Zippelius, Annette

[["dc.bibliographiccitation.firstpage","14001"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","EPL"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Mokhtari, Zahra"],["dc.contributor.author","Aspelmeier, Timo"],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2020-12-10T18:41:38Z"],["dc.date.available","2020-12-10T18:41:38Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1209/0295-5075/120/14001"],["dc.identifier.eissn","1286-4854"],["dc.identifier.issn","0295-5075"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77635"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Collective rotations of active particles interacting with obstacles"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","214905"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","The Journal of Chemical Physics"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Wald, Christian"],["dc.contributor.author","Goldbart, Paul M."],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2018-11-07T09:41:48Z"],["dc.date.available","2018-11-07T09:41:48Z"],["dc.date.issued","2006"],["dc.description.abstract","We consider a microscopic model of a polymer blend that is prone to phase separation. Permanent cross-links are introduced between randomly chosen pairs of monomers, drawn from the Deam-Edwards distribution. Thereby, not only density but also concentration fluctuations of the melt are quenched-in in the gel state, which emerge upon sufficient cross-linking. We derive a Landau expansion in terms of the order parameters for gelation and phase separation, and analyze it on the mean-field level, including Gaussian fluctuations. The mixed gel is characterized by thermal as well as time-persistent (glassy) concentration fluctuations. Whereas the former are independent of the preparation state, the latter reflect the concentration fluctuations at the instant of cross-linking, provided the mesh size is smaller than the correlation length of phase separation. The mixed get becomes unstable to microphase separation upon lowering the temperature in the gel phase. Whereas the length scale of microphase separation is given by the mesh size, at least close to the transition, the emergent microstructure depends on the composition and compressibility of the melt. Hexagonal structures, as well as lamellas or random structures with a unique wavelength, can be energetically favorable. (c) 2006 American Institute of Physics."],["dc.identifier.doi","10.1063/1.2200697"],["dc.identifier.isi","000238758700049"],["dc.identifier.pmid","16774440"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33812"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Inst Physics"],["dc.relation.issn","1089-7690"],["dc.relation.issn","0021-9606"],["dc.title","Glassy correlations and microstructures in randomly cross-linked homopolymer blends"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","051802"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Physical Review. E"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Xing, Xiangjun"],["dc.contributor.author","Pfahl, Stephan"],["dc.contributor.author","Mukhopadhyay, Swagatam"],["dc.contributor.author","Goldbart, Paul M."],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2018-11-07T11:15:48Z"],["dc.date.available","2018-11-07T11:15:48Z"],["dc.date.issued","2008"],["dc.description.abstract","A Landau theory is constructed for the gelation transition in cross-linked polymer systems possessing spontaneous nematic ordering, based on symmetry principles and the concept of an order parameter for the amorphous solid state. This theory is substantiated with help of a simple microscopic model of cross-linked dimers. Minimization of the Landau free energy in the presence of nematic order yields the neoclassical theory of the elasticity of nematic elastomers and, in the isotropic limit, the classical theory of isotropic elasticity. These phenomenological theories of elasticity are thereby derived from a microscopic model, and it is furthermore demonstrated that they are universal mean-field descriptions of the elasticity for all chemical gels and vulcanized media."],["dc.identifier.doi","10.1103/PhysRevE.77.051802"],["dc.identifier.isi","000256885400084"],["dc.identifier.pmid","18643092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54445"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","1539-3755"],["dc.title","Nematic elastomers: From a microscopic model to macroscopic elasticity theory"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3161"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Macromolecules"],["dc.bibliographiccitation.lastpage","3164"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","von der Heydt, Alice"],["dc.contributor.author","Mueller, Marcus"],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2018-11-07T08:44:08Z"],["dc.date.available","2018-11-07T08:44:08Z"],["dc.date.issued","2010"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SFB-602/B6]"],["dc.identifier.doi","10.1021/ma100192n"],["dc.identifier.isi","000276232800010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20130"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0024-9297"],["dc.title","Sequence Fractionation in Symmetric Random Block