Gefeller, Olaf

[["dc.bibliographiccitation.firstpage","957"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PEDIATRICS"],["dc.bibliographiccitation.lastpage","964"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Herting, E."],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Land, M."],["dc.contributor.author","van Sonderen, L."],["dc.contributor.author","Harms, K."],["dc.contributor.author","Robertson, B."],["dc.date.accessioned","2018-11-07T08:44:53Z"],["dc.date.available","2018-11-07T08:44:53Z"],["dc.date.issued","2000"],["dc.description.abstract","Objective. Connatal pneumonia caused by group B streptococcal (GBS) infection may be associated with surfactant dysfunction. We investigated the effects of surfactant treatment in term and preterm neonates with GBS infection and respiratory failure, in comparison with corresponding data from a control population of noninfected infants heated with surfactant for respiratory distress syndrome (RDS). Design/Methods. The study comprised 118 infants with respiratory failure, clinical and/or laboratory signs of acute inflammatory disease, and GBS infection proven by culture results. They were recruited retrospectively from a database of patients treated with surfactant at 28 neonatology units participating in European multicenter trials (1987-1993) and prospectively from the same units in the following years. A nonrandomized control group of 236 noninfected infants was selected from the same database. The primary parameters evaluated were oxygen requirement, ventilator settings, and incidence of complications. Results. Median birth weight in the GBS study group was 1468 g (25th-75th percentiles: 1015-2170), and median gestational age was 30 (27-33) weeks. Thirty-one percent of the infants weighed >2000 g. Median age at surfactant treatment was 6 hours. The mean initial surfactant dose was 142 mg/kg (standard deviation: 53). Ninety of the infants were treated with Curosurf (Chiesi Farmaceutici, Parma, Italy), 13 with Survanta (Abboth GmbH, Wiesbaden, Germany), 12 with Alveofact (Dr Karl Thomae GmbH, Biberach, Germany), and 3 with Exosurf (Wellcome GmbH, Burgwedel, Germany). Within 1 hour of surfactant treatment, median fraction of inspiratory oxygen was reduced from .84 (25th-75th percentiles: .63-1.0) to .50 (.35-.80). The incidence of complications in the study group (mortality: 30%; pneumothorax: 16%; intracranial hemorrhage: 42%) was high, compared with infants with RDS. Conclusions. Surfactant therapy improves gas exchange in the majority of patients with GBS pneumonia. The response to surfactant is slower than in infants with RDS, and repeated surfactant doses are often needed. The mortality and morbidity are substantial, considering the relatively high mean birth weight of the treated infants."],["dc.identifier.doi","10.1542/peds.106.5.957"],["dc.identifier.isi","000165052300001"],["dc.identifier.pmid","11061760"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20297"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Acad Pediatrics"],["dc.relation.issn","0031-4005"],["dc.title","Surfactant treatment of neonates with respiratory failure and group B streptococcal infection"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","734"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","British Journal of Dermatology"],["dc.bibliographiccitation.lastpage","739"],["dc.bibliographiccitation.volume","158"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Hegewald, J."],["dc.contributor.author","Kraenke, Birger"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Pfahlberg, Annette"],["dc.date.accessioned","2018-11-07T11:16:21Z"],["dc.date.available","2018-11-07T11:16:21Z"],["dc.date.issued","2008"],["dc.description.abstract","Background Fluctuating irritability of the skin induced by low ambient temperature and humidity may compromise the reproducibility of patch testing. Objectives To assess the impact of temperature and absolute humidity at the time of patch testing on the occurrence of irritant or doubtful (IR/?), weak positive (+) and (strong) positive (++/+++) reactions, respectively, among 12 allergens included in the German Standard Series. Methods Analysis of clinical data collected in the surveillance network IVDK (http://www.ivdk.org) between January 1993 and December 2001 (n = 73 691 patients) combined with meteorological data obtained by the national services in Germany and Austria. Multinomial logistic regression analysis was used to estimate the risk associated with temperature, absolute humidity and vapour pressure, respectively, adjusted for sex, age, atopic dermatitis and duration of patch test application. Results For low temperature and humidity, a relevant increase of IR/? reaction frequency was observed in the cases of paraben mix and (chloro-) methylisothiazolinone. Both IR/? and + reactions were significantly increased with respect to the allergens fragrance mix, oil of turpentine, methyldibromo glutaronitrile + phenoxyethanol and