Hagemann, Johannes

[["dc.bibliographiccitation.firstpage","11552"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Optics Express"],["dc.bibliographiccitation.lastpage","11569"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Hagemann, Johannes"],["dc.contributor.author","Robisch, Anna-Lena"],["dc.contributor.author","Luke, D. R."],["dc.contributor.author","Homann, C."],["dc.contributor.author","Hohage, Thorsten"],["dc.contributor.author","Cloetens, Peter"],["dc.contributor.author","Suhonen, H."],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-09-07T11:46:15Z"],["dc.date.available","2017-09-07T11:46:15Z"],["dc.date.issued","2014"],["dc.description.abstract","We illustrate the errors inherent in the conventional empty beam correction of full field X-ray propagation imaging, i.e. the division of intensities in the detection plane measured with an object in the beam by the intensity pattern measured without the object, i.e. the empty beam intensity pattern. The error of this conventional approximation is controlled by the ratio of the source size to the smallest feature in the object, as is shown by numerical simulation. In a second step, we investigate how to overcome the flawed empty beam division by simultaneous reconstruction of the probing wavefront (probe) and of the object, based on measurements in several detection planes (multi-projection approach). The algorithmic scheme is demonstrated numerically and experimentally, using the defocus wavefront of the hard X-ray nanoprobe setup at the European Synchrotron Radiation Facility (ESRF). (C) 2014 Optical Society of America"],["dc.identifier.doi","10.1364/OE.22.011552"],["dc.identifier.fs","604845"],["dc.identifier.gro","3142122"],["dc.identifier.isi","000336957700017"],["dc.identifier.pmid","24921276"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12635"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4789"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: [SFB 755]"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1094-4087"],["dc.relation.orgunit","Institut für Numerische und Angewandte Mathematik"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.orgunit","Fakultät für Mathematik und Informatik"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.gro","x-ray imaging"],["dc.title","Reconstruction of wave front and object for inline holography from a set of detection planes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","98"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Annals of Hematology"],["dc.bibliographiccitation.lastpage","103"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Schuttrumpf, S."],["dc.contributor.author","Binder, L."],["dc.contributor.author","Hagemann, T."],["dc.contributor.author","Berkovic, D."],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Binder, Claudia"],["dc.date.accessioned","2018-11-07T10:41:02Z"],["dc.date.available","2018-11-07T10:41:02Z"],["dc.date.issued","2003"],["dc.description.abstract","Plasma concentrations of procalcitonin (PCT) have been shown to be elevated in bacterial and fungal infections. In contrast to C-reactive protein (CRP), PCT is not elevated in inflammations of noninfectious origin. Febrile inflammatory conditions are frequent in patients with hemato-oncological diseases. A reliable marker to discriminate infectious inflammations from drug-related and tumor-associated fever is still lacking. To evaluate the impact of PCT in this setting, PCT and CRP were prospectively measured in 95 febrile hemato-oncological patients. Infections could be identified in 40 of 95 patients: 38 of 95 had fever of unknown origin (FUO), 9 patients were suspected to suffer from drug-related fever, and 8 patients from tumor-associated fever. In the noninfection group (drug-related and tumor-associated fever), PCT levels were significantly lower than in patients with infections (P<0.001) or FUO (P<0.001). Differences were still highly significant comparing patients with suspected drug-related or tumor-associated fever alone with the infection or the FUO cohort. All eight patients with tumor-associated fever as well as eight of the nine patients with drug-related fever had PCT levels within the normal range (<0.5 mu g/l). CRP values only partially allowed discrimination between the various subgroups. Differences were significant between patients with drug-related fever and the infection (P=0.001) or FUO group (P=0.004). However, as CRP levels were far above the normal range also in the patients with drug-related fever, the significance of individual values was rather limited. In conclusion, PCT may provide useful additional information to assess the clinical significance of febrile conditions. PCT may facilitate the decision on when to initiate antimicrobial or cytotoxic therapy."],["dc.identifier.doi","10.1007/s00277-002-0584-y"],["dc.identifier.isi","000181574600007"],["dc.identifier.pmid","12601488"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46448"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-0584"],["dc.relation.issn","0939-5555"],["dc.title","Procalcitonin: a useful discriminator between febrile conditions of different origin in hemato-oncological patients?