Meyer, Tim

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[["dc.bibliographiccitation.firstpage","43"],["dc.bibliographiccitation.journal","Australian and New Zealand Journal of Psychiatry"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Zepf, Florian D."],["dc.contributor.author","Wang, B."],["dc.contributor.author","Isensee, Corinna"],["dc.contributor.author","Becker, A."],["dc.contributor.author","Wong, J."],["dc.contributor.author","Eastwood, Peter R."],["dc.contributor.author","Huang, R."],["dc.contributor.author","Runions, Kevin C."],["dc.contributor.author","Stewart, R."],["dc.contributor.author","Meyer, T."],["dc.contributor.author","Bruni, L."],["dc.contributor.author","Rothenberger, A."],["dc.date.accessioned","2018-11-07T10:24:00Z"],["dc.date.available","2018-11-07T10:24:00Z"],["dc.date.issued","2017"],["dc.identifier.isi","000403466600106"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42576"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.issn","1440-1614"],["dc.relation.issn","0004-8674"],["dc.title","DEVELOPMENTAL TRAJECTORIES OF SLEEP PROBLEMS FROM CHILDHOOD TO ADOLESCENCE BOTH PREDICT AND ARE PREDICTED BY EMOTIONAL AND BEHAVIOURAL PROBLEMS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.journal","Progress in Biophysics and Molecular Biology"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Schlick, Susanne F."],["dc.contributor.author","Spreckelsen, Florian"],["dc.contributor.author","Tiburcy, Malte"],["dc.contributor.author","Iyer, Lavanya M."],["dc.contributor.author","Meyer, Tim"],["dc.contributor.author","Zelarayan, Laura C."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.contributor.author","Rehfeldt, Florian"],["dc.date.accessioned","2020-12-10T15:20:42Z"],["dc.date.available","2020-12-10T15:20:42Z"],["dc.date.issued","2019"],["dc.description.abstract","Cardiomyocyte and stroma cell cross-talk is essential for the formation of collagen-based engineered heart muscle, including engineered human myocardium (EHM). Fibroblasts are a main component of the myocardial stroma. We hypothesize that fibroblasts, by compacting the surrounding collagen network, support the self-organization of cardiomyocytes into a functional syncytium. With a focus on early self-organization processes in EHM, we studied the molecular and biophysical adaptations mediated by defined populations of fibroblasts and embryonic stem cell-derived cardiomyocytes in a collagen type I hydrogel. After a short phase of cell-independent collagen gelation (30 min), tissue compaction was progressively mediated by fibroblasts. Fibroblast-mediated tissue stiffening was attenuated in the presence of cardiomyocytes allowing for the assembly of stably contracting, force-generating EHM within 4 weeks. Comparative RNA-sequencing data corroborated that fibroblasts are particularly sensitive to the tissue compaction process, resulting in the fast activation of transcription profiles, supporting heart muscle development and extracellular matrix synthesis. Large amplitude oscillatory shear (LAOS) measurements revealed nonlinear strain stiffening at physiological strain amplitudes (>2%), which was reduced in the presence of cells. The nonlinear stress-strain response could be characterized by a mathematical model. Collectively, our study defines the interplay between fibroblasts and cardiomyocytes during human heart muscle self-organization in vitro and underscores the relevance of fibroblasts in the biological engineering of a cardiomyogenesis-supporting viscoelastic stroma. We anticipate that the established mathematical model will facilitate future attempts to optimize EHM for in vitro (disease modelling) and in vivo applications (heart repair)."],["dc.identifier.doi","10.1016/j.pbiomolbio.2018.11.011"],["dc.identifier.pmid","30553553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72769"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/248"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.relation.workinggroup","RG Tiburcy (Stem Cell Disease Modeling)"],["dc.relation.workinggroup","RG Zelarayán-Behrend (Developmental Pharmacology)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.rights","CC BY 4.0"],["dc.title","Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Progress in Biophysics and Molecular Biology"],["dc.bibliographiccitation.lastpage","2"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Tarantola, Marco"],["dc.contributor.author","Meyer, Tim"],["dc.contributor.author","Schmidt, Christoph