particularly formaldehyde, while ++/+++ reactions were hardly affected by weather conditions. Conclusions The observed increase of IR/? reactions may be due to epidermal barrier function impairment. The impact of dry/cold weather on + reactions in terms of possibly false-positive reactions is restricted to few allergens. In the case of + reactions of unknown relevance, a re-test under warm conditions or verification tests such as the repeated open application test or the provocative use test may be recommendable."],["dc.identifier.doi","10.1111/j.1365-2133.2008.08448.x"],["dc.identifier.isi","000254122100010"],["dc.identifier.pmid","18284398"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54567"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0007-0963"],["dc.title","The impact of meteorological conditions on patch test results with 12 standard series allergens (fragrances, biocides, topical ingredients)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","32"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","39"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Gefeller, Olaf"],["dc.date.accessioned","2018-11-07T10:20:08Z"],["dc.date.available","2018-11-07T10:20:08Z"],["dc.date.issued","2002"],["dc.description.abstract","Clinical epidemiology (CE) is considered unable to estimate morbidity concerning either contact sensitization (CS) or allergic contact dermatitis (ACD) at the population level. Drug-utilization research (DUR) methods estimate the morbidity of suitable diseases based on prescription data for disease-specific drugs. Our objective was to estimate population figures for incidence and prevalence of ACD and CS based on sales data for patch test material in Germany and on patient data from the Information Network of Departments of Dermatology (IVDK). Approximately 600,000 standard series are sold per year in Germany, according to the 2 main manufacterers. This raw sales figure was corrected for certain effects (discarded preparations, proportion of formerly patch-tested patients, proportion of patients with ACD seeking medical advice) to obtain an estimate of the denominator of patients eligible for patch testing annually, and combined with patch test results from the Information Network of Departments of Dermatology (IVDK). In 17.8% (of 9,266 IVDK patients) ACD was established. Extrapolated to the general population, an incidence of ACD of between 1.7 and 7 per 1000 per year was estimated, depending on whether conservative or more liberal assumptions concerning the above effects were made. Of 78,067 IVDK patients tested between 1992 and 2000, 46.8% had at least 1 positive reaction (+ to + + +), and 22.7% had at least 1 stronger positive reaction (+ + or + + +).The 9-year prevalence of CS was estimated to lie between 4.0% and 16.6% for the first outcome, and between 2.0% and 8.1% for the second. Concerning single allergens, 1.9-4.5 million individuals are probably sensitized to nickel, and 1.4-3.4 million to fragrance mix among the German population of 82 million inhabitants. The morbidity data found in this study are in good accordance with data from population-based epidemiological studies. In comparison to these, the CE-DUR approach seems to be an economically feasible method to estimate continuously the population impact of ACD and CS."],["dc.identifier.doi","10.1034/j.1600-0536.2002.470107.x"],["dc.identifier.isi","000177965400007"],["dc.identifier.pmid","12225411"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41815"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley"],["dc.relation.issn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.title","Epidemiology of contact allergy: an estimation of morbidity employing the clinical epidemiology and drug-utilization research (CE-DUR) approach"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","118"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","125"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Kolmel, K. F."],["dc.contributor.author","Grange, John M."],["dc.contributor.author","Krone, Bernd"],["dc.contributor.author","Mastrangelo, Giuseppe"],["dc.contributor.author","Rossi, C. R."],["dc.contributor.author","Henz, B. M."],["dc.contributor.author","Seebacher, C."],["dc.contributor.author","Botev, I. N."],["dc.contributor.author","Niin, M."],["dc.contributor.author","Lambert, D."],["dc.contributor.author","Shafir, R."],["dc.contributor.author","Kokoschka, E. M."],["dc.contributor.author","Kleeberg, U. R."],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Pfahlberg, Annette"],["dc.date.accessioned","2018-11-07T08:38:20Z"],["dc.date.available","2018-11-07T08:38:20Z"],["dc.date.issued","2005"],["dc.description.abstract","There is increasing evidence that infections and vaccinations play an important role in the normal maturation of the immune system. It was therefore of interest to determine whether these immune events also affect the prognosis of melanoma patients. A cohort study of 542 melanoma patients in six