Hartmann, Magnus

[["dc.bibliographiccitation.firstpage","120"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Astronomical Journal"],["dc.bibliographiccitation.volume","155"],["dc.contributor.author","Hatzes, A. P."],["dc.contributor.author","Endl, M."],["dc.contributor.author","Cochran, W. D."],["dc.contributor.author","MacQueen, P. J."],["dc.contributor.author","Han, I."],["dc.contributor.author","Lee, B.-C."],["dc.contributor.author","Kim, K.-M."],["dc.contributor.author","Mkrtichian, D."],["dc.contributor.author","Döllinger, M."],["dc.contributor.author","Hartmann, M."],["dc.contributor.author","Karjalainen, M."],["dc.contributor.author","Dreizler, S."],["dc.date.accessioned","2020-12-10T18:47:33Z"],["dc.date.available","2020-12-10T18:47:33Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3847/1538-3881/aaa8e1"],["dc.identifier.eissn","1538-3881"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78800"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The Radial Velocity Variability of the K-giant γ Draconis: Stellar Variability Masquerading as a Planet"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","81"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","Journal of Comparative Pathology"],["dc.bibliographiccitation.lastpage","91"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Mätz-Rensing, K."],["dc.contributor.author","Hartmann, T."],["dc.contributor.author","Wendel, G.M."],["dc.contributor.author","Frick, J.S."],["dc.contributor.author","Homolka, S."],["dc.contributor.author","Richter, E."],["dc.contributor.author","Munk, M.H."],["dc.contributor.author","Kaup, F.-J."],["dc.date.accessioned","2022-10-06T13:33:10Z"],["dc.date.available","2022-10-06T13:33:10Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1016/j.jcpa.2015.05.006"],["dc.identifier.pii","S0021997515000985"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115564"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0021-9975"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Outbreak of Tuberculosis in a Colony of Rhesus Monkeys (Macaca mulatta) after Possible Indirect Contact with a Human TB Patient"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","561"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.lastpage","570.e6"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Chowdhury, Arpita"],["dc.contributor.author","Aich, Abhishek"],["dc.contributor.author","Jain, Gaurav"],["dc.contributor.author","Wozny, Katharina"],["dc.contributor.author","Lüchtenborg, Christian"],["dc.contributor.author","Hartmann, Magnus"],["dc.contributor.author","Bernhard, Olaf"],["dc.contributor.author","Balleiniger, Martina"],["dc.contributor.author","Alfar, Ezzaldin Ahmed"],["dc.contributor.author","Zieseniß, Anke"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Rizzoli, Silvio O."],["dc.contributor.author","Brügger, Britta"],["dc.contributor.author","Fischer, Andrè"],["dc.contributor.author","Katschinski, Dörthe M."],["dc.contributor.author","Rehling, Peter"],["dc.contributor.author","Dudek, Jan"],["dc.date.accessioned","2019-01-17T15:41:24Z"],["dc.date.available","2019-01-17T15:41:24Z"],["dc.date.issued","2018"],["dc.description.abstract","Summary: Mitochondria fulfill vital metabolic functions and act as crucial cellular signaling hubs, integrating their metabolic status into the cellular context. Here, we show that defective cardiolipin remodeling, upon loss of the cardiolipin acyl transferase tafazzin, decreases HIF-1α signaling in hypoxia. Tafazzin deficiency does not affect posttranslational HIF-1α regulation but rather HIF-1α gene expression, a dysfunction recapitulated in iPSC-derived cardiomyocytes from Barth syndrome patients with tafazzin deficiency. RNA-seq analyses confirmed drastically altered signaling in tafazzin mutant cells. In hypoxia, tafazzin-deficient cells display reduced production of reactive oxygen species (ROS) perturbing NF-κB activation and concomitantly HIF-1α gene expression. Tafazzin-deficient mice hearts display reduced HIF-1α levels and undergo maladaptive hypertrophy with heart failure in response to pressure overload challenge. We conclude that defective mitochondrial cardiolipin remodeling dampens HIF-1α signaling due to a lack of NF-κB activation through reduced mitochondrial ROS production, decreasing HIF-1α transcription."],["dc.identifier.doi","10.1016/j.celrep.2018.09.057"],["dc.identifier.pmid","30332638"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15391"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57349"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/237"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A06: Molekulare Grundlagen mitochondrialer Kardiomyopathien"],["dc.relation","SFB 1002 | D04: Bedeutung der Methylierung von RNA (m6A) und des Histons H3 (H3K4) in der Herzinsuffizienz"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation.issn","2211-1247"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.relation.workinggroup","RG Guan (Application of patient-specific induced pluripotent stem cells in disease modelling)"],["dc.relation.workinggroup","RG Rehling (Mitochondrial Protein Biogenesis)"],["dc.relation.workinggroup","RG Toischer (Kardiales Remodeling)"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],["dc.contributor.author","Dudek, Jan"],["dc.contributor.author","Hartmann, Magnus"],["dc.contributor.author","Rehling, Peter"],["dc.date.accessioned","2019-02-26T11:19:36Z"],["dc.date.available","2019-02-26T11:19:36Z"],["dc.date.issued","2018"],["dc.description.abstract","Mitochondria play an essential role in the energy metabolism of the heart. Many of the essential functions are associated with mitochondrial membranes and oxidative phosphorylation driven by the respiratory chain. Mitochondrial membranes are unique in the cell as they contain the phospholipid cardiolipin. The important role of cardiolipin in cardiovascular health is highlighted by several cardiac diseases, in which cardiolipin plays a fundamental role. Barth syndrome, Sengers syndrome, and Dilated cardiomyopathy with ataxia (DCMA) are genetic disorders, which affect cardiolipin biosynthesis. Other cardiovascular diseases including ischemia/reperfusion injury and heart failure are also associated with changes in the cardiolipin pool. Here, we summarize molecular functions of cardiolipin in mitochondrial biogenesis and morphology. We highlight the role of cardiolipin for the respiratory chain, metabolite carriers, and mitochondrial metabolism and describe links to apoptosis and mitochondria specific autophagy (mitophagy) with possible implications in cardiac disease."],["dc.identifier.doi","10.1016/j.bbadis.2018.08.025"],["dc.identifier.pmid","30837070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57616"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/226"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/38"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A06: Molekulare Grundlagen mitochondrialer Kardiomyopathien"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P13: Protein Transport über den mitochondrialen Carrier Transportweg"],["dc.relation.issn","0925-4439"],["dc.relation.workinggroup","RG Rehling (Mitochondrial Protein Biogenesis)"],["dc.title","The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","693"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Monatsschrift Kinderheilkunde"],["dc.bibliographiccitation.lastpage","702"],["dc.bibliographiccitation.volume","168"],["dc.contributor.author","Hoyer-Kuhn, H."],["dc.contributor.author","Brockmann, K."],["dc.contributor.author","Hartmann, M."],["dc.contributor.author","Hofmann, C."],["dc.contributor.author","Holl-Wieden, A."],["dc.contributor.author","Haas, J.-P."],["dc.date.accessioned","2021-04-14T08:26:13Z"],["dc.date.available","2021-04-14T08:26:13Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00112-020-00931-x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81870"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1433-0474"],["dc.relation.issn","0026-9298"],["dc.title","Bewegungsstörungen bei chronischen Erkrankungen"],["dc.title.translated","Movement disorders in chronic diseases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]