Czesnik, Dirk

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of the Neurological Sciences"],["dc.bibliographiccitation.lastpage","109"],["dc.bibliographiccitation.volume","354"],["dc.contributor.author","Wickmann, Franziska"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Timaeus, Charles"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.date.accessioned","2018-11-07T09:54:38Z"],["dc.date.available","2018-11-07T09:54:38Z"],["dc.date.issued","2015"],["dc.description.abstract","The present study aimed to investigate the efficacy of repetitive cathodal direct current stimulation (rctDCS) over the visual cortex as a prophylactic treatment in patients with menstrual migraine. 20 female patients were recruited in this double-blind, placebo-controlled study and were assigned to receive either cathodal or sham stimulation. Over 3 menstrual cycles, tDCS with 2 mA intensity and 20 min duration was applied to the visual cortex of the patients, in 5 consecutive sessions 1-5 days prior to the first day of their menstruation. The primary endpoint of the study was the frequency of the migraine attacks at the end of the treatment period, however, additional parameters, such as the number of migraine related days and the intensity of pain were also recorded 3 months before, during and 3 months post-treatment Visual cortex excitability was determined by measuring the phosphene thresholds (PTs) using single pulse transcranial magnetic stimulation (TMS) over the visual cortex. Sixteen patients completed the study. A significant decrease in the number of migraine attacks (p = 0.04) was found in the cathodal group compared to baseline but not compared to sham (p = 0.053). In parallel the PTs increased significantly in this group, compared to the sham group (p < 0.05). Our results indicate that prophylactic treatment with rctDCS over the visual cortex might be able to decrease the number of attacks in patients with menstrual migraine, probably by modifying cortical excitability. (C) 2015 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","Migraine Foundation"],["dc.identifier.doi","10.1016/j.jns.2015.05.009"],["dc.identifier.isi","000356978600018"],["dc.identifier.pmid","26003225"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36574"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1878-5883"],["dc.relation.issn","0022-510X"],["dc.title","Prophylactic treatment in menstrual migraine: A proof-of-concept study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","865"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Infection and Immunity"],["dc.bibliographiccitation.lastpage","871"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Ebert, Sandra"],["dc.contributor.author","Regen, Tommy"],["dc.contributor.author","Agarwal, Amit"],["dc.contributor.author","Tauber, Simone C."],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Bunkowski, Stephanie"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Hanisch, Uwe-Karsten"],["dc.contributor.author","Hammerschmidt, Sven"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-11-07T08:46:16Z"],["dc.date.available","2018-11-07T08:46:16Z"],["dc.date.issued","2010"],["dc.description.abstract","Toll-like receptors (TLRs) are crucial pattern recognition receptors in innate immunity that are expressed in microglia, the resident macrophages of the brain. TLR2, -4, and -9 are important in the responses against Streptococcus pneumoniae, the most common agent causing bacterial meningitis beyond the neonatal period. Murine microglial cultures were stimulated with agonists for TLR1/2 (Pam3CSK4), TLR4 (lipopolysaccharide), and TLR9 (CpG oligodeoxynucleotide) for 24 h and then exposed to either the encapsulated D39 (serotype 2) or the nonencapsulated R6 strain of S. pneumoniae. After stimulation, the levels of interleukin-6 and CCL5 (RANTES [regulated upon activation normal T-cell expressed and secreted]) were increased, confirming microglial activation. The TLR1/2, -4, and -9 agonist-stimulated microglia ingested significantly more bacteria than unstimulated cells (P < 0.05). The presence of cytochalasin D, an inhibitor of actin polymerizaton, blocked >90% of phagocytosis. Along with an increased phagocytic activity, the intracellular bacterial killing was also increased in TLR-stimulated cells compared to unstimulated cells. Together, our data suggest that microglial stimulation by these TLRs may increase the resistance of the brain against pneumococcal infections."],["dc.identifier.doi","10.1128/IAI.01110-09"],["dc.identifier.isi","000273855600033"],["dc.identifier.pmid","19933834"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20648"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","0019-9567"],["dc.title","Toll-Like Receptor Stimulation Enhances Phagocytosis and Intracellular Killing of Nonencapsulated and Encapsulated Streptococcus pneumoniae by Murine