European countries and Israel was conducted. Patients were followed up for a mean of 5 years and overall survival was recorded. Biometric evaluations included Kaplan-Meier estimates of survival over time and Hazard Ratios (HRs), taking into account all known prognostic factors. During the follow-up between 1993 and 2002, 182 of the 542 patients (34%) died. Survival curves, related to Breslow's thickness as the most important prognostic marker, were in accordance with those observed in previous studies where the cause of death was known to be due to disseminated melanoma. In a separate analysis of patients, vaccinated with vaccinia or Bacille Calmette-Guerin (BCG), HRs and the corresponding 95% Confidence Intervals (CIs) were 0.52 (0.34-0.79) and 0.69 (0.49-0.98), respectively. Joint analyses yielded HRs (and 95% CIs) of 0.55 (0.34-0.89) for patients vaccinated with vaccinia, 0.75 (0.30-1.86) with BCG, and 0.41 (0.25-0.69) with both vaccines. In contrast, infectious diseases occurring before the excision of the tumour had little, or, at the most, a minor influence on the outcome of the melanoma patients. These data reveal, for the first time, that vaccination with vaccinia in early life significantly prolongs the survival of patients with a malignant tumour after initial surgical management. BCG vaccination seems to have a similar, although weaker, effect. The underlying immune mechanisms involved remain to be determined. (C) 2004 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejca.2004.09.023"],["dc.identifier.isi","000226728700021"],["dc.identifier.pmid","15617996"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18747"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Prior immunisation of patients with malignant melanoma with vaccinia or BCG is associated with better survival. An European Organization for Research and Treatment of Cancer cohort study on 542 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","47"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","56"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.date.accessioned","2018-11-07T10:46:34Z"],["dc.date.available","2018-11-07T10:46:34Z"],["dc.date.issued","2004"],["dc.description.abstract","The present guidelines aim to support clinical researchers in adequately presenting data on contact allergy, and to use statistical tests appropriate for their data. A description of the mode of selection of patients, and of their relevant demographic details, is an essential prerequisite for the correct interpretation of study results. Proportions and rates, if regarded as estimate of these parameters of a target populations, should normally be supplemented with confidence intervals to address precision. Concordance, i.e., agreement between two ratings in a dependent sample, must be quantified with a chance-corrected measure such as Cohen's kappa coefficient. If the diagnostic quality of an outcome is being assessed, standard measures like sensitivity and specificity, as well as the prevalence-dependent positive and negative predictive values should be calculated. Often, contact allergy to a certain substance depends on several factors. In this situation, depending on the research question, techniques like stratification, standardization or multifactorial analysis should be employed. With increasing complexity of statistical description and analysis, consulting with a biostatistician is often mandatory."],["dc.identifier.doi","10.1111/j.0105-1873.2004.00406.x"],["dc.identifier.isi","000223954200001"],["dc.identifier.pmid","15373843"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47778"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0105-1873"],["dc.title","Guidelines for the descriptive presentation and statistical analysis of contact allergy data"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2372"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","2378"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Krone, Bernd"],["dc.contributor.author","Kolmel, K. F."],["dc.contributor.author","Grange, John M."],["dc.contributor.author","Mastrangelo, Giuseppe"],["dc.contributor.author","Henz, B. M."],["dc.contributor.author","Botev, I. N."],["dc.contributor.author","Niin, M."],["dc.contributor.author","Seebacher, C."],["dc.contributor.author","Lambert, D."],["dc.contributor.author","Shafir, R."],["dc.contributor.author","Kokoschka, E. M."],["dc.contributor.author","Kleeberg, U. R."],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Pfahlberg, Annette"],["dc.date.accessioned","2018-11-07T10:34:58Z"],["dc.date.available","2018-11-07T10:34:58Z"],["dc.date.issued","2003"],["dc.description.abstract",".A significant correlation between a reduced risk of melanoma and BCG and vaccinia vaccination in early childhood or infectious diseases later in life has already been reported from the FEBrile Infections and Melanoma (FEBIM) multicentre case-control study. This correlation is further evaluated in this study based on 603 incident cases