Zimmermann, Jasper L.

[["dc.bibliographiccitation.firstpage","74"],["dc.bibliographiccitation.journal","Palaeogeography, Palaeoclimatology, Palaeoecology"],["dc.bibliographiccitation.lastpage","94"],["dc.bibliographiccitation.volume","489"],["dc.contributor.author","Barth, G."],["dc.contributor.author","Franz, M."],["dc.contributor.author","Heunisch, C."],["dc.contributor.author","Ernst, W."],["dc.contributor.author","Zimmermann, J."],["dc.contributor.author","Wolfgramm, M."],["dc.date.accessioned","2020-12-10T15:20:39Z"],["dc.date.available","2020-12-10T15:20:39Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.palaeo.2017.09.029"],["dc.identifier.issn","0031-0182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72750"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Marine and terrestrial sedimentation across the T–J transition in the North German Basin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3067"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Neurophysiology"],["dc.bibliographiccitation.lastpage","3079"],["dc.bibliographiccitation.volume","105"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Zimmermann, Jasper L."],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Funke, Frank"],["dc.contributor.author","Müller, Michael"],["dc.date.accessioned","2018-09-28T10:28:17Z"],["dc.date.available","2018-09-28T10:28:17Z"],["dc.date.issued","2011"],["dc.description.abstract","Rett syndrome (RTT) patients suffer from respiratory arrhythmias with frequent apneas causing intermittent hypoxia. In a RTT mouse model (methyl-CpG-binding protein 2-deficient mice; Mecp2(-/y)) we recently discovered an enhanced hippocampal susceptibility to hypoxia and hypoxia-induced spreading depression (HSD). In the present study we investigated whether this also applies to infant Mecp2(-/y) brain stem, which could become life-threatening due to failure of cardiorespiratory control. HSD most reliably occurred in the nucleus of the solitary tract (NTS) and the spinal trigeminal nucleus (Sp5). HSD susceptibility of the Mecp2(-/y) NTS and Sp5 was increased on 8 mM K(+)-mediated conditioning. 5-HT(1A) receptor stimulation with 8-hydroxy-2-(di-propylamino)tetralin (8-OH-DPAT) postponed HSD by up to 40%, mediating genotype-independent protection. The deleterious impact of HSD on in vitro respiration became obvious in rhythmically active slices, where HSD propagation into the pre-Bötzinger complex (pre-BötC) immediately arrested the respiratory rhythm. Compared with wild-type, the Mecp2(-/y) pre-BötC was invaded less frequently by HSD, but if so, HSD occurred earlier. On reoxygenation, in vitro rhythms reappeared with increased frequency, which was less pronounced in Mecp2(-/y) slices. 8-OH-DPAT increased respiratory frequency but failed to postpone HSD in the pre-BötC. Repetitive hypoxia facilitated posthypoxic recovery only if HSD occurred. In 57% of Mecp2(-/y) slices, however, HSD spared the pre-BötC. Although this occasionally promoted residual hypoxic respiratory activity (\"gasping\"), it also prolonged the posthypoxic recovery, and thus the absence of central inspiratory drive, which in vivo would lengthen respiratory arrest. In view of the breathing disorders in RTTs, the increased hypoxia susceptibility of MeCP2-deficient brain stem potentially contributes to life-threatening disturbances of cardiorespiratory control."],["dc.identifier.doi","10.1152/jn.00822.2010"],["dc.identifier.pmid","21471397"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15858"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1522-1598"],["dc.title","Altered responses of MeCP2-deficient mouse brain stem to severe hypoxia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3053"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Applied Physics Letters"],["dc.bibliographiccitation.lastpage","3055"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Ronning, Carsten"],["dc.contributor.author","Wondratschek, O."],["dc.contributor.author","Buttner, M."],["dc.contributor.author","Hofsass, H."],["dc.contributor.author","Zimmermann, J."],["dc.contributor.author","Leiderer, P."],["dc.contributor.author","Boneberg, J."],["dc.date.accessioned","2018-11-07T11:24:36Z"],["dc.date.available","2018-11-07T11:24:36Z"],["dc.date.issued","2001"],["dc.description.abstract","Boron carbide thin films were grown by mass selected ion beam deposition using low energy B-11(+) and C-12(+) ions at room temperature. The amorphous films exhibit any desired stoichiometry controlled by the ion charge ratio B+/C+. Films with a stoichiometry of B4C showed the optimal combination of a high mechanical strength and a low electrical resistivity for the coating of atomic force microscopy (AFM) silicon cantilevers. The properties of such AFM tips were evaluated and simultaneous topography and Kelvin mode AFM measurements with high lateral resolution were performed on the systems (i) Au nanoparticles on a p-WS2 surface and (ii) conducting/superconducting YBa2Cu3O7-x. (C) 2001 American Institute of Physics."],["dc.identifier.doi","10.1063/1.1415354"],["dc.identifier.isi","000171896600013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56441"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Inst Physics"],["dc.relation.issn","0003-6951"],["dc.title","Superhard, conductive coatings for atomic force microscopy cantilevers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e232"],["dc.bibliographiccitation.journal","Sleep Medicine"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Muntean, M.