Microglia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3063"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","3080"],["dc.bibliographiccitation.volume","591"],["dc.contributor.author","Howells, James"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Trevillion, Louise"],["dc.contributor.author","Burke, David"],["dc.date.accessioned","2018-11-07T09:24:00Z"],["dc.date.available","2018-11-07T09:24:00Z"],["dc.date.issued","2013"],["dc.description.abstract","Key points center dot In six healthy subjects, the excitability of both motor and sensory axons was altered during hyperthermia, lowering their safety margin. center dot The results suggest that slow K+ channels play a significant role in these changes in axonal excitability during hyperthermia. center dot Inward rectification was reduced during hyperthermia, and the modelling suggests that the hyperpolarization-activated cation current, Ih, was reduced, thus hampering its ability to counter activity-dependent hyperpolarization. center dot Hyperthermia lowers the safety margin for action potential generation and propagation. Differences in their responses to hyperthermia suggest that motor axons undergo conduction block more readily than sensory axons during fever, particularly when the safety margin is already impaired. Abstract Hyperthermia challenges the nervous system's ability to transmit action potentials faithfully. Neuromuscular diseases, particularly those involving demyelination have an impaired safety margin for action potential generation and propagation, and symptoms are commonly accentuated by increases in temperature. The aim of this study was to examine the mechanisms responsible for reduced excitability during hyperthermia. Additionally, we sought to determine if motor and sensory axons differ in their propensity for conduction block during hyperthermia. Recordings of axonal excitability were performed at normal temperatures and during focal hyperthermia for motor and sensory axons in six healthy subjects. There were clear changes in excitability during hyperthermia, with reduced superexcitability following an action potential, faster accommodation to long-lasting depolarization and reduced accommodation to hyperpolarization. A verified model of human motor and sensory axons was used to clarify the effects of hyperthermia. The hyperthermia-induced changes in excitability could be accounted for by increasing the modelled temperature by 6 degrees C (and adjusting the maximum conductances and activation kinetics according to their Q10 values; producing a 2 mV hyperpolarization of resting membrane potential), further hyperpolarizing the voltage dependence of Ih (motor, 11 mV; sensory, 7 mV) and adding a small depolarizing current at the internode (motor, 20 pA; sensory, 30 pA). The modelling suggested that slow K+ channels play a significant role in reducing axonal excitability during hyperthermia. The further hyperpolarization of the activation of Ih would limit its ability to counter the hyperpolarization produced by activity, thereby allowing conduction block to occur during hyperthermia."],["dc.identifier.doi","10.1113/jphysiol.2012.249060"],["dc.identifier.isi","000320398000009"],["dc.identifier.pmid","23613528"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29723"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0022-3751"],["dc.title","Excitability and the safety margin in human axons during hyperthermia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11193"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","International Journal of Environmental Research and Public Health"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Veiz, Elisabeth"],["dc.contributor.author","Kieslich, Susann-Kristin"],["dc.contributor.author","Staab, Julia"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Meyer, Thomas"],["dc.date.accessioned","2021-12-01T09:22:50Z"],["dc.date.available","2021-12-01T09:22:50Z"],["dc.date.issued","2021"],["dc.description.abstract","This paper presents data from a transcutaneous vagus nerve stimulation experiment that point towards a blunted cardiac baroreceptor sensitivity (cBRS) in young males compared to females during electrical stimulation of the forearm and a rhythmic breathing task. Continuous electrocardiography, impedance cardiography and continuous blood-pressure recordings were assessed in a sex-matched cohort of twenty young healthy subjects. Electrical stimulation of the median nerve was conducted by using a threshold-tracking method combined with two rhythmic breathing tasks (0.1 and 0.2 Hz) before, during and after active or sham transcutaneous vagus nerve stimulation. Autonomic and hemodynamic parameters were calculated, and differences were analyzed by using linear mixed models and post hoc F-tests. None of the autonomic and hemodynamic parameters differed between the sham and active conditions. However, compared to females, male participants had an overall lower total cBRS independent of stimulation condition during nerve stimulation (females: 14.96 ± 5.67 ms/mmHg, males: 11.89 ± 3.24 ms/mmHg, p = 0.031) and rhythmic breathing at 0.2 Hz (females: 21.49 ± 8.47 ms/mmHg, males: 15.12 ± 5.70 ms/mmHg, p = 0.004). Whereas vagus nerve stimulation at the left inner tragus did not affect the efferent vagal control of the heart, we found similar patterns of baroreceptor sensitivity activation over the stimulation period in both sexes, which, however, significantly differed in their magnitude, with females showing an overall higher cBRS."],["dc.description.abstract","This paper presents data from a transcutaneous vagus nerve stimulation experiment that point towards a blunted cardiac baroreceptor sensitivity (cBRS) in young males compared to females during electrical stimulation of the forearm and a rhythmic breathing task. Continuous electrocardiography, impedance cardiography and continuous blood-pressure recordings were assessed in a sex-matched cohort of twenty young healthy subjects. Electrical stimulation of the median nerve was conducted by using a threshold-tracking method combined with two rhythmic breathing tasks (0.1 and 0.2 Hz) before, during and after active or sham transcutaneous vagus nerve stimulation. Autonomic and hemodynamic parameters were calculated, and differences were analyzed by using linear mixed models and post hoc F-tests. None of the autonomic and hemodynamic parameters differed between the sham and active conditions. However, compared to females, male participants had an overall lower total cBRS independent of stimulation condition during nerve stimulation (females: 14.96 ± 5.67 ms/mmHg, males: 11.89 ± 3.24 ms/mmHg, p = 0.031) and rhythmic breathing at 0.2 Hz (females: 21.49 ± 8.47 ms/mmHg, males: 15.12 ± 5.70 ms/mmHg, p = 0.004). Whereas vagus nerve stimulation at the left inner tragus did not affect the efferent vagal control of the heart, we found similar patterns of baroreceptor sensitivity activation over the stimulation period in both sexes, which, however, significantly differed in their magnitude, with females showing an overall higher cBRS."],["dc.identifier.doi","10.3390/ijerph182111193"],["dc.identifier.pii","ijerph182111193"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94492"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.publisher","MDPI"],["dc.relation.eissn","1660-4601"],["dc.rights","Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","254"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Klinische Neurophysiologie"],["dc.bibliographiccitation.lastpage","255"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Czesnik, D."],["dc.date.accessioned","2018-11-07T08:49:13Z"],["dc.date.available","2018-11-07T08:49:13Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1055/s-0031-1285853"],["dc.identifier.isi","000298156300010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21407"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1434-0275"],["dc.title","Report on Experience with the Project \"Study of the Regulation of Axonal Excitability in Peripheral Sensory and Motor Axons by Means of the Threshold Tracking Methods\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Rabba, J."],["dc.contributor.author","Czesnik, D."],["dc.contributor.author","Nezlin, L."],["dc.contributor.author","Mueller, B."],["dc.contributor.author","Schild, Detlev"],["dc.date.accessioned","2018-11-07T11:04:38Z"],["dc.date.available","2018-11-07T11:04:38Z"],["dc.date.issued","2000"],["dc.format.extent","374"],["dc.identifier.isi","000088236602132"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51886"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.issn","0953-816X"],["dc.title","Alpha-2-receptors modulate calcium currents and synaptic transmission in the olfactory bulb of Xenopus laevis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","American Journal of Otolaryngology"],["dc.bibliographiccitation.lastpage","74"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T09:30:43Z"],["dc.date.available","2018-11-07T09:30:43Z"],["dc.date.issued","2013"],["dc.description.abstract","We report on a 61-year-old woman with cupulolithiasis of the right horizontal semicircular canal, which is usually difficult to treat. The patient reported that several years ago, similar symptoms relieved completely after having performed several somersaults together with her granddaughter. This time, repetitive somersaults were again effective to treat her benign paroxysmal positional vertigo. Acceleration during a somersault may induce an intracanalicular force strong enough to detach otoconia debris from the cupula. Rolling may then promote their reentrance into the utricle. This case suggests that repetitive somersaults may be an alternative treatment of cupulolithiasis of the horizontal semicircular canal. (C) 2013 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.amjoto.2012.07.002"],["dc.identifier.isi","000312571200014"],["dc.identifier.pmid","22999308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31372"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","0196-0709"],["dc.title","Granddaughter's