Kuhn, Hans-Jürg

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cell and Tissue Research"],["dc.bibliographiccitation.lastpage","13"],["dc.bibliographiccitation.volume","316"],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Washausen, Stefan"],["dc.contributor.author","Brunnett, G."],["dc.contributor.author","Kuhn, H. J."],["dc.date.accessioned","2018-11-07T10:49:47Z"],["dc.date.available","2018-11-07T10:49:47Z"],["dc.date.issued","2004"],["dc.description.abstract","Whether rhombomere-specific patterns of apoptosis exist in the developing hindbrain of vertebrates is under debate. We have investigated the sequence of apoptotic events in three-dimensionally reconstructed hindbrains of Tupaia belangeri (8- to 19-somite embryos). Apoptotic cells were identified by structural criteria and by applying an in situ tailing technique to visualize DNA fragmentation. Seven rhombomeres originated from three pro-rhombomeres. Among pre-migratory neural crest cells in the dorsal thirds of the neural folds, the earliest apoptotic concentrations appeared in the developing third rhombomere (r3). Dorsal apoptotic maxima then persisted in r3, extended from r3 to r2, and also arose in r5. Transverse apoptotic bands increased the total amount of apoptotic cells in odd-numbered rhombomeres first in r3 and, with a delay, also in r5. This sequence of apoptotic events was paralleled by an approximate rostrocaudal sequence of neural crest cell delamination from the even-numbered rhombomeres. Thus, large-scale apoptosis in r3 and r5 helped to establish crest-free zones that segregated streams of migrating neural crest cells adjacent to r2, r4, and r6. The sequence of apoptotic events observed in the dorsal thirds of rhombomeres matches that reported for the chick embryo. Other shared features are apoptotic peaks in the position of a circumscribed ventricular protrusion of fusing parts of the neural folds in r1 and r2, and Y-shaped apoptotic patterns composed of apoptotic maxima in the dorsal and lateral thirds of r1, r2, and r3. These rhombomere-specific patterns of apoptosis may therefore represent a conserved character, at least in amniotes."],["dc.identifier.doi","10.1007/s00441-004-0855-0"],["dc.identifier.isi","000220298800001"],["dc.identifier.pmid","14986099"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48509"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0302-766X"],["dc.title","Rhombomere-specific patterns of apoptosis in the tree shrew Tupaia belangeri"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","428"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Journal of Comparative Neurology"],["dc.bibliographiccitation.lastpage","436"],["dc.bibliographiccitation.volume","420"],["dc.contributor.author","Malz, Cordula R."],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Kuhn, H. J."],["dc.date.accessioned","2018-11-07T10:51:01Z"],["dc.date.available","2018-11-07T10:51:01Z"],["dc.date.issued","2000"],["dc.description.abstract","The distribution of the calcium-binding protein calretinin was studied in peripheral and central parts of the main olfactory system (MOS) and the vomeronasal system (VNS) of adult tree shrew Tupaia belangeri. The calretinin immunoreaction was carried out with a peroxidase-coupled polyclonal antibody. In the VNS, complete labeling of all receptor cells and vomeronasal nerve fibers was observed, whereas only a subset of the somata and dendrites of receptor cells and of the olfactory nerve fibers of the MOS was immunoreactive. From the immunoreactive dendritic clubs of vomeronasal receptor cells, calretinin-labeled structures, presumably clumps of microvilli, arose that terminated within immunopositive portions of the mucus. In the main olfactory bulb, the neuropil of some of the glomeruli was immunoreactive. All periglomerular and many mitral. cells were labeled. The external plexiform layer was subdivided into a faintly immunoreactive superficial half and a strongly immunoreactive deep half. Immunoreactive basal dendrites of mitral cells could be followed into either the deep half or the superficial half. In the laminated internal granular layer, a subset of immunopositive granule cells extended dendrites into the external plexiform layer. Mitral cells and granule cells with dendrites ascending to different levels of the external plexiform layer may represent functional subclasses. In the accessory olfactory bulb, all vomeronasal nerve fibers, glomeruli, and mitral/tufted cells were labeled, whereas immunoreactive periglomerular cells and internal granule cells were only scattered. In Tupaia, calretinin immunoreactivity is a more general property of the primary projecting neurons of the VNS than of the MOS and possibly indicates the involvement of calretinin in the perception of certain of the olfactory qualities. (C) 2000 