Großkopf, Birgit

[["dc.bibliographiccitation.artnumber","8"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Biological Research-Thessaloniki"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Sarocka, Anna"],["dc.contributor.author","Babosova, Ramona"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Kapusta, Edyta"],["dc.contributor.author","Goc, Zofia"],["dc.contributor.author","Formicki, Grzegorz"],["dc.contributor.author","Omelka, Radoslav"],["dc.date.accessioned","2019-07-09T11:45:30Z"],["dc.date.available","2019-07-09T11:45:30Z"],["dc.date.issued","2018"],["dc.description.abstract","Background: Alcohol is one of the most commonly consumed neurotoxins by humans. Its negative effect on bone health is known for a long time. However, its impact on qualitative and quantitative 2D characteristics of the compact bone is still unclear. Therefore, the aim of this study was to investigate in detail the effects of subchronic alcohol exposure on compact and trabecular bone tissues microstructure of laboratory mice using 2D and 3D imaging methods. Ten clinically healthy 12 weeks-old mice (males) were randomly divided into two groups. Animals from experimental group (group E; n = 5) drank a solution composed of 15% ethanol and water (1.7 g 100% ethanol kg-1 b.w. per day) for 8 weeks, while those from control group (group C; n = 5) drank only water. Results: Subchronic exposure to alcohol leads to several changes in qualitative 2D characteristics of the compact bone such as the presence of primary vascular radial bone tissue in pars anterior of endosteal border and a higher number of resorption lacunae (five times more) in the middle part of substantia compacta. Morphometrical 2D evaluations of the compact bone showed significantly increased sizes of primary osteons' vascular canals (p < 0.05) in mice from the experimental group (E group). Sizes of Haversian canals and secondary osteons were not affected by alcohol consumption. In mice from the E group, significantly lower values for relative bone volume and bone mineral density of the compact bone were observed. In the trabecular bone, decreased values for bone volume, trabecular number, trabecular thickness and bone surface (p < 0.05) were documented. Conclusions: Alcohol decreased not only bone volume and density of the compact bone, but it also reduced trabecular bone volume and leads to trabecular thinning. It caused vasodilation of primary osteons' vascular canals and increased porosity in the compact bone."],["dc.identifier.doi","10.1186/s40709-018-0079-1"],["dc.identifier.pmid","29876325"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59242"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Changes in the microstructure of compact and trabecular bone tissues of mice subchronically exposed to alcohol"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Anthropologischer Anzeiger"],["dc.bibliographiccitation.lastpage","19"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Grosskopf, Birgit"],["dc.date.accessioned","2021-06-01T09:42:06Z"],["dc.date.available","2021-06-01T09:42:06Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1127/anthranz/2020/1249"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85145"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0003-5548"],["dc.title","Cremations, more than just a little pile of ash"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","206"],["dc.bibliographiccitation.journal","Osteoporosis International"],["dc.bibliographiccitation.lastpage","207"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Chovancova, Hana"],["dc.contributor.author","Pavlova, S."],["dc.contributor.author","Toman, Robert"],["dc.date.accessioned","2018-11-07T08:43:46Z"],["dc.date.available","2018-11-07T08:43:46Z"],["dc.date.issued","2010"],["dc.identifier.isi","000277299400446"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20053"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","London"],["dc.relation.conference","IOF World Congress on Osteoporosis/10th European Congress on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis"],["dc.relation.eventlocation","Florence, ITALY"],["dc.relation.issn","0937-941X"],["dc.title","CHANGES IN FEMORAL BONE STRUCTURE OF RATS AFTER AN INTRAPERITONEAL ADMINISTRATION OF CADMIUM"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","38"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Pharmacology and Toxicology"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Sarocka, Anna"],["dc.contributor.author","Kovacova, Veronika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Kapusta, Edyta"],["dc.contributor.author","Goc, Zofia"],["dc.contributor.author","Formicki, Grzegorz"],["dc.contributor.author","Martiniakova, Monika"],["dc.date.accessioned","2019-07-09T11:51:58Z"],["dc.date.available","2019-07-09T11:51:58Z"],["dc.date.issued","2019"],["dc.description.abstract","Abstract Background This study aimed to examine femoral bone microstructure of mice after single and simultaneous administration to acrylamide and ethanol since both substances are often consumed separately and/or together by humans. Interactive effects of these toxins were analysed after one remodeling cycle. Methods Twenty clinically healthy adult mice were randomly divided into four groups following 2 weeks administration of toxins: A group - mice were fed with acrylamide (40 mg/kg bw); E group - mice were ethanol-fed (15% ethanol); AE group - mice were simultaneously fed with both toxins, and a C group – control (without acrylamide and/or ethanol supplementation). Generally, 2D and 3D imaging methods were used to determine cortical and trabecular bone tissues microstructure. Biochemical analyses of plasma parameters were also realized using commercially available ELISA tests and spectrophotometrically. Results Single and simultaneous exposure to acrylamide and ethanol affected only cortical bone microstructure. No significant changes in trabecular bone morphometry were detected among all groups. In mice from the A group, increased endocortical remodeling associated with a higher level of serum calcium and vasoconstriction of primary