of malignant melanoma and 627 population controls in six European countries and Israel by rneans of a joint analysis of the influence of vaccinations and infectious diseases. In addition, the previously unconsidered impact of influenza vaccinations is evaluated for the whole study population. The strong effects of the frequently given BCG and vaccinia vaccinations in early childhood, as well as of uncommon previous severe infectious diseases, were apparently not cumulative. With the Odds Ratio (OR) being set at I in the absence of vaccinations and infectious diseases, the OR dropped to 0.37 (95% Confidence Interval (CI): 0.10-1.42) when subjects had experienced one or more severe infectious diseases, associated with a fever of > 38.5 degreesC, and had not been vaccinated with BCG or vaccinia. The OR was 0.29 (CI: 0.15-0.57) in those who had had a severe infectious disease and were vaccinated with either BCG or vaccinia and 0.33 (CI: 0.17-0.65) for those with 1 or more severe infectious diseases and who had received both vaccinations. We conclude that both vaccinations as well as previous episodes of having a severe infectious disease induced the same protective mechanism with regards to the risk of melanoma. Because of a 'masking effect' by the vaccinia vaccination, the protective effect of the BCG vaccination and of certain infectious diseases against cancer has remained undetected. The vaccinations contributed more to the protection of the population than a previous episode of having an infectious disease. In view of the termination of vaccinations with vaccinia in all countries and of BCG in many of them, these findings call for a re-evaluation of vaccination strategies. (C) 2003 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0959-8049(03)00625-7"],["dc.identifier.isi","000186452000026"],["dc.identifier.pmid","14556930"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44991"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Impact of vaccinations and infectious diseases on the risk of melanoma - evaluation of an EORTC case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Archives of Allergy and Immunology"],["dc.bibliographiccitation.lastpage","240"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Hegewald, Janice"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Kraenke, Birger"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Pfahlberg, Annette"],["dc.date.accessioned","2018-11-07T11:20:04Z"],["dc.date.available","2018-11-07T11:20:04Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Nickel, cobalt and chromium are some of the most common causes of type IV sensitizations and subsequent allergic contact dermatitis. Accurate diagnosis of contact sensitization to these metal salts is made possible through standardized patch testing; however, patch tests with metal allergens may be influenced by meteorological conditions at the time of testing. We aimed to investigate how patch test reactions to these metals relate to outdoor temperature and humidity at the time of testing. Methods: Clinical patch test results from 61,435 patients tested at Austrian and German dermatology departments participating in a contact sensitization surveillance network (www.ivdk.org) from 1993 through 2001 were evaluated with weather data measured near the testing location and at the time of testing. Test reactions and ambient temperature and humidity were examined with multinomial logistic regression models. Results: The odds of irritant and doubtful reactions to all 3 ionized metals increased during cold/arid conditions, and the odds of weak allergic (positive) reactions to nickel and cobalt also increased during cold/dry weather. Strong allergic reactions were essentially independent of weather conditions. Conclusions: The increase in irritant and doubtful reactions coinciding with decreasing temperature and humidity may be the result of an overall increase in skin irritation brought about by these ambient conditions. The observed increases in erythematous and infiltrated ('weak allergic') reactions may be due to doubtful reactions increasing in intensity and being (falsely) classified as positive during colder and drier conditions. Copyright (c) 2008 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000142047"],["dc.identifier.isi","000260236900009"],["dc.identifier.pmid","18594154"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55444"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1018-2438"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Patch Test Results with Metals and Meteorological Conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","38"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Schnuch, Axel"],["dc.date.accessioned","2018-11-07T10:42:14Z"],["dc.date.available","2018-11-07T10:42:14Z"],["dc.date.issued","2003"],["dc.description.abstract","To quantify the independent impact of potential risk factors for nickel contact allergy (NCA), a multifactorial Poisson regression analysis