Kramer, Katharina

[["dc.bibliographiccitation.firstpage","189"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Alzheimer s Disease"],["dc.bibliographiccitation.lastpage","196"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Schmidt, Christian D."],["dc.contributor.author","Gerlach, Nicole"],["dc.contributor.author","Schmitz, Matthias"],["dc.contributor.author","Thom, Tobias"],["dc.contributor.author","Kramer, Katharina"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Zerr, Inga"],["dc.date.accessioned","2018-11-07T10:02:58Z"],["dc.date.available","2018-11-07T10:02:58Z"],["dc.date.issued","2015"],["dc.description.abstract","Background/Objective: Apolipoprotein E (ApoE) has an active part in the pathogenesis of Alzheimer's disease (AD). Cerebrospinal fluid (CSF) and plasma level alterations have been reported in AD patients. In search of a biomarker potentially predictive of cognitive, functional, or motor decline, we analyzed the CSF to serum ratios of ApoE levels (CSF/serum ApoE) in AD patients in this regard. Methods: Subjects with newly diagnosed AD were followed within a longitudinal observational study (rpAD study). Annual neuropsychological testing and physical examination were performed. Multiple regression analyses were used to determine possible associations of the ApoE CSF/serum concentration ratios and velocity of decline on a variety of cognitive, functional and motor scales (MMSE, iADL, bADL, GDS, UPDRSIII) adjusted for relevant co-variables. Results: CSF/serum ratios of ApoE levels were associated with progression on the UPDRSIII (change of UPDRSIII slope [pt/yr] per unit of ApoE CSF/serum = -0.06, p < 0.01) and instrumental ADL scale (change of iADL slope [pt/yr] per unit of ApoE CSF/serum = 0.01, p = 0.01) (\"the lower the ratio, the faster the deterioration\" and vice versa). Secondarily, higher age at onset was associated with faster UPDRSIII progression, antidepressant use with faster iADL decline, and better baseline function with more rapid decline on either MMSE, iADL, or GDS scale. Conclusion: Here, CSF/serum ApoE at time of AD diagnosis was shown to be inversely associated with medium-term functional and motor progression. Whether this ratio qualifies for the use as a predictive biomarker must be validated in larger cohort studies over the long term."],["dc.description.sponsorship","Bundesministerium fur Bildung und Forschung (BMBF) [01GI1010C, KNDD-2]"],["dc.identifier.doi","10.3233/JAD-150286"],["dc.identifier.isi","000360931700017"],["dc.identifier.pmid","26401939"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38342"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.relation.issn","1875-8908"],["dc.relation.issn","1387-2877"],["dc.title","Baseline CSF/Serum-Ratio of Apolipoprotein E and Rate of Differential Decline in Alzheimer's Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","11"],["dc.bibliographiccitation.artnumber","http://creativecommons.org/licenses/by/4.0/"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Diagnostic and Prognostic Research"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Gopalakrishna, Gowri"],["dc.contributor.author","Langendam, Miranda"],["dc.contributor.author","Scholten, Rob"],["dc.contributor.author","Bossuyt, Patrick"],["dc.contributor.author","Leeflang, Mariska"],["dc.contributor.author","Noel-Storr, Anna"],["dc.contributor.author","Thomas, James"],["dc.contributor.author","Marshall, Iain"],["dc.contributor.author","Wallace, Byron"],["dc.contributor.author","Whiting, Penny"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Kramer, Katharina"],["dc.date.accessioned","2017-03-31T06:02:21Z"],["dc.date.accessioned","2021-10-27T13:20:57Z"],["dc.date.available","2017-03-31T06:02:21Z"],["dc.date.available","2021-10-27T13:20:57Z"],["dc.date.issued","2017"],["dc.date.updated","2017-03-31T06:02:21Z"],["dc.identifier.doi","10.1186/s41512-017-0011-4"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14398"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91985"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.iserratumof","/handle/2/58838"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Erratum to: Methods for evaluating medical tests and biomarkers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","erratum_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","705"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Nature Structural & Molecular Biology"],["dc.bibliographiccitation.lastpage","713"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Lazzaretti, Daniela"],["dc.contributor.author","Veith, Katharina"],["dc.contributor.author","Kramer, Katharina"],["dc.contributor.author","Basquin, Claire"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Irion, Uwe"],["dc.contributor.author","Bono, Fulvia"],["dc.date.accessioned","2020-12-10T18:09:33Z"],["dc.date.available","2020-12-10T18:09:33Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1038/nsmb.3254"],["dc.identifier.eissn","1545-9985"],["dc.identifier.issn","1545-9993"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73692"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The bicoid mRNA localization factor Exuperantia is an RNA-binding