osteon’s vascular canals (POVC) were identified. On the contrary, increased cortical porosity consistent with a decreased relative bone volume, bone mineral density (BMD) and lower levels of alkaline phosphatase (ALP), glutathione (GSH), calcium in plasma and also with vasodilation of POVC were observed in the E group. In the AE group, the highest density of secondary osteons associated with a lower BMD and decreased levels of ALP, GSH were documented. The parameters of POVC and Haversian canals approximated to the C group. In addition, single and simultaneous exposure to both toxins caused liver disease consistent with a higher values of alanine aminotransferase (ALT), aspartate aminotransferase (AST) in plasma of all experimental groups. Conclusions Single administration to acrylamide and ethanol had negative effects on cortical bone structure of mice after one remodeling cycle. However, we identified possible antagonistic impact of these toxins on the structure of the cortical bone."],["dc.identifier.doi","10.1186/s40360-019-0317-7"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16252"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60055"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Single and simultaneous effects of acrylamide and ethanol on bone microstructure of mice after one remodeling cycle"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S179"],["dc.bibliographiccitation.journal","Osteoporosis International"],["dc.bibliographiccitation.lastpage","S180"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Vondrakova, Maria"],["dc.contributor.author","Bauerova, Maria"],["dc.date.accessioned","2018-11-07T09:55:28Z"],["dc.date.available","2018-11-07T09:55:28Z"],["dc.date.issued","2006"],["dc.identifier.isi","000245980600155"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36746"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Artington"],["dc.relation.eventlocation","Washington, DC"],["dc.relation.issn","0937-941X"],["dc.title","Prevalence of femoral osteoporosis in medieval humans from Dubovany cemetery (Western Slovakia): Macroscopic and microscopic examination"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","109"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Environmental Science and Health, Part B"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Kovacova, Veronika"],["dc.contributor.author","Mondockova, Vladimira"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Kolesarova, Adriana"],["dc.contributor.author","Martiniakova, Monika"],["dc.date.accessioned","2021-04-14T08:30:13Z"],["dc.date.available","2021-04-14T08:30:13Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1080/03601234.2020.1852054"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83151"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1532-4109"],["dc.relation.issn","0360-1234"],["dc.title","Cyanogenic glycoside amygdalin influences functions of human osteoblasts in vitro"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Acta veterinaria Scandinavica"],["dc.bibliographiccitation.lastpage","6"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Martiniaková, Monika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Sirotkin, Alexander V."],["dc.contributor.author","Chrenek, Peter"],["dc.date.accessioned","2019-07-10T08:12:57Z"],["dc.date.available","2019-07-10T08:12:57Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: While gross morphological changes in the skeleton between males and females are well know, differences between sexes in the histomorphology are less known. It is important to have knowledge on the bone structure of rabbits, as this is a widely used species in biomedical research. A study was performed to evaluate the association between sex and the compact bone morphology of the femoral diaphysis in juvenile rabbits.Methods:Seventeen clinically healthy 23 month-old rabbits (9 females, 8 males) were included in the study. The rabbits were euthanized and the right femur was sampled for analysis. 7080 microns thick bone sections of the femoral diaphysis were prepared using standard histological equipment. The qualitative histological characteristics were determined according to internationally accepted classification systems while the quantitative parameters were assessed using the software Scion Image. Areas, perimeters, minimum and maximum diameters of primary osteons' vascular canals, Haversian canals and secondary osteons were measured. Additionally, blood plasma concentrations of progesterone, corticosterone, IGF-I, testosterone and estradiol were analyzed.Results: Qualitative histological characteristics were similar for both sexes. However, variations of certain quantitative histological characteristics were identified. Measured parameters of the primary osteons' vascular canals were higher in males than for females. On the other hand, females had significant higher values of secondary osteons parameters. Differences in Haversian canals parameters were only significant for minimum diameter. Conclusion: The study demonstrated that quantitative histological characteristics of compact bone tissue of the femoral diaphysis in juvenile rabbits were sex dependent. The variations may be associated with different growth and modeling of the femur through influence by sex-specific steroids, mechanical loads, genetic factors and a multitude of other sources. The results can be applied in experimental studies focusing on comparison of the skeletal biology of the sexes."],["dc.identifier.fs","492195"],["dc.identifier.ppn","57562440X"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4339"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61084"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1751-0147"],["dc.relation.orgunit","Fakultät für Biologie und Psychologie"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","590"],["dc.title","Sex-related variation in compact bone microstructure of the femoral diaphysis in juvenile rabbits"],["dc.title.alternative","Research"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","43"],["dc.bibliographiccitation.journal","ACTA VETERINARIA