Ulrich, Kathrin

[["dc.bibliographiccitation.firstpage","195"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.lastpage","235"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Hiemke, Christoph"],["dc.contributor.author","Baumann, P."],["dc.contributor.author","Bergemann, N."],["dc.contributor.author","Conca, A."],["dc.contributor.author","Dietmaier, O."],["dc.contributor.author","Egberts, K."],["dc.contributor.author","Fric, M."],["dc.contributor.author","Gerlach, M."],["dc.contributor.author","Greiner, C."],["dc.contributor.author","Gruender, Gerhard"],["dc.contributor.author","Haen, E."],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Sirot, E. Jaquenoud"],["dc.contributor.author","Kirchherr, H."],["dc.contributor.author","Laux, Gerd"],["dc.contributor.author","Lutz, U. C."],["dc.contributor.author","Messer, Thomas"],["dc.contributor.author","Mueller, M. J."],["dc.contributor.author","Pfuhlmann, B."],["dc.contributor.author","Rambeck, B."],["dc.contributor.author","Riederer, Peter"],["dc.contributor.author","Schoppek, B."],["dc.contributor.author","Stingl, Julia Carolin"],["dc.contributor.author","Uhr, Manfred"],["dc.contributor.author","Ulrich, S."],["dc.contributor.author","Waschgler, R."],["dc.contributor.author","Zernig, Gerald"],["dc.date.accessioned","2018-11-07T08:51:59Z"],["dc.date.available","2018-11-07T08:51:59Z"],["dc.date.issued","2011"],["dc.description.abstract","Therapeutic drug monitoring (TDM), i.e., the quantification of serum or plasma concentrations of medications for dose optimization, has proven a valuable tool for the patient-matched psychopharmacotherapy. Uncertain drug adherence, suboptimal tolerability, non-response at therapeutic doses, or pharmacokinetic drug-drug interactions are typical situations when measurement of medication concentrations is helpful. Patient populations that may predominantly benefit from TDM in psychiatry are children, pregnant women, elderly patients, individuals with intelligence disabilities, forensic patients, patients with known or suspected genetically determined pharmacokinetic abnormalities or individuals with pharmacokinetically relevant comorbidities. However, the potential benefits of TDM for optimization of pharmacotherapy can only be obtained if the method is adequately integrated into the clinical treatment process. To promote an appropriate use of TDM, the TDM expert group of the Arbeitsgemeinschaft fur Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) issued guidelines for TDM in psychiatry in 2004. Since then, knowledge has advanced significantly, and new psychopharmacologic agents have been introduced that are also candidates for TDM. Therefore the TDM consensus guidelines were updated and extended to 128 neuropsychiatric drugs. 4 levels of recommendation for using TDM were defined ranging from \"strongly recommended\" to \"potentially useful\". Evidence-based \"therapeutic reference ranges\" and \"dose related reference ranges\" were elaborated after an extensive literature search and a structured internal review process. A \"laboratory alert level\" was introduced, i.e., a plasma level at or above which the laboratory should immediately inform the treating physician. Supportive information such as cytochrome P450 substrate and inhibitor properties of medications, normal ranges of ratios of concentrations of drug metabolite to parent drug and recommendations for the interpretative services are given. Recommendations when to combine TDM with pharmacogenetic tests are also provided. Following the guidelines will help to improve the outcomes of psychopharmacotherapy of many patients especially in case of pharmacokinetic problems. Thereby, one should never forget that TDM is an interdisciplinary task that sometimes requires the respectful discussion of apparently discrepant data so that, ultimately, the patient can profit from such a joint effort."],["dc.identifier.doi","10.1055/s-0031-1286287"],["dc.identifier.isi","000296086300154"],["dc.identifier.pmid","21969060"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22062"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0176-3679"],["dc.title","AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Molecular Cell"],["dc.contributor.author","Ulrich, Kathrin"],["dc.contributor.author","Farkas, Ákos"],["dc.contributor.author","Chan, Olivia"],["dc.contributor.author","Katamanin, Olivia"],["dc.contributor.author","Schwappach, Blanche"],["dc.contributor.author","Jakob, Ursula"],["dc.date.accessioned","2022-09-01T09:49:44Z"],["dc.date.available","2022-09-01T09:49:44Z"],["dc.date.issued","2022"],["dc.description.sponsorship"," http://dx.doi.org/10.13039/501100001659 Deutsche Forschungsgemeinschaft"],["dc.description.sponsorship"," http://dx.doi.org/10.13039/100000002 National Institutes of Health"],["dc.identifier.doi","10.1016/j.molcel.2022.06.015"],["dc.identifier.pii","S1097276522005986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113516"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.issn","1097-2765"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","From guide to guard—activation mechanism of the stress-sensing chaperone Get3"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","557"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","566"],["dc.bibliographiccitation.volume","266"],["dc.contributor.author","Engel, K. R."],["dc.contributor.author","Obst, K."],["dc.contributor.author","Bandelow, B."],["dc.contributor.author","Dechent, P."],["dc.contributor.author","Gruber, O."],["dc.contributor.author","Zerr, I."],["dc.contributor.author","Ulrich, K."],["dc.contributor.author","Wedekind, D."],["dc.date.accessioned","2017-11-28T10:03:35Z"],["dc.date.available","2017-11-28T10:03:35Z"],["dc.date.issued","2015"],["dc.description.abstract","There