Copolymers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5360"],["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.lastpage","5363"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","Broderix, K."],["dc.contributor.author","Bhattacharya, K. K."],["dc.contributor.author","Cavagna, A."],["dc.contributor.author","Zippelius, Annette"],["dc.contributor.author","Giardina, I."],["dc.date.accessioned","2018-11-07T09:17:56Z"],["dc.date.available","2018-11-07T09:17:56Z"],["dc.date.issued","2000"],["dc.description.abstract","Molecular dynamics simulations are used to generate an ensemble of saddles of the potential energy of a Lennard-Jones liquid. Classifying all extrema by their potential energy u and number of unstable directions k, a well-defined relation k(u) is revealed. The degree of instability of typical stationary points vanishes at a threshold potential energy u(th), which lies above the energy of the lowest glassy minima of the system. The energies of the inherent states, as obtained by the Stillinger-Weber method, approach u(th) at a temperature close to the mode-coupling transition temperature T-c."],["dc.identifier.doi","10.1103/PhysRevLett.85.5360"],["dc.identifier.isi","000165884200025"],["dc.identifier.pmid","11135996"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28291"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","American Physical Soc"],["dc.relation.issn","0031-9007"],["dc.title","Energy landscape of a Lennard-Jones liquid: Statistics of stationary points"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","032701"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Physical Review. E"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","von der Heydt, Alice"],["dc.contributor.author","Wilkin, Daniel"],["dc.contributor.author","Benetatos, Panayotis"],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2018-11-07T09:20:01Z"],["dc.date.available","2018-11-07T09:20:01Z"],["dc.date.issued","2013"],["dc.description.abstract","Aiming at the mechanical properties of cross-linked biopolymers, we set up and analyze a model of two weakly bending wormlike chains subjected to a tensile force, with regularly spaced inter-chain bonds (cross-links) represented by harmonic springs. Within this model, we compute the force-extension curve and the differential stiffness exactly and discuss several limiting cases. Cross-links effectively stiffen the chain pair by reducing thermal fluctuations transverse to the force and alignment direction. The extra alignment due to cross-links increases both with growing number and with growing strength of the cross-links, and is most prominent for small force f. For large f, the additional, cross-link-induced extension is subdominant except for the case of linking the chains rigidly and continuously along their contour. In this combined limit, we recover asymptotically the elasticity of a weakly bending wormlike chain without constraints, stiffened by a factor of 4. The increase in differential stiffness can be as large as 100% for small f or large numbers of cross-links."],["dc.identifier.doi","10.1103/PhysRevE.88.032701"],["dc.identifier.fs","599508"],["dc.identifier.isi","000323895200005"],["dc.identifier.pmid","24125288"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10511"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28777"],["dc.notes","Financial support by the DFG Grants No. SFB-937/A1 and No. SFB-937/A4"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","2470-0053"],["dc.relation.issn","2470-0045"],["dc.relation.orgunit","Fakultät für Physik"],["dc.title","Elasticity of cross-linked semiflexible biopolymers under tension"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","64"],["dc.bibliographiccitation.journal","BMC Neuroscience"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Jaiswal, Manoj Kumar"],["dc.contributor.author","Zech, Wolf-Dieter"],["dc.contributor.author","Goos, Miriam"],["dc.contributor.author","Leutbecher, Christine"],["dc.contributor.author","Ferri, Alberto"],["dc.contributor.author","Zippelius, Annette"],["dc.contributor.author","Carri, Maria Teresa"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Keller, Bernhard U."],["dc.date.accessioned","2018-11-07T08:28:40Z"],["dc.date.available","2018-11-07T08:28:40Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but the underlying mechanisms are not well understood. The present evidence supports a hypothesis that mitochondria are a target of mutant SOD1-mediated toxicity in familial amyotrophic lateral sclerosis (fALS) and intracellular alterations of cytosolic and mitochondrial calcium might aggravate the course of this neurodegenerative disease. In this study, we used a fluorescence charged cool device (CCD) imaging system to separate and simultaneously monitor cytosolic and mitochondrial calcium concentrations in individual cells in an established cellular model of ALS. Results: To gain insights into the molecular mechanisms of SOD1(G93A) associated motor neuron disease, we simultaneously monitored cytosolic and mitochondrial calcium concentrations in individual cells. Voltage - dependent cytosolic Ca(2+) elevations and mitochondria - controlled calcium release mechanisms were monitored after loading cells with fluorescent dyes fura-2 and rhod-2. Interestingly, comparable voltage-dependent cytosolic Ca(2+) elevations in WT (SH-SY5Y(WT)) and G93A (SH-SY5Y(G93A)) expressing cells were observed. In contrast, mitochondrial intracellular Ca(2+) release responses evoked by bath application of the mitochondrial