Wiley-Liss,Inc."],["dc.identifier.doi","10.1002/(SICI)1096-9861(20000515)420:4<428::AID-CNE2>3.0.CO;2-2"],["dc.identifier.isi","000086745000002"],["dc.identifier.pmid","10805918"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48788"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0021-9967"],["dc.title","Pattern of calretinin immunoreactivity in the main olfactory system and the vomeronasal system of the tree shrew, Tupaia belangeri"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0165-3806(02)00299-7"],["dc.bibliographiccitation.firstpage","39"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","DEVELOPMENTAL BRAIN RESEARCH"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","135"],["dc.contributor.author","Malz, Cordula R."],["dc.contributor.author","Kuhn, H. M."],["dc.date.accessioned","2018-11-07T10:30:31Z"],["dc.date.available","2018-11-07T10:30:31Z"],["dc.date.issued","2002"],["dc.description.abstract","The distribution and development of FMRFamide- and calretinin-immunoreactive neurons were investigated in the nervus terminalis of prenatal tree shrews from gestation day 19 onwards. The first FMRFamide-immunoreactive cells were observed medially in the olfactory epithelium on gestation day 20. From gestation day 23 onwards, the migrating nervus terminalis ganglion cells showed FMRFamide calretinin immunoreactivity. The distribution pattern of FMRFamide- and calretinin-immunoreactive cells was similar along the migratory route and in the ganglion of the terminal nerve. However, most probably calretinin and FMRFamide were expressed in separate neuronal populations. For the first time in a mammal, FMRFamide and calretinin are reported to occur in the migrating perikarya and neuronal processes of the nervus terminalis during prenatal development. The results suggest (i) an early activation of the rostral FMRFamide-immunoreactive migratory stream comparable to that described for the GnRH-immunoreactive part of the terminal nerve in other mammals and possibly (ii) an involvement of calretinin in mechanisms of cell migration and outgrowth of neuronal processes in the terminal nerve during the studied period. (C) 2002 Elsevier Science B.V. All rights reserved."],["dc.identifier.doi","10.1016/S0165-3806(02)00299-7"],["dc.identifier.isi","000175580700005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43891"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0165-3806"],["dc.title","Calretinin and FMRFarmide immunoreactivity in the nervus terminalis of prenatal tree shrews (Tupaia belangeri)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","83"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","ANATOMY AND EMBRYOLOGY"],["dc.bibliographiccitation.lastpage","97"],["dc.bibliographiccitation.volume","205"],["dc.contributor.author","Malz, Cordula R."],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Kuhn, H. J."],["dc.date.accessioned","2018-11-07T10:29:56Z"],["dc.date.available","2018-11-07T10:29:56Z"],["dc.date.issued","2002"],["dc.description.abstract","The prenatal patterns of calretinin immunoreactivity were studied in the olfactory systems of Tupaia belangeri. We investigated the peripheral and primary central parts of the vomeronasal system and of the main olfactory system from the 19th to the 43rd (last) day of gestation and compared the findings with the known calretinin immunoreactivity patterns in adult T belangeri and the published data on other mammals. The onset of calretinin immunoreactivity was noted in the main olfactory system on the 23rd day of gestation and, in the vomeronasal system, on the 25th day of gestation: single precursors of receptor cells with calretinin immunoreactive perikarya and processes were observed in both epithelia. Their neuronal identity was proven by olfactory marker protein immunoreactivity. On the 42nd day of gestation, almost all receptor cells and nerve fibers, many interneurons and projecting cells were calretinin immunoreactive in the main olfactory and in the vomeronasal systems. In contrast to the intensive calretinin labeling previously observed in virtually all vomeronasal epithelial cells of adult T belangeri, among developing receptor cells a population of intensively labeled, basally located perikarya was distinguishable from a population of less intensively stained, more apically located ones. In the main olfactory epithelium of fetal T belangeri, calretinin immunoreactive receptor cells occurred in the middle layers. Whereas in the vomeronasal sensory epithelium differently reacting layers of receptor cells might represent the two known subfamilies of receptor cells, in the main olfactory epithelium the differing calretinin expression in the layers of the epithelium, most probably, did not reflect known subfamilies of odour receptor cells. Transiently, ectopic calretinin immunoreactive receptor cells were observed in the future non-sensory