Wettwer, Erich

[["dc.bibliographiccitation.firstpage","426"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cardiovascular Research"],["dc.bibliographiccitation.lastpage","437"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Voigt, Niels"],["dc.contributor.author","FRIEDRICH, A"],["dc.contributor.author","BOCK, M"],["dc.contributor.author","WETTWER, E"],["dc.contributor.author","CHRIST, T"],["dc.contributor.author","KNAUT, M"],["dc.contributor.author","STRASSER, R"],["dc.contributor.author","RAVENS, U"],["dc.contributor.author","DOBREV, D"],["dc.date.accessioned","2022-03-01T11:45:02Z"],["dc.date.available","2022-03-01T11:45:02Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1016/j.cardiores.2007.02.009"],["dc.identifier.pii","S0008636307000594"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103191"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0008-6363"],["dc.title","Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Acta Physiologica"],["dc.bibliographiccitation.volume","216"],["dc.contributor.author","Thieleczek, R."],["dc.contributor.author","Liao, M.-L. Chang"],["dc.contributor.author","Zimmermann, H.-W."],["dc.contributor.author","Wettwer, E."],["dc.date.accessioned","2018-11-07T10:17:30Z"],["dc.date.available","2018-11-07T10:17:30Z"],["dc.date.issued","2016"],["dc.identifier.isi","000372285400472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41239"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1748-1716"],["dc.relation.issn","1748-1708"],["dc.title","Automated Cardiac Action Potential Analysis (CAPA)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","263"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Medical & Biological Engineering & Computing"],["dc.bibliographiccitation.lastpage","273"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Ravens, Ursula"],["dc.contributor.author","Katircioglu-Öztürk, Deniz"],["dc.contributor.author","Wettwer, Erich"],["dc.contributor.author","Christ, Torsten"],["dc.contributor.author","Dobrev, Dobromir"],["dc.contributor.author","Voigt, Niels"],["dc.contributor.author","Poulet, Claire"],["dc.contributor.author","Loose, Simone"],["dc.contributor.author","Simon, Jana"],["dc.contributor.author","Stein, Agnes"],["dc.contributor.author","Güvenir, H. Altay"],["dc.date.accessioned","2022-03-01T11:44:37Z"],["dc.date.available","2022-03-01T11:44:37Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1007/s11517-014-1232-0"],["dc.identifier.pii","1232"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103070"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1741-0444"],["dc.relation.issn","0140-0118"],["dc.rights.uri","http://www.springer.com/tdm"],["dc.title","Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","401"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","412"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Chang Liao, Mei-Ling"],["dc.contributor.author","Boer, Teun P. de"],["dc.contributor.author","Mutoh, Hiroki"],["dc.contributor.author","Raad, Nour"],["dc.contributor.author","Richter, Claudia"],["dc.contributor.author","Wagner, Eva"],["dc.contributor.author","Downie, Bryan R."],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Arooj, Iqra"],["dc.contributor.author","Streckfuss-Boemeke, Katrin"],["dc.contributor.author","Doeker, Stephan"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Wagner, Stefan"],["dc.contributor.author","Lehnart, Stephan E."],["dc.contributor.author","Maier, Lars S."],["dc.contributor.author","Stühmer, Walter"],["dc.contributor.author","Wettwer, Erich"],["dc.contributor.author","van Veen, Toon"],["dc.contributor.author","Morlock, Michael M."],["dc.contributor.author","Knoepfel, Thomas"],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.date.accessioned","2017-09-07T11:43:37Z"],["dc.date.available","2017-09-07T11:43:37Z"],["dc.date.issued","2015"],["dc.description.abstract","Rationale: Monitoring and controlling cardiac myocyte activity with optogenetic tools offer exciting possibilities for fundamental and translational cardiovascular research. Genetically encoded voltage indicators may be particularly attractive for minimal invasive and repeated assessments of cardiac excitation from the cellular to the whole heart level. Objective: To test the hypothesis that cardiac myocyte-targeted voltage-sensitive fluorescence protein 2.3 (VSFP2.3) can be exploited as optogenetic tool for the monitoring of electric activity in isolated cardiac myocytes and the whole heart as well as function and maturity in induced pluripotent stem cell-derived cardiac myocytes. Methods and Results: We first generated mice with cardiac myocyte-restricted expression of VSFP2.3 and demonstrated distinct localization of VSFP2.3 at the t-tubulus/junctional sarcoplasmic reticulum microdomain without any signs for associated pathologies (assessed by echocardiography, RNA-sequencing, and patch clamping). Optically recorded VSFP2.3 signals correlated well with membrane voltage measured simultaneously by patch clamping. The use of VSFP2.3 for human action potential recordings was confirmed by simulation of immature and mature action potentials in murine VSFP2.3 cardiac myocytes. Optical cardiograms could be monitored in whole hearts ex vivo and minimally invasively in vivo via fiber optics at physiological heart rate (10 Hz) and under pacing-induced arrhythmia. Finally, we reprogrammed tail-tip fibroblasts from transgenic mice and used the VSFP2.3 sensor for benchmarking functional and structural maturation in induced pluripotent stem cell-derived cardiac myocytes. Conclusions: We introduce a novel transgenic voltage-sensor model as a new method in cardiovascular research and provide proof of concept for its use in optogenetic sensing of physiological and pathological excitation in mature and immature cardiac myocytes in vitro and in vivo."],["dc.identifier.doi","10.1161/CIRCRESAHA.117.306143"],["dc.identifier.gro","3141844"],["dc.identifier.isi","000359658700005"],["dc.identifier.pmid","26078285"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1701"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/84"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A03: Bedeutung CaMKII-abhängiger Mechanismen für die Arrhythmogenese bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A04: Patienten-spezifische induzierte pluripotente Stammzellen zur funktionellen Untersuchung von Ryanodinrezeptor-Mutationen"],["dc.relation","SFB 1002 | A05: Molekulares Imaging von kardialen Calcium-Freisetzungsdomänen"],["dc.relation","SFB 1002 | A09: Lokale molekulare Nanodomänen-Regulation der kardialen Ryanodin-Rezeptor-Funktion"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation","SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation.eissn","1524-4571"],["dc.relation.issn","0009-7330"],["dc.relation.workinggroup","RG Guan (Application of patient-specific induced pluripotent stem cells in disease modelling)"],["dc.relation.workinggroup","RG Lehnart (Cellular Biophysics and Translational Cardiology Section)"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.relation.workinggroup","RG L. Maier (Experimentelle Kardiologie)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.title","Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","251"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg's Archives of Pharmacology"],["dc.bibliographiccitation.lastpage","259"],["dc.bibliographiccitation.volume","381"],["dc.contributor.author","Voigt, Niels"],["dc.contributor.author","Rozmaritsa, Nadiia"],["dc.contributor.author","Trausch, Anne"],["dc.contributor.author","Zimniak, Thomasz"],["dc.contributor.author","Christ, Torsten"],["dc.contributor.author","Wettwer, Erich"],["dc.contributor.author","Matschke, Klaus"],["dc.contributor.author","Dobrev, Dobromir"],["dc.contributor.author","Ravens, Ursula"],["dc.date.accessioned","2022-03-01T11:44:24Z"],["dc.date.available","2022-03-01T11:44:24Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1007/s00210-009-0452-6"],["dc.identifier.pii","452"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103019"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1432-1912"],["dc.relation.issn","0028-1298"],["dc.title","Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]