of standardized anamnestic and patch test data (with nickel sulfate, 5% in petrolatum) was performed, comprising 74 940 patients assessed in the 33 German and Austrian contact dermatitis units of the Information Network of Departments of Dermatology (IVDK) between 1992 and 2000. NCA was observed in 15.5% patients. Female sex was the strongest risk factor (prevalence ratio 3.74, 95% CI: 3.51-3.98). Risk increased monotonically and significantly with decreasing age. Atopic dermatitis was not a risk factor. The year of patch test had no influence on NCA risk. Significant variation of risk between occupations was observed. In conclusion, our multifactorial analysis was able to quantify the impact of established risk factors and additionally address other, e.g. occupational, factors yet unidentified."],["dc.identifier.doi","10.1034/j.1600-0536.46.s4.29_102.x"],["dc.identifier.isi","000181633600006"],["dc.identifier.pmid","12641576"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46742"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0105-1873"],["dc.title","Risk factors for contact allergy to nickel - results of a multifactorial analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2915"],["dc.bibliographiccitation.issue","4B"],["dc.bibliographiccitation.journal","Anticancer Research"],["dc.bibliographiccitation.lastpage","2920"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Efferth, T."],["dc.contributor.author","Schulten, H. G."],["dc.contributor.author","Thelen, Paul"],["dc.contributor.author","Bode, M. E."],["dc.contributor.author","Beniers, AJMC"],["dc.contributor.author","Granzen, Bernd"],["dc.contributor.author","Ringert, Rolf-Hermann"],["dc.contributor.author","Mertens, R."],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Jakse, G."],["dc.contributor.author","Fuzesi, Laszlo"],["dc.date.accessioned","2018-11-07T08:53:28Z"],["dc.date.available","2018-11-07T08:53:28Z"],["dc.date.issued","2001"],["dc.description.abstract","Nephroblastomas (Wilms' tumors) are curable with survival rates above 80%. Nevertheless, some tumors fail to respond to therapy and those patients have a poor prognosis. Prognostic factors for nephroblastomas have still not been satisfactorily explored. In an effort to unravel molecular markers for non-responding nephroblastomas, we investigated by means of immunohistochemistry the expression of heat-shock protein 70 (HSP70) in formalin-fixed and paraffin-embedded tissue samples from 32 children afflicted with nephroblastoma. The results were validated using real-time RT-PCR. HSP70 expression was confined to blastemal and epithelial components, while the tumor stroma was negative. HSP70 expression was greater, if the tumors had been chemotherapeutically treated prior to operation, indicating that cytostatic drugs induce HSP70. Furthermore, high HSP70 expression was confined to tumors from children who survived, whereas tumors from dead patients were negative or weakly-positive for HSP70. Though the number of cases analyzed was small, they provide an indication that HSP70 expression may be of prognostic value."],["dc.identifier.isi","000171985000010"],["dc.identifier.pmid","11712786"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22418"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Int Inst Anticancer Research"],["dc.relation.issn","0250-7005"],["dc.title","Differential expression of the heat shock protein 70 in the histological compartments of nephroblastomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S32"],["dc.bibliographiccitation.journal","Das Gesundheitswesen"],["dc.bibliographiccitation.lastpage","S34"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Schwanitz, H. J."],["dc.date.accessioned","2018-11-07T09:19:22Z"],["dc.date.available","2018-11-07T09:19:22Z"],["dc.date.issued","2001"],["dc.description.abstract","The incidence of occupational dermatitis of the hands is particularly high in the hairdressing trade. To elucidate the role of various risk factors, and to ultimately improve primary prevention of occupational hand dermatitis, a prospective cohort study was conducted between 1992 and 1997, including 2352 hairdressing trainees. Already six weeks after the start of training (median) 35.4% had - usually mild - irritant skin changes, mainly involving the interdigital web spaces. These were associated with subsequent, possibly more severe, hand dermatitis. Reduced exposure to wet work, i.e., improved skin protection with gloves, often led to the resolution of dermatitis of the hands. In conclusion, early irritant skin damage is a sentinel event that heralds possibly disabling occupational skin disease and should prompt adequate preventive measures."],["dc.identifier.isi","000168118500008"],["dc.identifier.pmid","11329916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28618"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0941-3790"],["dc.title","Prevention of skin damage in hairdressers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]