Männer, Jörg

[["dc.bibliographiccitation.artnumber","2959"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Demal, Till Joscha"],["dc.contributor.author","Heise, Melina"],["dc.contributor.author","Reiz, Benedikt"],["dc.contributor.author","Dogra, Deepika"],["dc.contributor.author","Brænne, Ingrid"],["dc.contributor.author","Reichenspurner, Hermann"],["dc.contributor.author","Männer, Jörg"],["dc.contributor.author","Aherrahrou, Zouhair"],["dc.contributor.author","Schunkert, Heribert"],["dc.contributor.author","Erdmann, Jeanette"],["dc.contributor.author","Abdelilah-Seyfried, Salim"],["dc.date.accessioned","2019-07-09T11:50:35Z"],["dc.date.available","2019-07-09T11:50:35Z"],["dc.date.issued","2019"],["dc.description.abstract","The genetics of many congenital heart diseases (CHDs) can only unsatisfactorily be explained by known chromosomal or Mendelian syndromes. Here, we present sequencing data of a family with a potentially multigenic origin of CHD. Twelve of nineteen family members carry a familial mutation [NM_004329.2:c.1328 G > A (p.R443H)] which encodes a predicted deleterious variant of BMPR1A. This mutation co-segregates with a linkage region on chromosome 1 that associates with the emergence of severe CHDs including Ebstein's anomaly, atrioventricular septal defect, and others. We show that the continuous overexpression of the zebrafish homologous mutation bmpr1aap.R438H within endocardium causes a reduced AV valve area, a downregulation of Wnt/ß-catenin signalling at the AV canal, and growth of additional tissue mass in adult zebrafish hearts. This finding opens the possibility of testing genetic interactions between BMPR1A and other candidate genes within linkage region 1 which may provide a first step towards unravelling more complex genetic patterns in cardiovascular disease aetiology."],["dc.identifier.doi","10.1038/s41598-019-39648-7"],["dc.identifier.pmid","30814609"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15970"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59803"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1454"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","1463"],["dc.bibliographiccitation.volume","233"],["dc.contributor.author","Manner, J."],["dc.contributor.author","Schlueter, J."],["dc.contributor.author","Brand, T."],["dc.date.accessioned","2018-11-07T10:57:02Z"],["dc.date.available","2018-11-07T10:57:02Z"],["dc.date.issued","2005"],["dc.description.abstract","The proepicardium (PE) is a primarily extracardiac progenitor cell population that colonizes the embryonic heart and delivers the epicardium, the subepicardial and intramyocardial fibroblasts, and the coronary vessels. Recent data show that PE-derived cells additionally play important regulatory roles in myocardial development and possibly in the normal morphogenesis of the heart. Research on the latter topics profits from the fact that loss-of-PE-function can be experimentally induced in chick embryos. So far, two microsurgical techniques were used to produce such embryos: (1) blocking of PE cell transfer with pieces of the eggshell membrane, and (2) mechanical excision of PE. Both of these techniques, however, have their shortcomings. We have searched, therefore, for new techniques to eliminate the PE. Here, we show that loss-of-PE-function can be induced by photoablation of the PE. Chick embryos were treated in ovo by means of a window in the eggshell at Hamburger and Hamilton (HH) stage 16 (iday 3). The pericardial coelom was opened, and the PE was externally stained with a 1% solution of Rose Bengal by means of a micropipette. Photoactivation of the dye was accomplished by illumination of the operation field with visible light. Examination on postoperative day 1 (iday 4, HH stages 19/20) disclosed complete removal of PE in every experimental embryo. On iday 9 (HH stages 33/34), the survival rate of experimental embryos was 35.7% (15 of 42). Development of the PE-derivatives was compromised in the heart of every survivor. The abnormalities encompassed hydro- or hemopericardium, epicardium-free areas with aneurysmatic outward bulging of the ventricular wall, thin myocardium, defects of the coronary vasculature, and abnormal tissue bridges between the ventricles and the pericardial wall. Our results show that photoablation of the PE is a powerful technique to induce long-lasting loss-of-PE-function in chick embryos. We have additionally obtained new data that suggest that the embryonic epicardium