is evidence that besides limbic brain structures, prefrontal and insular cortical activations and deactivations are involved in the pathophysiology of panic disorder. This study investigated activation response patterns to stimulation with individually selected panic-specific pictures in patients with panic disorder with agoraphobia (PDA) and healthy control subjects using functional magnetic resonance imaging (fMRI). Structures of interest were the prefrontal, cingulate, and insular cortex, and the amygdalo-hippocampal complex. Nineteen PDA subjects (10 females, 9 males) and 21 healthy matched controls were investigated using a Siemens 3-Tesla scanner. First, PDA subjects gave Self-Assessment Manikin (SAM) ratings on 120 pictures showing characteristic panic/agoraphobia situations, of which 20 pictures with the individually highest SAM ratings were selected. Twenty matched pictures showing aversive but not panic-specific stimuli and 80 neutral pictures from the International Affective Picture System were chosen for each subject as controls. Each picture was shown twice in each of four subsequent blocks. Anxiety and depression ratings were recorded before and after the experiment. Group comparisons revealed a significantly greater activation in PDA patients than control subjects in the insular cortices, left inferior frontal gyrus, dorsomedial prefrontal cortex, the left hippocampal formation, and left caudatum, when PA and N responses were compared. Comparisons for stimulation with unspecific aversive pictures showed activation of similar brain regions in both groups. Results indicate region-specific activations to panic-specific picture stimulation in PDA patients. They also imply dysfunctionality in the processing of interoceptive cues in PDA and the regulation of negative emotionality. Therefore, differences in the functional networks between PDA patients and control subjects should be further investigated."],["dc.identifier.doi","10.1007/s00406-015-0653-6"],["dc.identifier.fs","624606"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/10614"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1433-8491"],["dc.relation.issn","0940-1334"],["dc.title","Functional MRI activation in response to panic-specific, non-panic aversive, and neutral pictures in patients with panic disorder and healthy controls"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","unknown"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","239"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biological Chemistry"],["dc.bibliographiccitation.lastpage","252"],["dc.bibliographiccitation.volume","402"],["dc.contributor.author","Ulrich, Kathrin"],["dc.contributor.author","Schwappach, Blanche"],["dc.contributor.author","Jakob, Ursula"],["dc.date.accessioned","2021-04-14T08:28:03Z"],["dc.date.available","2021-04-14T08:28:03Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1515/hsz-2020-0262"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82489"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1437-4315"],["dc.relation.issn","1431-6730"],["dc.title","Thiol-based switching mechanisms of stress-sensing chaperones"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","HOMO"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Ruhli, F. J."],["dc.contributor.author","Lanz, C."],["dc.contributor.author","Ulrich, S."],["dc.contributor.author","Hesse, H."],["dc.contributor.author","Schultz, M."],["dc.contributor.author","von Smekal, A."],["dc.date.accessioned","2018-11-07T11:06:47Z"],["dc.date.available","2018-11-07T11:06:47Z"],["dc.date.issued","2000"],["dc.format.extent","S105"],["dc.identifier.isi","000089900400107"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52397"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.issn","0018-442X"],["dc.title","Comparative morphology and bone diseases in multislice CT scans and in histology"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","677"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","EPL"],["dc.bibliographiccitation.lastpage","682"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Ulrich, S."],["dc.contributor.author","Mao, Xiaoming"],["dc.contributor.author","Goldbart, Paul M."],["dc.contributor.author","Zippelius, Annette"],["dc.date.accessioned","2018-11-07T09:00:44Z"],["dc.date.available","2018-11-07T09:00:44Z"],["dc.date.issued","2006"],["dc.description.abstract","Starting from a microscopic model of randomly cross-linked particles with quenched disorder, we calculate the Landau-Wilson free energy S for arbitrary cross-link densities. Considering pure shear deformations, S takes the form of the elastic energy of an isotropic amorphous solid state, from which the shear modulus can be identified. It is found to be a universal quantity, not depending on any microscopic length-scales of the model."],["dc.identifier.doi","10.1209/epl/i2006-10310-7"],["dc.identifier.isi","000242210900021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24246"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Edp Sciences S A"],["dc.relation.issn","0295-5075"],["dc.title","Elasticity of highly cross-linked random networks"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]