toxin FCCP were significantly smaller in G93A expressing cells, suggesting impaired calcium stores. Pharmacological experiments further supported the concept that the presence of G93A severely disrupts mitochondrial Ca(2+) regulation. Conclusion: In this study, by fluorescence measurement of cytosolic calcium and using simultaneous [Ca(2+)]i and [Ca(2+)](mito) measurements, we are able to separate and simultaneously monitor cytosolic and mitochondrial calcium concentrations in individual cells an established cellular model of ALS. The primary goals of this paper are (1) method development, and (2) screening for deficits in mutant cells on the single cell level. On the technological level, our method promises to serve as a valuable tool to identify mitochondrial and Ca(2+)-related defects during G93A-mediated MN degeneration. In addition, our experiments support a model where a specialized interplay between cytosolic calcium profiles and mitochondrial mechanisms contribute to the selective degeneration of neurons in ALS."],["dc.identifier.doi","10.1186/1471-2202-10-64"],["dc.identifier.isi","000268695200001"],["dc.identifier.pmid","19545440"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5754"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16476"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","1471-2202"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","68003"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","EPL"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Vogel, Florian"],["dc.contributor.author","Zippelius, Annette"],["dc.contributor.author","Fuchs, Matthias"],["dc.date.accessioned","2020-12-10T18:41:38Z"],["dc.date.available","2020-12-10T18:41:38Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1209/0295-5075/125/68003"],["dc.identifier.eissn","1286-4854"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77637"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Emergence of Goldstone excitations in stress correlations of glass-forming colloidal dispersions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","65"],["dc.bibliographiccitation.journal","Neurocomputing"],["dc.bibliographiccitation.lastpage","71"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Trommershauser, J."],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2018-11-07T09:01:49Z"],["dc.date.available","2018-11-07T09:01:49Z"],["dc.date.issued","2001"],["dc.description.abstract","A stochastic model of synaptic transmission has been designed on the basis of electrophysiological experiments. The model includes presynaptic mechanisms of recruitment and calcium related release of vesicles, transmitter dynamics in the cleft and postsynaptic receptor kinetics. Monte Carlo simulations of a single synaptic connection are performed and demonstrate that synapses depress during repetitive presynaptic stimulation due to depletion of presynaptic vesicles as well as receptor desensitization. Only for stimulation frequencies below 40 Hz depression is caused solely presynaptically by depletion of vesicles. It is shown that specific physiological conditions determine the frequency dependence of steady state depression currents and set limits on the range of possibly rate-coded transmission. (C) 2001 Elsevier Science B.V. All rights reserved."],["dc.identifier.doi","10.1016/S0925-2312(01)00486-6"],["dc.identifier.isi","000169129200010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24523"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","9th Annual Computational Neuroscience Meeting (CNS*00)"],["dc.relation.eventlocation","BRUGGE, BELGIUM"],["dc.relation.issn","0925-2312"],["dc.title","Biophysical model of a single synaptic connection: Transmission properties are determined by the cooperation of pre- and postsynaptic mechanisms"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","198301"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Benetatos, Panayotis"],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2018-11-07T10:54:12Z"],["dc.date.available","2018-11-07T10:54:12Z"],["dc.date.issued","2007"],["dc.description.abstract","Motivated by the organization of cross-linked cytoskeletal biopolymers, we present a semimicroscopic replica field theory for the formation of anisotropic random networks of semiflexible polymers. The networks are formed by introducing random permanent cross-links which fix the orientations of the corresponding polymer segments to align with one another. Upon increasing the cross-link density, we obtain a continuous gelation transition from a fluid phase to a gel where a finite fraction of the system gets localized at random positions. For sufficiently stiff polymers, this positional localization is accompanied by a continuous isotropic-to-nematic (IN) transition occurring at the same cross-link density. As the polymer stiffness decreases, the IN transition becomes first order, shifts to a higher cross-link density, and is preceded by an amorphous solid where the average polymer orientations freeze in random directions."],["dc.identifier.doi","10.1103/PhysRevLett.99.198301"],["dc.identifier.isi","000250810500074"],["dc.identifier.pmid","18233121"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49514"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","0031-9007"],["dc.title","Anisotropic random networks of semiflexible polymers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]