F."],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.date.accessioned","2020-12-10T15:20:42Z"],["dc.date.available","2020-12-10T15:20:42Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.pbiomolbio.2019.03.009"],["dc.identifier.issn","0079-6107"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72770"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Physics meets medicine - At the heart of active matter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","478"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Herz"],["dc.bibliographiccitation.lastpage","483"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Leibing, Enic"],["dc.contributor.author","Meyer, T."],["dc.date.accessioned","2018-11-07T10:09:30Z"],["dc.date.available","2018-11-07T10:09:30Z"],["dc.date.issued","2016"],["dc.description.abstract","Owing to its acute psychotropic effects, ethanol is the most frequently consumed toxic agent worldwide. However, excessive alcohol intake results in an array of health, social, and economic consequences, which are related to its property as an addictive substance. It has been well established that exposure to high levels of alcohol for a long period leads to the onset and progression of nonischemic cardiomyopathy through direct toxic mechanisms of ethanol and its metabolite, acetaldehyde. Excessive alcohol ingestion causes myocardial damage including disruptions of the myofibrillar architecture and is associated with reduced myocardial contractility and decreased ejection volumes. Key features of alcoholic cardiomyopathy are cardiac hypertrophy and ventricular dilatation, and the disease is manifested mainly as cardiomegaly, congestive heart failure, and even cardiac death. Mechanisms that have been postulated to underlie the pathogenesis of alcoholic cardiomyopathy include apoptosis, mitochondrial alterations, acetaldehyde protein adduct formation, oxidative stress, and imbalances in fatty acid metabolism. In the following, we give a brief overview of the molecular effects of ethanol-metabolizing enzymes and their impact on myocardial signal transduction pathways."],["dc.identifier.doi","10.1007/s00059-016-4459-8"],["dc.identifier.isi","000382886400004"],["dc.identifier.pmid","27418001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39661"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","1615-6692"],["dc.relation.issn","0340-9937"],["dc.title","Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e33931"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Hensen, Ulf"],["dc.contributor.author","Meyer, Tim"],["dc.contributor.author","Haas, Jürgen"],["dc.contributor.author","Rex, René"],["dc.contributor.author","Vriend, Gert"],["dc.contributor.author","Grubmüller, Helmut"],["dc.date.accessioned","2017-09-07T11:48:52Z"],["dc.date.available","2017-09-07T11:48:52Z"],["dc.date.issued","2012"],["dc.description.abstract","Proteins are usually described and classified according to amino acid sequence, structure or function. Here, we develop a minimally biased scheme to compare and classify proteins according to their internal mobility patterns. This approach is based on the notion that proteins not only fold into recurring structural motifs but might also be carrying out only a limited set of recurring mobility motifs. The complete set of these patterns, which we tentatively call the dynasome, spans a multidimensional space with axes, the dynasome descriptors, characterizing different aspects of protein dynamics. The unique dynamic fingerprint of each protein is represented as a vector in the dynasome space. The difference between any two vectors, consequently, gives a reliable measure of the difference between the corresponding protein dynamics. We characterize the properties of the dynasome by comparing the dynamics fingerprints obtained from molecular dynamics simulations of 112 proteins but our approach is, in principle, not restricted to any specific source of data of protein dynamics. We conclude that: 1. the dynasome consists of a continuum of proteins, rather than well separated classes. 2. For the majority of proteins we observe strong correlations between structure and dynamics. 