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","13973"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Optics Express"],["dc.bibliographiccitation.lastpage","13989"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Hagemann, Johannes"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-10-24T13:00:40Z"],["dc.date.accessioned","2021-10-11T11:35:06Z"],["dc.date.available","2017-10-24T13:00:40Z"],["dc.date.available","2021-10-11T11:35:06Z"],["dc.date.issued","2017"],["dc.description.abstract","We propose a reconstruction scheme for hard x-ray inline holography, a variant of propagation imaging, which is compatible with imaging conditions of partial (spatial) coherence. This is a relevant extension of current full-field phase contrast imaging, which requires full coherence. By the ability to reconstruct the coherent modes of the illumination (probe), as demonstrated here, the requirements of coherence filtering could be relaxed in many experimentally relevant settings. The proposed scheme is built on the mixed-state approach introduced in [Nature494, 68 (2013)], combined with multi-plane detection of extended wavefields [Opt. Commun.199, 65 (2001), Opt. Express22, 16571 (2014)]. Notably, the diversity necessary for the reconstruction is generated by acquiring measurements at different defocus positions of the detector. We show that we can recover the coherent mode structure and occupancy numbers of the partial coherent probe. Practically relevant quantities as the transversal coherence length can be computed from the reconstruction in a straightforward way."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1364/OE.25.013973"],["dc.identifier.gro","3142470"],["dc.identifier.pmid","28788984"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14797"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90727"],["dc.language","eng"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.notes.status","final"],["dc.relation.issn","1094-4087"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goedoc.uni-goettingen.de/licenses"],["dc.subject","X-ray imaging; Coherence; Phase retrieval"],["dc.subject.ddc","530"],["dc.subject.gro","x-ray optics"],["dc.subject.gro","x-ray imaging"],["dc.title","Reconstructing mode mixtures in the optical near-field"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","041109"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Applied Physics Letters"],["dc.bibliographiccitation.volume","113"],["dc.contributor.author","Hagemann, Johannes"],["dc.contributor.author","Töpperwien, Mareike"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2020-04-23T14:35:46Z"],["dc.date.available","2020-04-23T14:35:46Z"],["dc.date.issued","2018"],["dc.description.abstract","X-ray phase contrast imaging based on free space propagation relies on phase retrieval to obtain sharp images of micro- and nanoscale objects, with widespread applications in material science and biomedical research. For high resolution synchrotron experiments, phase retrieval is largely based on the single step reconstruction using the contrast transfer function approach (CTF), as introduced almost twenty years ago [Cloetens et al., Appl. Phys. Lett. 75, 2912 (1999)]. Notwithstanding its tremendous merits, this scheme makes stringent assumptions on the optical properties of the object, requiring, in particular, a weakly varying phase. In this work, we show how significant the loss in image quality becomes if these assumption are violated, and how phase retrieval can be easily improved by a simple scheme of alternating projections. Importantly, the approach demonstrated here uses the same input data and constraint sets as the conventional CTF-based phase retrieval, and is particularly well suited for the holographic regime."],["dc.identifier.doi","10.1063/1.5029927"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/64332"],["dc.language.iso","en"],["dc.relation.eissn","1077-3118"],["dc.relation.issn","0003-6951"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray imaging"],["dc.title","Phase retrieval for near-field X-ray imaging beyond linearisation or compact