may make important contributions to the passive mechanics of the developing heart. (c) 2005 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/dvdy.20487"],["dc.identifier.isi","000230518000024"],["dc.identifier.pmid","15977171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50150"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1058-8388"],["dc.title","Experimental analyses of the function of the proepicardium using a new microsurgical procedure to induce loss-of-proepicardial-function in chick embryos"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","dev180091"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Development (Cambridge)"],["dc.bibliographiccitation.volume","146"],["dc.contributor.author","Lombardo, Verónica A."],["dc.contributor.author","Heise, Melina"],["dc.contributor.author","Moghtadaei, Motahareh"],["dc.contributor.author","Bornhorst, Dorothee"],["dc.contributor.author","Männer, Jörg"],["dc.contributor.author","Abdelilah-Seyfried, Salim"],["dc.date.accessioned","2020-04-03T13:50:24Z"],["dc.date.available","2020-04-03T13:50:24Z"],["dc.date.issued","2019-11-14"],["dc.description.abstract","Cardiac looping is an essential and highly conserved morphogenetic process that places the different regions of the developing vertebrate heart tube into proximity of their final topographical positions. High-resolution 4D live imaging of mosaically labelled cardiomyocytes reveals distinct cardiomyocyte behaviors that contribute to the deformation of the entire heart tube. Cardiomyocytes acquire a conical cell shape, which is most pronounced at the superior wall of the atrioventricular canal and contributes to S-shaped bending. Torsional deformation close to the outflow tract contributes to a torque-like winding of the entire heart tube between its two poles. Anisotropic growth of cardiomyocytes based on their positions reinforces S-shaping of the heart. During cardiac looping, bone morphogenetic protein pathway signaling is strongest at the future superior wall of the atrioventricular canal. Upon pharmacological or genetic inhibition of bone morphogenetic protein signaling, myocardial cells at the superior wall of the atrioventricular canal maintain cuboidal cell shapes and S-shaped bending is impaired. This description of cellular rearrangements and cardiac looping regulation may also be relevant for understanding the etiology of human congenital heart defects."],["dc.identifier.doi","10.1242/dev.180091"],["dc.identifier.pmid","31628109"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63643"],["dc.language.iso","en"],["dc.relation.eissn","1477-9129"],["dc.relation.issn","0950-1991"],["dc.relation.issn","1477-9129"],["dc.title","Morphogenetic control of zebrafish cardiac looping by Bmp signaling"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","425"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Annals of Anatomy - Anatomischer Anzeiger"],["dc.bibliographiccitation.lastpage","435"],["dc.bibliographiccitation.volume","193"],["dc.contributor.author","Happel, Christoph M."],["dc.contributor.author","Thrane, Lars"],["dc.contributor.author","Thommes, Jan"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T09:00:42Z"],["dc.date.available","2018-11-07T09:00:42Z"],["dc.date.issued","2011"],["dc.description.abstract","High-resolution in vivo imaging of higher vertebrate embryos over short or long time periods under constant physiological conditions is a technically challenging task for researchers working on cardiovascular development. In chick embryos, for example, various studies have shown that without appropriate maintenance of temperature, as one of the main environmental factors, the embryonic heart rate drops rapidly and often results in an increase in regurgitant flow. Hemodynamic parameters are critical stimuli for cardiovascular development that, for a correct evaluation of their developmental significance, should be documented under physiological conditions. However, previous studies were mostly carried out outside of an incubator or under suboptimal environmental conditions. Here we present, to the best of our knowledge, the first detailed description of an optical coherence tomography (OCT) system integrated into an examination incubator to facilitate real-time in vivo imaging of cardiovascular development under physiological environmental conditions. We demonstrate the suitability of this OCT examination incubator unit for use in cardiovascular development studies