3. Proteins with similar function carry out similar dynamics, which suggests a new method to improve protein function annotation based on protein dynamics."],["dc.identifier.doi","10.1371/journal.pone.0033931"],["dc.identifier.gro","3142536"],["dc.identifier.isi","000305338200004"],["dc.identifier.pmid","22606222"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8898"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1932-6203"],["dc.title","Exploring Protein Dynamics Space: The Dynasome as the Missing Link between Protein Structure and Function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Psychosomatic Research"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Olewinski, M."],["dc.contributor.author","Boese, Alexandra"],["dc.contributor.author","Edelmann, F."],["dc.contributor.author","Meyer, T."],["dc.contributor.author","Wachter, R. Rolf"],["dc.date.accessioned","2018-11-07T09:39:39Z"],["dc.date.available","2018-11-07T09:39:39Z"],["dc.date.issued","2014"],["dc.format.extent","504"],["dc.identifier.doi","10.1016/j.jpsychores.2014.03.047"],["dc.identifier.isi","000336639300045"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33331"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.issn","1879-1360"],["dc.relation.issn","0022-3999"],["dc.title","Subjective well-being and hypertension: Effects of diagnostic labelling, antihypertensive medication and actual blood pressure"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","88"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Structure"],["dc.bibliographiccitation.lastpage","95"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Meyer, Tim"],["dc.contributor.author","de la Cruz, Xavier"],["dc.contributor.author","Orozco, Modesto"],["dc.date.accessioned","2022-06-08T11:11:36Z"],["dc.date.available","2022-06-08T11:11:36Z"],["dc.date.issued","2009-01-14"],["dc.description.abstract","Extended all-atom molecular dynamics simulations on all protein metafolds have been performed to obtain a complete picture of the gas phase proteome. The structural atlas of the gas phase proteome obtained here shows an unexpected maintenance of the global and local structure and of the general deformability pattern upon transfer to the gas phase under electrospray conditions. Despite a general compression, the solution structure can be easily very well recognized from the gas phase one, and most structural details, such as secondary structure, are well preserved upon vaporization. Rehydration of the gas phase protein leads in most cases to a very fast transition from gas phase to solution structure. Overall, our massive analysis (over 4 micros in solution and over 12 micros in the gas phase) demonstrates that solution-like structures can be determined by using mass spectroscopy and related techniques to obtain fast approximations to the solution structure."],["dc.identifier.doi","10.1016/j.str.2008.11.006"],["dc.identifier.pmid","19141285"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/111137"],["dc.language.iso","en"],["dc.relation.issn","0969-2126"],["dc.title","An atomistic view to the gas phase proteome"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Umbach, Nadine"],["dc.contributor.author","Freckmann, Luca"],["dc.contributor.author","Knopp, Cornelius"],["dc.contributor.author","Meyer, Tim"],["dc.contributor.author","Suhr, Markus"],["dc.contributor.author","Kusch, Harald"],["dc.creator.author","Harald Kusch"],["dc.creator.author","Tim Meyer"],["dc.creator.author","Nadine Umbach"],["dc.creator.author","Luca Freckmann"],["dc.creator.author","Cornelius Knopp"],["dc.creator.author","Markus Suhr"],["dc.date.accessioned","2019-10-16T07:34:34Z"],["dc.date.available","2019-10-16T07:34:34Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3205/18gmds098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62499"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/224"],["dc.language.iso","en"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | INF: Unterstützung der SFB 1002 Forschungsdatenintegration, -visualisierung und -nachnutzung"],["dc.relation.conference","63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS)"],["dc.relation.eventend","2018"],["dc.relation.eventlocation","Osnabrück"],["dc.relation.eventstart","2018"],["dc.relation.workinggroup","RG Nußbeck"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.title","From seamless acquisition and sustainable management to publication of next-generation sequencing data"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Zeitschrift für psychosomatische Medizin und Psychotherapie"],["dc.bibliographiccitation.lastpage","52"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Bruening, C."],["dc.contributor.author","Kleiber, C."],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Meyer, T."],["dc.date.accessioned","2018-11-07T10:03:27Z"],["dc.date.available","2018-11-07T10:03:27Z"],["dc.date.issued","2015"],["dc.identifier.isi","000352041500015"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38467"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Vandenhoeck & Ruprecht"],["dc.publisher.place","Gottingen"],["dc.relation.issn","1438-3608"],["dc.title","Reduced Quality of Life, Behavior Problems and Lipid Levels in Children and Adolescents Aged from 11-17 Years"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]