support"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3468"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Vaßholz, Malte"],["dc.contributor.author","Hoeppe, H. P."],["dc.contributor.author","Hagemann, Johannes"],["dc.contributor.author","Rosselló, J. M."],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Mettin, Robert"],["dc.contributor.author","Kurz, Thomas"],["dc.contributor.author","Schropp, A."],["dc.contributor.author","Seiboth, F."],["dc.contributor.author","Schroer, C. G."],["dc.contributor.author","Scholz, M."],["dc.contributor.author","Möller, J."],["dc.contributor.author","Hallmann, J."],["dc.contributor.author","Boesenberg, U."],["dc.contributor.author","Kim, C."],["dc.contributor.author","Zozulya, A."],["dc.contributor.author","Lu, W."],["dc.contributor.author","Shayduk, R."],["dc.contributor.author","Schaffer, R."],["dc.contributor.author","Madsen, A."],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2021-06-08T12:44:14Z"],["dc.date.available","2021-06-08T12:44:14Z"],["dc.date.issued","2021-06-08"],["dc.description.abstract","Cavitation bubbles can be seeded from a plasma following optical breakdown, by focusing an intense laser in water. The fast dynamics are associated with extreme states of gas and liquid, especially in the nascent state. This offers a unique setting to probe water and water vapor far-from equilibrium. However, current optical techniques cannot quantify these early states due to contrast and resolution limitations. X-ray holography with single X-ray free-electron laser pulses has now enabled a quasi-instantaneous high resolution structural probe with contrast proportional to the electron density of the object. In this work, we demonstrate cone-beam holographic flash imaging of laser-induced cavitation bubbles in water with nanofocused X-ray free-electron laser pulses. We quantify the spatial and temporal pressure distribution of the shockwave surrounding the expanding cavitation bubble at time delays shortly after seeding and compare the results to numerical simulations."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1038/s41467-021-23664-1"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87172"],["dc.relation.issn","2041-1723"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.rights","CC BY 4.0"],["dc.subject.gro","x-ray imaging"],["dc.title","Pump-probe X-ray holographic imaging of laser-induced cavitation bubbles with femtosecond FEL pulses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Biology of Reproduction"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Husen, B."],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Hagemann, T."],["dc.contributor.author","Einspanier, Almuth"],["dc.date.accessioned","2018-11-07T11:01:15Z"],["dc.date.available","2018-11-07T11:01:15Z"],["dc.date.issued","2000"],["dc.format.extent","260"],["dc.identifier.isi","000087862300456"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51105"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Study Reproduction"],["dc.publisher.place","Madison"],["dc.relation.issn","0006-3363"],["dc.title","Influence of progesterone, estradiol and relaxin on uterine differentiation in ovariectomized marmoset monkeys."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","157"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Breast Cancer Research and Treatment"],["dc.bibliographiccitation.lastpage","166"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Simon, Alfred"],["dc.contributor.author","Binder, L."],["dc.contributor.author","Hagemann, T."],["dc.contributor.author","Schulz, M."],["dc.contributor.author","Emons, G."],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Einspanier, Almuth"],["dc.date.accessioned","2018-11-07T10:45:48Z"],["dc.date.available","2018-11-07T10:45:48Z"],["dc.date.issued","2004"],["dc.description.abstract","Relaxin (RLX) is known to induce remodeling of benign stromal tissues through upregulation of matrix metalloproteases (MMPs). Recently, we could show that RLX also induces MMPs in breast cancer cells and enhances in vitro invasiveness. To investigate its potential role for progression of breast cancer in vivo, RLX serum concentrations were determined in 160 breast cancer patients during post-surgical follow-up. RLX concentrations in cancer patients were significantly higher than in a control population of healthy blood donors and patients with various other diseases (0.47 versus 0.29 ng/ml, p < 0.0001). There was a significant difference between patients with metastases (0.62 ng/ml) and those without (0.38 ng/ml, p < 0.0001). Overall survival was shorter in RLX-positive (>0.4 ng/ml) than in RLX-negative patients (p = 0.016). Cox regression analysis showed