epithelium of the vomeronasal organ."],["dc.identifier.doi","10.1007/s00429-002-0244-y"],["dc.identifier.isi","000176029800002"],["dc.identifier.pmid","12021911"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43754"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-2061"],["dc.title","Calretinin immunoreactivity in the prenatally developing olfactory systems of the tree shrew Tupaia belangeri"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0165-0270(02)00247-9"],["dc.bibliographiccitation.firstpage","169"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.lastpage","180"],["dc.bibliographiccitation.volume","121"],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Washausen, Stefan"],["dc.contributor.author","Brunnett, G."],["dc.contributor.author","Kuhn, H. R."],["dc.date.accessioned","2018-11-07T09:42:12Z"],["dc.date.available","2018-11-07T09:42:12Z"],["dc.date.issued","2002"],["dc.description.abstract","The present study demonstrates how, predominantly by external fiducials, histological serial sections used to reconstruct patterns of individually marked cellular events in large organs or whole embryos can be realigned with the help of 'reference series'. Resin-embedded embryos were cut at 1 mum and consecutive sections were alternately placed on two sets of slides. For cytological diagnosis and acquisition of embryonic contours, stained sections of the first series, termed 'working series', were scanned with the x 100 objective using 'Huge Image', a recently established image acquisition system. For acquisition of the contours of the resin block, adjacent unstained sections of the second series, termed 'reference series', were scanned with the x 5 objective. Thereafter, 'hybrid sections' were created which combined vectorized embryonic contours and cellular events taken from the working series with vectorized block contours taken from the reference series. For realignment, consecutive 'hybrid sections' were matched by best-fit of the block contours. Stacks of realigned 'hybrid sections' were shaped like truncated pyramids and, thus, reflected repeated 'trimming' of the resin block during the sectioning procedure. Among 266 'hybrid sections' at intervals of 8 gm, needed to reconstruct the brain of a 15-day-old embryo of Tupaia belangeri (Scandentia), internal fiducials were required five times for realigning a total of six adjacent truncated pyramids. Application of this method provided realistic reconstructions of the positions of apoptotic cells in the entire developing brain without the need of secondary introduction of external fiducials. (C) 2002 Elsevier Science B.V. All rights reserved."],["dc.identifier.doi","10.1016/S0165-0270(02)00247-9"],["dc.identifier.isi","000179968900006"],["dc.identifier.pmid","12468007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33903"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0165-0270"],["dc.title","Use of 'reference series' to realign histological serial sections for three-dimensional reconstructions of the positions of cellular events in the developing brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","141"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Zoology"],["dc.bibliographiccitation.lastpage","156"],["dc.bibliographiccitation.volume","214"],["dc.contributor.author","Zeller, U."],["dc.contributor.author","Epple, G."],["dc.contributor.author","Küderling, I."],["dc.contributor.author","Kuhn, H.‐J."],["dc.date.accessioned","2022-10-06T13:25:11Z"],["dc.date.available","2022-10-06T13:25:11Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1111/j.1469-7998.1988.tb04992.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114775"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1469-7998"],["dc.relation.issn","0952-8369"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","The anatomy of the circumgenital scent gland of Saguinus fuscicollis (Callitrichidae, Primates)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","919"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Planta"],["dc.bibliographiccitation.lastpage","930"],["dc.bibliographiccitation.volume","220"],["dc.contributor.author","Gerhardt, B."],["dc.contributor.author","Fischer, K."],["dc.contributor.author","Balkenhohl, T. J."],["dc.contributor.author","Pohnert, G."],["dc.contributor.author","Kuhn, H."],["dc.contributor.author","Wasternack, Claus"],["dc.contributor.author","Feussner, Ivo"],["dc.date.accessioned","2018-11-07T11:13:51Z"],["dc.date.available","2018-11-07T11:13:51Z"],["dc.date.issued","2005"],["dc.description.abstract","During the early stages of germination, a lipid-body lipoxygenase is expressed in the cotyledons of sunflowers (Helianthus annuus L.). In order to obtain evidence for the in vivo activity of this enzyme during germination. we analyzed the lipoxygenase-dependent metabolism of polyunsaturated fatty acids esterified