SCANDINAVICA"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Babosova, Ramona"],["dc.contributor.author","Duranova, Hana"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Kovacova, Veronika"],["dc.contributor.author","Adamkovicova, Maria"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Capcarova, Marcela"],["dc.contributor.author","Martiniakova, Monika"],["dc.date.accessioned","2018-11-07T10:12:34Z"],["dc.date.available","2018-11-07T10:12:34Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Quercetin is one of the best known flavonoids being present in a variety of fruits and vegetables. It has cardioprotective, anticarcinogenic, antioxidant, anti-inflammatory and antiapoptotic properties. Some studies suggest that quercetin has protective effects on bone. However, its influence on qualitative and quantitative histological characteristics of compact bone is still unknown. In our study, 12 clinically healthy five-month-old female rabbits were divided into four groups of three animals each. Quercetin was applied intramuscularly in various concentrations; 10 mu g/kg body weight (bw) in the E1 group, 100 mu g/kg bw in the E2 group, and 1000 mu g/kg bw in the E3 group for 90 days, 3 times per week. Three rabbits without exposure to quercetin served as a control (C) group. Differences in femoral bone microstructure among groups were evaluated. Results: Qualitative histological characteristics of compact bone differed between rabbits from the E1 and E2 groups. Primary vascular longitudinal bone tissue was not found in some areas near the endosteal surface due to increased endocortical bone resorption. In addition, periosteal border of rabbits from the E1 group was composed of a thicker layer of primary vascular longitudinal bone tissue than in the other groups. In all groups of rabbits administered quercetin, a lower density of secondary osteons was observed. Histomorphometrical evaluations showed significantly decreased sizes of the primary osteons' vascular canals in individuals from the E1 and E2 groups. Secondary osteons were significantly smaller in rabbits from the E1, E2, E3 groups when compared to the C group. Cortical bone thickness was significantly increased in females from the E1 and E2 groups. Conclusions: The results indicate that quercetin has not only a positive dose-response on qualitative and quantitative histological characteristics of the compact bone of female rabbits as it would be expected."],["dc.identifier.doi","10.1186/s13028-016-0225-4"],["dc.identifier.isi","000379248600001"],["dc.identifier.pmid","27357122"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13383"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40262"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1751-0147"],["dc.relation.issn","0044-605X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Structural changes in femoral bone microstructure of female rabbits after intramuscular administration of quercetin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","58"],["dc.bibliographiccitation.journal","ACTA VETERINARIA SCANDINAVICA"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Jancova, Alena"],["dc.date.accessioned","2018-11-07T08:37:02Z"],["dc.date.available","2018-11-07T08:37:02Z"],["dc.date.issued","2010"],["dc.description.abstract","Background: Free-living wild rodents are often used as zoomonitors of environmental contamination. In the present study, accumulation of cadmium (Cd), copper (Cu), iron (Fe), and zinc (Zn) in critical organs of yellow-necked mice (Apodemus flavicollis) and bank voles (Myodes glareolus) trapped in a polluted area in Novaky, Slovakia was investigated. Methods: Yellow-necked mice (n = 8) and bank voles (n = 10) were collected using standard theriological methods for wood ecosystems. All animals were adult males in good physical condition. The concentrations of Cd, Cu, Fe, and Zn in the liver, kidney, and bone were determined by atomic absorption spectrophotometry. Results: The highest concentrations of Cd and Zn were found in the bone of both species while Cu and Fe accumulated mainly in kidney or liver. Significant higher concentrations of Cd and Cu were detected in the liver of bank voles than in yellow-necked mice. Similar significant higher levels of Cd and Zn were found in the bone of bank voles. In contrast, significant higher concentrations of Cu and Fe were present in the kidney of yellow-necked mice. Conclusions: In the yellow-necked mouse and bank vole, bone seems to accumulate Cd and Zn following prolonged exposure. On the contrary, kidney and liver store Cu and Fe after a long-term environmental exposure. In the present study, bank voles seemed to be more heavy metal loaded zoomonitors than yellow-necked mice."],["dc.description.sponsorship","Ministry of Education, Slovakia [KEGA 3/7338/09]"],["dc.identifier.doi","10.1186/1751-0147-52-58"],["dc.identifier.isi","284276100001"],["dc.identifier.pmid","21054852"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5725"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18439"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","0044-605X"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Yellow-necked mice (Apodemus flavicollis) and bank voles (Myodes glareolus) as zoomonitors of environmental contamination at a polluted area in Slovakia"],["dc.title.original","5725"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","53"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Anthropologie"],["dc.bibliographiccitation.lastpage","67"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","GROSSKOPF, Birgit"],["dc.contributor.author","Rieger, ANNA-KATHARINA"],["dc.date.accessioned","2020-12-10T18:43:53Z"],["dc.date.available","2020-12-10T18:43:53Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.26720/anthro"],["dc.identifier.eissn","2570-9127"],["dc.identifier.issn","0323-1119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78257"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","BURIED IN THE VILLAGE: SKELETON FINDS IN A GRAECO-ROMAN SETTLEMENT AT WADI UMM EL-ASHDAN, NW-EGYPT"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]