that RLX was not an independent variable, in contrast to metastatic disease and primary lymph node involvement. Taken together, the detection of elevated RLX concentrations especially in patients with metastases supports the assumption that there is a role for RLX in tissue remodeling during breast cancer progression."],["dc.identifier.doi","10.1023/B:BREA.0000041622.30169.16"],["dc.identifier.isi","000223914900005"],["dc.identifier.pmid","15377840"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47592"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Kluwer Academic Publ"],["dc.relation.issn","0167-6806"],["dc.title","Elevated concentrations of serum relaxin are associated with metastatic disease in breast cancer patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.seriesnr","24"],["dc.contributor.author","Hagemann, Johannes"],["dc.date.accessioned","2018-05-03T10:47:50Z"],["dc.date.available","2018-05-03T10:47:50Z"],["dc.date.issued","2017"],["dc.description.abstract","All images are flawed, no matter how good your lenses, mirrors etc. are. Especially in the hard X-ray regime it is challenging to manufacture high quality optics due to the weak interaction of multi-keV photons with matter. This is a tremendous challenge for obtaining high resolution quantitative X-ray microscopy images. In recent years lensless phase contrast imaging has become an alternative to classical absorptionbased imaging methods. Without any optics, the image is formed only by the free space propagation of the wave field. The actual image has to be formed posteriori by numerical reconstruction methods. Advanced phasing methods enable the experimentalist to recover a complex valued specimen from a single or a set of intensity measurement. This would be the ideal case - reality teaches us that there are no ideal imaging conditions. Describing, understanding and circumventing these non ideal imaging conditions and their effects on X-ray near-field holographic (NFH) imaging are the leitmotifs for this thesis. In NFH the non ideal conditions manifest themselves in the illuminating wave field or probe. The probe generally does not satisfy the canonical assumptions of fully coherent and monochromatic radiation emitted by a point source. The main results of this thesis are compiled as a collection of publications. An approach is shown to reconstruct the probe of a X-ray nano-focus setup by a series of measurements of the probe at varied Fresnel number. The following chapter presents a study concerning the reconstruction efficiency in terms of resolution for near- and far-field based lensless imaging. In the following, the reconstruction scheme for the probe is extended to incorporate the effects of partial coherence in the near field. This enables the recovery of the modal structure of the probe which yields a full description of its coherence properties. Giving up the assumption of temporal stability due to the stochastic pulses, delivered by X-ray free electron lasers, the reconstruction of probe and specimen must be achieved from a single shot. A suitable scheme for this purpose is proposed in this work."],["dc.format.extent","X, 138"],["dc.identifier.doi","10.17875/gup2017-1055"],["dc.identifier.isbn","978-3-86395-332-4"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?univerlag-isbn-978-3-86395-332-4"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/14536"],["dc.identifier.urn","urn:nbn:de:gbv:7-isbn-978-3-86395-332-4-9"],["dc.language.iso","en"],["dc.notes.intern","TASK GROB-550"],["dc.notes.status","zu prüfen"],["dc.publisher","Universitätsverlag Göttingen"],["dc.publisher.place","Göttingen"],["dc.relation.crisseries","Göttingen Series in X-Ray Physics"],["dc.relation.ispartofseries","Göttingen Series in X-ray Physics; 24"],["dc.rights","CC BY-SA 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by-sa/4.0/deed.de"],["dc.title","X-Ray Near-Field Holography: Beyond Idealized Assumptions of the Probe"],["dc.type","thesis"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","766"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","DNA and Cell Biology"],["dc.bibliographiccitation.lastpage","776"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Hagemann, T."],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Binder, L."],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Grimshaw, M. J."],["dc.date.accessioned","2018-11-07T10:54:33Z"],["dc.date.available","2018-11-07T10:54:33Z"],["dc.date.issued","2005"],["dc.description.abstract","There is increased staining of endothelins (ET-1, - 2, and - 3) and receptors (ET-RA and - RB) in invasive breast tumors compared to nonneoplastic tissue, and ETs stimulate