by examples of proof of principle experiments. We, furthermore, point out the need for use of examination incubators for physiological OCT examinations by documenting the effects of room climate (22 degrees C) on the performance of the cardiovascular system of chick embryos (HH-stages 16/17). Upon exposure to room climate, chick embryos showed a fast drop in the heart rate and striking changes in the cardiac contraction behaviour and the blood flow through the vitelline circulation. We have documented these changes for the first time by M-mode OCT and Doppler M-mode OCT. (C) 2011 Elsevier GmbH. All rights reserved."],["dc.identifier.doi","10.1016/j.aanat.2011.04.006"],["dc.identifier.isi","000296953300006"],["dc.identifier.pmid","21641190"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24236"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.relation.issn","0940-9602"],["dc.title","Integration of an optical coherence tomography (OCT) system into an examination incubator to facilitate in vivo imaging of cardiovascular development in higher vertebrate embryos under stable physiological conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","229"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Neurogenetics"],["dc.bibliographiccitation.lastpage","238"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Mannan, Ashraf U."],["dc.contributor.author","Roussa, Eleni"],["dc.contributor.author","Kraus, Cornelia"],["dc.contributor.author","Rickmann, Michael"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Nayernia, K."],["dc.contributor.author","Krieglstein, Kerstin"],["dc.contributor.author","Reis, A."],["dc.contributor.author","Engel, Wolfgang"],["dc.date.accessioned","2018-11-07T10:43:34Z"],["dc.date.available","2018-11-07T10:43:34Z"],["dc.date.issued","2004"],["dc.description.abstract","We report a novel spontaneous mutation named nax in mice, which exhibit delayed hair appearance and ataxia in a homozygote state. Histological analyses of nax brain revealed an overall impairment of the cerebellar cortex. The classical cortical cytoarchitecture was disrupted, the inner granule cell layer was not obvious, the Purkinje cells were not aligned as a Purkinje cell layer, and Bergmann glias did not span the molecular layer. Furthermore, histological analyses of skin showed that the hair follicles were also abnormal. We mapped the nax locus between marker D2Mit158 and D2Mit100 within a region of 800 kb in the middle of chromosome 2 and identified a missense mutation (Gly244Glu) in Acp2, a lysosomal monoesterase. The Glu244 mutation does not affect the stability of the Acp2 transcript, however it renders the enzyme inactive. Ultrastructural analysis of nax cerebellum showed lysosomal storage bodies in nucleated cells, suggesting progressive degeneration as the underlying mechanism. Identification of Acp2 as the gene mutated in nax mice provides a valuable model system for studying the role of Acp2 in cerebellum and skin homeostasis."],["dc.identifier.doi","10.1007/s10048-004-0197-9"],["dc.identifier.isi","000226285100005"],["dc.identifier.pmid","15503243"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47086"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1364-6745"],["dc.title","Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","joa.13720"],["dc.bibliographiccitation.journal","Journal of Anatomy"],["dc.contributor.author","Kakeya, Maki"],["dc.contributor.author","Matsubayashi, Jun"],["dc.contributor.author","Kanahashi, Toru"],["dc.contributor.author","Männer, Jörg"],["dc.contributor.author","Yamada, Shigehito"],["dc.contributor.author","Takakuwa, Tetsuya"],["dc.date.accessioned","2022-07-01T07:35:14Z"],["dc.date.available","2022-07-01T07:35:14Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1111/joa.13720"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112120"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.eissn","1469-7580"],["dc.relation.issn","0021-8782"],["dc.title","The return process of physiological umbilical herniation in human fetuses: The possible role of the vascular tree and umbilical ring"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Klinische Pädiatrie"],["dc.bibliographiccitation.volume","222"],["dc.contributor.author","Schaefer, Inga-Marie"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Faber, Renaldo"],["dc.contributor.author","Loertzer, Hagen"],["dc.contributor.author","Fuezesi, Laszlo"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Seeliger, Stefan"],["dc.date.accessioned","2018-11-07T08:42:52Z"],["dc.date.available","2018-11-07T08:42:52Z"],["dc.date.issued","2010"],["dc.format.extent","S104"],["dc.identifier.isi","000280523000339"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19809"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.issn","0300-8630"],["dc.title","A mature newborn with \"Giant umbilical cord.