, subject motion, and unknown hemodynamic response characteristics. Methods: Using T2 -weighted echo-planar imaging at 2.0 T (2 s temporal resolution, 2x2x4 mm(3) spatial resolution). this work demonstrates strategies to alleviate some of these problems while studying a patient who had ideopathic generalized epilepsy with polyspike and slow-wave complexes. Results: Continuous EEG recordings during dynamic MRI (500 ms scanning, 1500 ms delay) and post-examination derivation of an EEG reference function for MRI analysis revealed positive BOLD MRI responses with temporal characteristics similar to those obtained fur functional challenges. Conclusions: The ability to map focal epileptic activity and/or associated cognitive processing provides new potential fur both epilepsy research and clinical patient management. (C) 2001 Elsevier Science Ireland Ltd. All rights I reserved."],["dc.identifier.doi","10.1016/S1388-2457(01)00562-4"],["dc.identifier.isi","000169789400006"],["dc.identifier.pmid","11516731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22638"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1388-2457"],["dc.title","Simultaneous EEG and functional MRI of epileptic activity: a case report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]