MCF-7 cell invasion in vitro. We analyzed ET-stimulation of benign and transformed mammary epithelial cells, and whether expression of ETs is sufficient to induce invasiveness. In breast cancer patient serum, ET-1 was increased in those patients with lymph node metastases compared to those with no lymph node involvement; ETs, however, had no mitogenic effect on breast tumor cell lines in vitro. The benign mammary epithelial cell line, hTERT-HME1, and the poorly invasive breast tumor cell line MCF-7 secreted low levels of ET-1, while the invasive cell lines SKBR3 and MDAMB231 secreted high levels. Expression of the ETs and receptors by the cell lines broadly correlated with their in vitro invasiveness; overexpression of ETs in MCF-7 cells increased basal invasion. ET-mediated invasion involved both receptors and a calcium influx to induce a pertussis toxin-sensitive MAPK pathway. MMP-14 activity was induced via ET-RA in an autocrine manner. In contrast to transformed cells, ET stimulation or overexpression did not induce an invasive phenotype in benign cells. Benign cells do not respond to ETs, and ET expression is not sufficient to induce invasion; however, the level of ET production by tumor cells correlates with their invasiveness, and increasing expression of the ET axis promotes breast tumor cell invasion via both receptors, while MMP-14 is induced via ET-RA."],["dc.identifier.doi","10.1089/dna.2005.24.766"],["dc.identifier.isi","000233319900008"],["dc.identifier.pmid","16274297"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49590"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mary Ann Liebert Inc"],["dc.relation.issn","1044-5498"],["dc.title","Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","52"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Synchrotron Radiation"],["dc.bibliographiccitation.lastpage","63"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Hagemann, Johannes"],["dc.contributor.author","Vaßholz, Malte"],["dc.contributor.author","Hoeppe, Hannes"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Rosselló, Juan M."],["dc.contributor.author","Mettin, Robert"],["dc.contributor.author","Seiboth, Frank"],["dc.contributor.author","Schropp, Andreas"],["dc.contributor.author","Möller, Johannes"],["dc.contributor.author","Hallmann, Jörg"],["dc.contributor.author","Kim, Chan"],["dc.contributor.author","Scholz, Markus"],["dc.contributor.author","Boesenberg, Ulrike"],["dc.contributor.author","Schaffer, Robert"],["dc.contributor.author","Zozulya, Alexey"],["dc.contributor.author","Lu, Wei"],["dc.contributor.author","Shayduk, Roman"],["dc.contributor.author","Madsen, Anders"],["dc.contributor.author","Schroer, Christian G."],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2021-04-14T08:30:07Z"],["dc.date.available","2021-04-14T08:30:07Z"],["dc.date.issued","2021"],["dc.description.abstract","X-ray free-electron lasers (XFELs) have opened up unprecedented opportunities\r\nfor time-resolved nano-scale imaging with X-rays. Near-field propagationbased\r\nimaging, and in particular near-field holography (NFH) in its highresolution\r\nimplementation in cone-beam geometry, can offer full-field views of a\r\nspecimen’s dynamics captured by single XFEL pulses. To exploit this capability,\r\nfor example in optical-pump/X-ray-probe imaging schemes, the stochastic\r\nnature of the self-amplified spontaneous emission pulses, i.e. the dynamics of the\r\nbeam itself, presents a major challenge. In this work, a concept is presented to\r\naddress the fluctuating illumination wavefronts by sampling the configuration\r\nspace of SASE pulses before an actual recording, followed by a principal\r\ncomponent analysis. This scheme is implemented at the MID (Materials Imaging\r\nand Dynamics) instrument of the European XFEL and time-resolved NFH\r\nis performed using aberration-corrected nano-focusing compound refractive\r\nlenses. Specifically, the dynamics of a micro-fluidic water-jet, which is commonly\r\nused as sample delivery system at XFELs, is imaged. The jet exhibits rich\r\ndynamics of droplet formation in the break-up regime. Moreover, pump–probe\r\nimaging is demonstrated using an infrared pulsed laser to induce cavitation and\r\nexplosion of the jet."],["dc.identifier.doi","10.1107/S160057752001557X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83114"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1600-5775"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.rights","CC BY 4.0"],["dc.subject.gro","x-ray imaging"],["dc.title","Single-pulse phase-contrast imaging at free-electron lasers in the hard X-ray regime"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]