somersault treats cupulolithiasis of the horizontal semicircular canal"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Chemical Senses"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Manzini, Ivan"],["dc.contributor.author","Czesnik, D."],["dc.contributor.author","Kuduz, Josko"],["dc.contributor.author","Schild, Detlev"],["dc.date.accessioned","2018-11-07T09:43:57Z"],["dc.date.available","2018-11-07T09:43:57Z"],["dc.date.issued","2006"],["dc.format.extent","A12"],["dc.identifier.isi","000238761600049"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34291"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","28th Annual Meeting of the Association-for-Chemoreception-Sciences"],["dc.relation.eventlocation","Sarasota, FL"],["dc.relation.issn","0379-864X"],["dc.title","Dual effect of ATP in the olfactory epithelium of Xenopus laevis tadpoles: Activation of both receptor and sustentacular supporting cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","443"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Genetics in Medicine"],["dc.bibliographiccitation.lastpage","451"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Pehlivan, Davut"],["dc.contributor.author","Beck, Christine R."],["dc.contributor.author","Okamoto, Yuji"],["dc.contributor.author","Harel, Tamar"],["dc.contributor.author","Akdemir, Zeynep H. C."],["dc.contributor.author","Jhangiani, Shalini N."],["dc.contributor.author","Withers, Marjorie A."],["dc.contributor.author","Goksungur, Meryem Tuba"],["dc.contributor.author","Carvalho, Claudia M. B."],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Gonzaga-Jauregui, Claudia"],["dc.contributor.author","Wiszniewski, Wojciech"],["dc.contributor.author","Muzny, Donna M."],["dc.contributor.author","Gibbs, Richard A."],["dc.contributor.author","Rautenstrauss, Bernd"],["dc.contributor.author","Sereda, Michael W."],["dc.contributor.author","Lupski, James R."],["dc.date.accessioned","2018-11-07T10:15:09Z"],["dc.date.available","2018-11-07T10:15:09Z"],["dc.date.issued","2016"],["dc.description.abstract","Purpose: Charcot-Marie-Tooth (CMT) disease is a heterogeneous group of genetic disorders of the peripheral nervous system. Copy-number variants (CNVs) contribute significantly to CMT, as duplication of PMP22 underlies the majority of CMT1 cases. We hypothesized that CNVs and/or single-nucleotide variants (SNVs) might exist in patients with CMT with an unknown molecular genetic etiology. Methods: Two hundred patients with CMT, negative for both SNV mutations in several CMT genes and for CNVs involving PMP22, were screened for CNVs by high-resolution oligonucleotide array comparative genomic hybridization. Whole-exome sequencing was conducted on individuals with rare, potentially pathogenic CNVs. Results: Putatively causative CNVs were identified in five subjects (similar to 2.5%); four of the five map to known neuropathy genes. Breakpoint sequencing revealed Alu-Alu-mediated junctions as a predominant contributor. Exome sequencing identified MFN2 SNVs in two of the individuals. Conclusion: Neuropathy-associated CNV outside of the PMP22 locus is rare in CMT. Nevertheless, there is potential clinical utility in testing for CNVs and exome sequencing in CMT cases negative for the CMT1A duplication. These findings suggest that complex phenotypes including neuropathy can potentially be caused by a combination of SNVs and CNVs affecting more than one disease-associated locus and contributing to a mutational burden."],["dc.identifier.doi","10.1038/gim.2015.124"],["dc.identifier.isi","000375263600004"],["dc.identifier.pmid","26378787"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40754"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1530-0366"],["dc.relation.issn","1098-3600"],["dc.title","The role of combined SNV and CNV burden in patients with distal symmetric polyneuropathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Fledrich, Robert"],["dc.contributor.author","Stassart, Ruth Martha"],["dc.contributor.author","Haag, Lea-Maxie"],["dc.contributor.author","Veselcic, P."],["dc.contributor.author","Czesnik, D."],["dc.contributor.author","Nave, K.-A."],["dc.contributor.author","Sereda, Michael W."],["dc.date.accessioned","2018-11-07T09:23:22Z"],["dc.date.available","2018-11-07T09:23:22Z"],["dc.date.issued","2013"],["dc.format.extent","S198"],["dc.identifier.isi","000320408400638"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29560"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","11th European Meeting on Glial Cell Function in Health and Disease"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0894-1491"],["dc.title","NEUREGULIN-1 TYPE I ENHANCES FUNCTIONAL RECOVERY AFTER ACUTE PERIPHERAL NERVE INJURY AND RESCUES AXONAL LOSS IN A MOUSE MODEL FOR CHARCOT MARIE TOOTH DISEASE 1A"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]