\""],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","385"],["dc.bibliographiccitation.lastpage","387"],["dc.bibliographiccitation.seriesnr","3552"],["dc.contributor.author","Fu, X. M."],["dc.contributor.author","Manner, J."],["dc.date.accessioned","2018-11-07T08:47:25Z"],["dc.date.available","2018-11-07T08:47:25Z"],["dc.date.issued","2005"],["dc.identifier.isi","000230383200040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20947"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Berlin"],["dc.relation.conference","13th International Workshop on Quality of Service (IWQoS 2005)"],["dc.relation.crisseries","Lecture Notes in Computer Science"],["dc.relation.eventend","2005-06-23"],["dc.relation.eventlocation","Passau, Germany"],["dc.relation.eventstart","2005-06-21"],["dc.relation.isbn","3-540-26294-6"],["dc.relation.ispartof","Quality of service - IWQoS 2005, Proceedings"],["dc.relation.ispartofseries","Lecture notes in computer science; 3552"],["dc.title","RSVP standards today and the path towards a generic messenger"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Happel, C. M."],["dc.contributor.author","Thommes, Jan"],["dc.contributor.author","Thrane, Lars"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Ortmaier, Tobias"],["dc.contributor.author","Heimann, B."],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T08:52:34Z"],["dc.date.available","2018-11-07T08:52:34Z"],["dc.date.issued","2011"],["dc.format.extent","834"],["dc.identifier.isi","000294690900061"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Rotationally acquired 4D optical coherence tomography (OCT) of embryonic chick hearts using retrospective gating on the common central A-scan"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3273"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","3284"],["dc.bibliographiccitation.volume","238"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Thrane, Lars"],["dc.contributor.author","Norozi, Kambiz"],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T11:21:24Z"],["dc.date.available","2018-11-07T11:21:24Z"],["dc.date.issued","2009"],["dc.description.abstract","The cardiac cycle-related deformations of tubular embryonic hearts were traditionally described as concentric narrowing and widening of a tube of circular cross-section. Using optical coherence tomography (OCT), we have recently shown that, during the cardiac cycle, only the myocardial tube undergoes concentric narrowing and widening while the endocardial tube undergoes eccentric narrowing and widening, having an elliptic cross-section at end-diastole and a slit-shaped cross-section at end-systole. Due to technical limitations, these analyses were confined to early stages of ventricular development (chick embryos, stages 10-13). Using a modified OCT-system, we now document, for the first time, the cyclic changes in cross-sectional shape of beating embryonic ventricles at stages 14 to 17. We show that during these stages (1) a large area of diminished cardiac jelly appears at the outer curvature of the ventricular region associated with formation of endocardial pouches; (2) the ventricular endocardial lumen acquires a bell-shaped cross-section at end-diastole and becomes compressed like a fireplace bellows during systole; (3) the contracting portions of the embryonic ventricles display stretching along its baso-apical axis at end-systole. The functional significance of our data is discussed with respect to early cardiac pumping function. Developmental Dynamics 238:3273-3284, 2009. (C) 2009 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/dvdy.22159"],["dc.identifier.isi","000272549100028"],["dc.identifier.pmid","19924823"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55763"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1058-8388"],["dc.title","In Vivo Imaging of the Cyclic Changes in Cross-sectional Shape of the Ventricular Segment of Pulsating Embryonic Chick Hearts at Stages 14 to 17: A Contribution to the Understanding of the Ontogenesis of Cardiac Pumping Function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]