in the storage lipids. For this purpose, lipid bodies were isolated from etiolated sunflower cotyledons at different stages of germination, and the storage triacylglycerols were analyzed for oxygenated derivatives. During the time course of germination the amount of oxygenated storage lipids was strongly augmented. and we detected triacylglycerols containing one. two or three residues of (9Z, 11E, 13S)- 13-hydro(pero)xy-octadeca-9,11-dienoic acid. Glyoxysomes from etiolated sunflower cotyledons converted (9Z, I I E, 13S)-13-hydroxy-octadeca-9,11-dienoic acid to (9Z, 11E)-13-oxo-octadeca-9,11-dienoic acid via an NADH-dependent dehydrogenase reaction. Both oxygenated fatty acid derivatives were activated to the corresponding CoA esters and subsequently metabolized to compounds of shorter chain length. Cofactor requirement and formation of acetyl-CoA indicate degradation via β-oxidation. However, β-oxidation only proceeded for two consecutive cycles, leading to accumulation of a medium-chain metabolite carrying an oxo group at C-9, equivalent to C-13 of the parent (9Z,11E,13S)-13-hydroxy-octadeca-9,11-dienoic acid. Short-chain β-oxidation intermediates were not detected during incubation. Similar results were obtained when 13-hydroxy octadecanoic acid was used as β-oxidation substrate. On the other hand, the degradation of (9Z, 11E)-octadeca-9,11-dienoic acid was accompanied by the appearance of short-chain β-oxidation intermediates in the reaction mixture. The results suggest that the hydroxyl/oxo group at C-13 of lipoxygenase-derived fatty acids forms a barrier to continuous β-oxidation by glyoxysomes."],["dc.identifier.doi","10.1007/s00425-004-1408-1"],["dc.identifier.isi","000229185800012"],["dc.identifier.pmid","15526214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53993"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0032-0935"],["dc.title","Lipoxygenase-mediated metabolism of storage lipids in germinating sunflower cotyledons and beta-oxidation of (9Z,11E,13S)-13-hydroxy-octadeca-9,11-dienoic acid by the cotyledonary glyoxysomes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0034-4885(02)15613-2"],["dc.bibliographiccitation.firstpage","651"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Reports on Progress in Physics"],["dc.bibliographiccitation.lastpage","788"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Jooss, C."],["dc.contributor.author","Albrecht, J."],["dc.contributor.author","Kuhn, H."],["dc.contributor.author","Leonhardt, S."],["dc.contributor.author","Kronmuller, H."],["dc.date.accessioned","2018-11-07T10:30:27Z"],["dc.date.available","2018-11-07T10:30:27Z"],["dc.date.issued","2002"],["dc.description.abstract","In the past few years magneto-optical flux imaging (MOI) has come to take an increasing role in the investigation and understanding of critical current densities in high-T-c superconductors (HTS). This has been related to the significant progress in quantitative high-resolution magneto-optical imaging of flux distributions together with the model-independent determination of the corresponding current distributions. We review in this article the magneto-optical imaging technique and experiments on thin films, single crystals, polycrystalline bulk ceramics, tapes and melt-textured HTS materials and analyse systematically the properties determining the spatial distribution and the magnitude of the supercurrents. First of all, the current distribution is determined by the sample geometry. Due to the boundary conditions at the sample borders, the current distribution in samples of arbitrary shape splits up into domains of nearly uniform parallel current flow which are separated by current domain boundaries, where the current streamlines are sharply bent. Qualitatively, the current pattern is described by the Bean model; however, changes due to a spatially dependent electric field distribution which is induced by flux creep or flux flow have to be taken into account. For small magnetic fields, the Meissner phase coexists with pinned vortex phases and the geometry-dependent Meissner screening currents contribute to the observed current patterns. The influence of additional factors on the current domain patterns are systematically analysed: local magnetic field dependence of j(c)(B), current anisotropy, inhomogeneities and local transport properties of grain boundaries. We then continue to an overview of the current distribution and current-limiting factors of materials, relevant to technical applications like melt-textured samples, coated conductors and tapes. Finally, a selection of magneto-optical experiments which give direct insight into vortex pinning and depinning mechanisms are reviewed."],["dc.identifier.doi","10.1088/0034-4885/65/5/202"],["dc.identifier.isi","000175846100002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43872"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.issn","1361-6633"],["dc.relation.issn","0034-4885"],["dc.title","Magneto-optical