-L."],["dc.contributor.author","Walther, S."],["dc.contributor.author","Zimmermann, J."],["dc.contributor.author","Sixel-Döring, F."],["dc.contributor.author","Trenkwalder, C."],["dc.date.accessioned","2020-12-10T15:21:18Z"],["dc.date.available","2020-12-10T15:21:18Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.sleep.2017.11.677"],["dc.identifier.issn","1389-9457"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72978"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Polysomnographic findings in restless legs syndrome (RLS) patients with severe augmentation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1423"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Kidney International"],["dc.bibliographiccitation.lastpage","1432"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Schramm, L."],["dc.contributor.author","La, M."],["dc.contributor.author","Heidbreder, E."],["dc.contributor.author","Hecker, M."],["dc.contributor.author","Beckman, J. S."],["dc.contributor.author","Lopau, K."],["dc.contributor.author","Zimmermann, J."],["dc.contributor.author","Rendl, J."],["dc.contributor.author","Reiners, C."],["dc.contributor.author","Winderl, S."],["dc.contributor.author","Wanner, C."],["dc.contributor.author","Schmidt, HHHW"],["dc.date.accessioned","2018-11-07T10:30:57Z"],["dc.date.available","2018-11-07T10:30:57Z"],["dc.date.issued","2002"],["dc.description.abstract","Background. The \"L-arginine paradox\" refers to situations where L-arginine (L-Arg) supplementation stimulates nitric oxide (NO) synthesis, despite saturating intracellular concentrations. This paradox is frequently observed in acute renal failure (ARF). First, the effects of L-Arg on renal function of rats with ARF were studied. Based on the promising results from these initial studies, the second part of our study searched for a form of ARF in humans that could be studied easily under conditions with little variance and yet was linked with endothelial dysfunction. Thus, we investigated the effects of L-Arg supplementation immediately after kidney transplantation in 54 patients. Methods. In uranyl nitrate-induced ARF in rats the effects of L-Arg and L-NNA (inhibitor of nitric oxide synthase; NOS) on glomerular filtration rate (GFR), renal plasma flow (RPF), blood pressure (BP) and NOx (NO2- + NO3-) excretion were examined. Tissue L-Arg levels, NOS activities, immunodetection of NOS and superoxide dismutase (SOD), activities of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and xanthine oxidase, and nitrotyrosine immunoreactive protein (NT-IR) were determined and compared to sham operated animals. Secondly, in a randomized, double-blind study, the effects of L-Arg on GFR and RPF were investigated in 54 kidney transplant recipients, receiving IV L-Arg for three days. GFR and RPF were measured on days 1, 3, 5 and 10 by scintigraphy. Results. In experimental ARF, decreased RPF and GFR were associated with reduced tissue L-Arg levels, endothelial NOS-III expression, NO formation and NOx excretion. Reduction in GFR, RPF and NO, excretion were reversed upon administration of exogenous L-Arg. There also was a loss of Cu,Zn-SOD, a key enzyme against oxidative stress, and an elevation of NT-IR, an indicator of nitrosative stress and suggested marker for pathological actions of NO. However, NT-IR was not dependent on de novo NO synthesis and not related to the functional effects of L-Arg administration. In kidney transplant recipients receiving organs with a short cold ischemia time (CIT) and from young donors, that is, those with a higher likelihood of a functional endothelium, early administration of L-Arg improved renal function. Conclusion. Both experimental and clinical data show that L-Arg deficiency and endothelial dysfunction are pathomechanistically relevant in ARE The data suggest a therapeutic potential for the administration of L-Arg in ARF and kidney transplantation, at least in patients receiving kidneys with shorter CIT and from younger donors."],["dc.identifier.doi","10.1046/j.1523-1755.2002.00268.x"],["dc.identifier.isi","000174465100024"],["dc.identifier.pmid","11918749"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43984"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Inc"],["dc.relation.issn","0085-2538"],["dc.title","L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1440"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.lastpage","1448"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Zimmermann, J."],["dc.contributor.author","Wolter, A."],["dc.contributor.author","Krischke, N. R."],["dc.contributor.author","Preuss, Ulrich W."],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T08:50:22Z"],["dc.date.available","2018-11-07T08:50:22Z"],["dc.date.issued","2011"],["dc.description.abstract","This naturalistic study investigates in detail symptom reduction during acute inpatient treatment (response), long-term symptom improvement in the post-acute phase (remission) and the rate of re-hospitalisations. A total of 183 patients were enrolled. Criteria for response were PANSS total score and syndrome reductions of 20, 30, 40 and 50%. Remission criteria employed were based on recommendations from Andreasen et al. The average length of stay was 45.6 days (SD 42.7). PANSS total score response rates were found to be 63.9% for the 20% level and were reduced in the following consecutive levels by approximately 15%. Only 10.3% of the patients remitted during a 1-year follow-up period. At least one re-hospitalisation was reported for 43.9% of the subjects. Compared to previous randomised and controlled trials, the rates of response and remission are significantly lower. In daily inpatient care, the chronic course of schizophrenia is far commoner than expected from previous reports."],["dc.identifier.doi","10.1007/s00115-010-3202-6"],["dc.identifier.isi","000296644100009"],["dc.identifier.pmid","21221520"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21684"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0028-2804"],["dc.title","Response and remission in schizophrenic subjects"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.contributor.author","Nitsch, L."],["dc.contributor.author","Kaps, V."],["dc.contributor.author","Zschernack, V."],["dc.contributor.author","Gancarczyk, N."],["dc.contributor.author","van Essen, F."],["dc.contributor.author","Schmeel, C."],["dc.contributor.author","Klockgether, T."],["dc.contributor.author","Zimmermann, J."],["dc.contributor.author","Müller, M."],["dc.date.accessioned","2021-12-01T09:23:24Z"],["dc.date.available","2021-12-01T09:23:24Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s00115-021-01194-x"],["dc.identifier.pii","1194"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94642"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","1433-0407"],["dc.relation.issn","0028-2804"],["dc.title","Immuncheckpointinhibitoren in der Behandlung der progressiven multifokalen Leukenzephalopathie"],["dc.title.translated","Immune checkpoint inhibitors in the treatment of progressive multifocal leukoencephalopathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]