studies of current distributions in high-T-c superconductors"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","49"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Brain Structure and Function"],["dc.bibliographiccitation.lastpage","65"],["dc.bibliographiccitation.volume","214"],["dc.contributor.author","Knabe, Wolfgang"],["dc.contributor.author","Obermayer, Bastian"],["dc.contributor.author","Kuhn, Hans-Juerg"],["dc.contributor.author","Brunnett, Guido"],["dc.contributor.author","Washausen, Stefan"],["dc.date.accessioned","2018-11-07T11:21:18Z"],["dc.date.available","2018-11-07T11:21:18Z"],["dc.date.issued","2009"],["dc.description.abstract","The neurogenic trigeminal placode develops from the crescent-shaped panplacodal primordium which delineates the neural plate anteriorly. We show that, in Tupaia belangeri, the trigeminal placode is represented by a field of focal ectodermal thickenings which over time changes positions from as far rostral as the level of the forebrain to as far caudal as opposite rhombomere 3. Delamination proceeds rostrocaudally from the ectoderm adjacent to the rostral midbrain, and contributes neurons to the trigeminal ganglion as well as to the ciliary ganglion/oculomotor complex. Proliferative events are centered on the field prior to the peak of delamination. They are preceded, paralleled and, finally, outnumbered by apoptotic events which proceed rostrocaudally from non-delaminating to delaminating parts of the field. Apoptosis persists upon regression of the placode, thereby exhibiting a massive \"wedge\" of apoptotic cells which includes the postulated position of the \"ventrolateral postoptic placode\" (Lee et al. in Dev Biol 263:176-190, 2003), merges with groups of lens-associated apoptotic cells, and disappears upon lens detachment. In conjunction with earlier work (Washausen et al. in Dev Biol 278:86-102, 2005) our findings suggest that apoptosis contributes repeatedly to the disintegration of the panplacodal primordium, to the elimination of subsets of premigratory placodal neuroblasts, and to the regression of placodes."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [KN 525/1-1, KN 525/1-2, BR 1185/4-1]"],["dc.identifier.doi","10.1007/s00429-009-0228-2"],["dc.identifier.isi","000272158400005"],["dc.identifier.pmid","19915864"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4151"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55743"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1863-2653"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Apoptosis and proliferation in the trigeminal placode"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","278"],["dc.contributor.author","Washausen, Stefan"],["dc.contributor.author","Obermayer, Bastian"],["dc.contributor.author","Brunnett, Guido"],["dc.contributor.author","Kuhn, Hans-Jürg"],["dc.contributor.author","Knabe, Wolfgang"],["dc.date.accessioned","2018-11-07T11:25:44Z"],["dc.date.available","2018-11-07T11:25:44Z"],["dc.date.issued","2005"],["dc.description.abstract","Epibranchial placodes and rhombencephalic neural crest provide precursor cells for the geniculate, petrosal, and nodose ganglia., In chick embryos and in Tupaia belangeri, apoptosis, in rhombomeres 3 and 5 helps to select premigratory precursor cells and to segregate crest cell streams derived from the even-numbered rhombomeres. Much less is known about the patterns and functions of apoptosis in epibranchial placodes. We found that, in Tupaia belangeri, combined anlagen of the otic placode and epibranchial placode 1 transiently share a primordial low grade thickening with post-otic epibranchial placodes. Three-dimensional reconstructions reveal complementary, spatially, and temporally regulated apoptotic and proliferative events that demarcate the otic placode and epibranchial placode 1, and help to individualize three pairs of epibranchial placodes in a rostrocaudal sequence. Later, rostrocaudal waves of proliferation and apoptosis extend from dorsal to ventral parts of the placodes, paralleled by the dorsoventral progression of precursor cell delamination. These findings suggest a role for apoptosis during the process of neuroblast generation in the epibranchial placodes. Finally, apoptosis eliminates remnants of the placodes in the presence of late invading macrophages. (C) 2004 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2004.10.016"],["dc.identifier.isi","000226680400008"],["dc.identifier.pmid","15649463"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56692"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0012-1606"],["dc.title","Apoptosis and proliferation in developing, mature, and regressing epibranchial placodes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]