pseudonuclease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","307"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","AMERICAN JOURNAL OF DENTISTRY"],["dc.bibliographiccitation.lastpage","314"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Schmickler, Jan"],["dc.contributor.author","Wurbs, Sabine"],["dc.contributor.author","Wurbs, Susanne"],["dc.contributor.author","Kramer, Katharina"],["dc.contributor.author","Rinke, Sven"],["dc.contributor.author","Hornecker, Else"],["dc.contributor.author","Mausberg, Rainer F."],["dc.contributor.author","Ziebolz, Dirk"],["dc.date.accessioned","2018-11-07T10:04:42Z"],["dc.date.available","2018-11-07T10:04:42Z"],["dc.date.issued","2016"],["dc.description.abstract","Purpose: This randomized clinical trial investigated the influence of the utilization time of brush heads from different types of power toothbrushes [oscillating rotating (OR) and sonic action (SA)] on oral hygiene (plaque accumulation and gingival inflammation) over a 6-month observation period. Methods: 49 participants were randomly allocated into two groups: use of the same brush head over 6 months (NR: non-replacement) or replacement of brush head every 4 weeks over 6 months (R: replacement). Each group was subdivided into two subgroups according to kind of toothbrush (TB) used (OR and SA). Modified Quigley-Hein plaque index (QHI), papilla bleeding index (PBI), and gingival index (GI) were recorded at baseline and 2, 8, 12, 16, and 24 weeks after baseline. After 24 weeks, participants of both groups (R and NR) received a new brush head. At week 26, final QHI, PBI, and GI were recorded. Results: QHI decreased between baseline and follow-up visits in R groups (P< 0.05), with the exception of week 12 (P= 0.26). In NR groups, no significant decrease was detected (P> 0.05). There was no significant effect of time on PBI or GI in any of R subgroups (P> 0.05). In NR oscillating/rotating TB: significant increase in PBI and GI was detected 24 weeks after baseline (PBI: P= 0.02, GI: P= 0.03); sonic action TBs showed significant decrease in PBI at every follow-up visit (P< 0.05), except at 24 weeks after baseline (P= 0.73). GI was significantly decreased at 2 weeks after baseline only (P< 0.01)."],["dc.identifier.isi","000393846100002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38754"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosher & Linder, Inc"],["dc.relation.issn","0894-8275"],["dc.title","The influence of the utilization time of brush heads from different types of power toothbrushes on oral hygiene assessed over a 6-month observation period: A randomized clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","119"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neurology Neurosurgery & Psychiatry"],["dc.bibliographiccitation.lastpage","125"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Varges, Daniel. A."],["dc.contributor.author","Manthey, Henrike"],["dc.contributor.author","Heinemann, Uta"],["dc.contributor.author","Ponto, Claudia"],["dc.contributor.author","Schmitz, Matthias"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Krasnianski, Anna"],["dc.contributor.author","Breithaupt, Maren"],["dc.contributor.author","Fincke, Fabian"],["dc.contributor.author","Kramer, Katharina"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Zerr, Inga"],["dc.date.accessioned","2018-11-07T10:28:06Z"],["dc.date.available","2018-11-07T10:28:06Z"],["dc.date.issued","2017"],["dc.description.abstract","Objectives The main objective of the present study is to study the therapeutic efficiency of doxycycline in a double-blinded randomised phase II study in a cohort of patients with sporadic Creutzfeldt-Jakob disease (sCJD). Methods From the National Reference Center of TSE Surveillance in Germany, patients with probable or definite sCJD were recruited for a double-blinded randomised study with oral doxycycline (EudraCT 2006-003934-14). In addition, we analysed the data from patients with CJD who received compassionate treatment with doxycycline in a separate group. Potential factors which influence survival such as age at onset, gender, codon 129 polymorphism and cognitive functions were evaluated. The primary outcome measure was survival. Results Group 1: in the double-blinded randomised phase II study, 7 patients in the treatment group were compared with 5 controls. Group 2: 55 patients with sCJD treated with oral doxycycline were analysed and compared with 33 controls by a stratified propensity score applied to a Cox proportional hazard analysis. The results of both studies were combined by means of a random-effects meta-analysis. A slight increase in survival time in the doxycycline treatment group was observed (p=0.049, HR=0.63 (95% CI 0.402 to 0.999)). Conclusions On the basis of our studies, a larger trial of doxycycline should be performed in persons in the earliest stages of CJD."],["dc.identifier.doi","10.1136/jnnp-2016-313541"],["dc.identifier.isi","000393903700007"],["dc.identifier.pmid","27807198"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43348"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Bmj Publishing Group"],["dc.relation.issn","1468-330X"],["dc.relation.issn","0022-3050"],["dc.title","Doxycycline in early CJD: a double-blinded randomised phase II and observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Stützer, Alexandra"],["dc.contributor.author","Welp, Luisa M."],["dc.contributor.author","Raabe, Monika"],["dc.contributor.author","Sachsenberg, Timo"],["dc.contributor.author","Kappert, Christin"],["dc.contributor.author","Wulf, Alexander"],["dc.contributor.author","Lau, Andy M."],["dc.contributor.author","David, Stefan-Sebastian"],["dc.contributor.author","Chernev, Aleksandar"],["dc.contributor.author","Kramer, Katharina"],["dc.contributor.author","Politis, Argyris"],["dc.contributor.author","Kohlbacher, Oliver"],["dc.contributor.author","Fischle, Wolfgang"],["dc.contributor.author","Urlaub, Henning"],["dc.date.accessioned","2021-04-14T08:31:49Z"],["dc.date.available","2021-04-14T08:31:49Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41467-020-19047-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83722"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2041-1723"],["dc.title","Analysis of protein-DNA interactions in chromatin by UV induced cross-linking and mass spectrometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1000611"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","PLoS Biology"],["dc.bibliographiccitation.lastpage","19"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Heym, R. G."],["dc.contributor.author","Mayer, A."],["dc.contributor.author","Kramer, K."],["dc.contributor.author","Schmid, M."],["dc.contributor.author","Cramer, P."],["dc.contributor.author","Urlaub, H."],["dc.contributor.author","Jansen, R.-P."],["dc.contributor.author","Niessing, D."],["dc.date.accessioned","2017-09-07T11:44:17Z"],["dc.date.available","2017-09-07T11:44:17Z"],["dc.date.issued","2011"],["dc.description.abstract","In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For localization, transcripts are recognized by RNA-binding proteins and incorporated into motor-containing messenger ribonucleoprotein particles (mRNPs). To date, the molecular assembly of such mRNPs is not well understood and most details on cargo specificity remain unresolved. We used ASH1-mRNA transport in yeast to provide a first assessment of where and how localizing mRNAs are specifically recognized and incorporated into mRNPs. By using in vitro-interaction and reconstitution assays, we found that none of the implicated mRNA-binding proteins showed highly specific cargo binding. Instead, we identified the cytoplasmic myosin adapter She3p as additional RNA-binding protein. We further found that only the complex of the RNA-binding proteins She2p and She3p achieves synergistic cargo binding, with an at least 60-fold higher affinity for localizing mRNAs when compared to control RNA. Mutational studies identified a C-terminal RNA-binding fragment of She3p to be important for synergistic RNA binding with She2p. The observed cargo specificity of the ternary complex is considerably higher than previously reported for localizing mRNAs. It suggests that RNA binding for mRNP localization generally exhibits higher selectivity than inferred from previous in vitro data. This conclusion is fully consistent with a large body of in vivo evidence from different organisms. Since the ternary yeast complex only assembles in the cytoplasm, specific mRNA recognition might be limited to the very last steps of mRNP assembly. Remarkably, the mRNA itself triggers the assembly of mature, motor-containing complexes. Our reconstitution of a major portion of the mRNA-transport complex offers new and unexpected insights into the molecular assembly of specific, localization-competent mRNPs and provides an important step forward in our mechanistic understanding of mRNA localization in general."],["dc.identifier.doi","10.1371/journal.pbio.1000611"],["dc.identifier.gro","3142744"],["dc.identifier.isi","000289938900006"],["dc.identifier.pmid","21526221"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/182"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1545-7885"],["dc.relation.orgunit","Abteilung Forstgenetik und Forstpflanzenzüchtung"],["dc.title","A Cytoplasmic Complex Mediates Specific mRNA Recognition and Localization in Yeast"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3478"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Proteomics"],["dc.bibliographiccitation.lastpage","3494"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Schmidt, Carla"],["dc.contributor.author","Kramer, Katharina"],["dc.contributor.author","Urlaub, Henning"],["dc.date.accessioned","2018-11-07T09:09:10Z"],["dc.date.available","2018-11-07T09:09:10Z"],["dc.date.issued","2012"],["dc.description.abstract","Protein-RNA complexes play many important roles in diverse cellular functions. They are involved in a wide variety of different processes in growth and differentiation at the various stages of the cell cycle. As their function and catalytic activity are directly coupled to the structural arrangement of their components-proteins and ribonucleic acids-the investigation of protein-RNA interactions is of great functional and structural importance. Here we discuss the most prominent examples of protein-RNA complexes and describe some frequently used purification strategies. We present various techniques and applications of mass spectrometry to study protein-RNA complexes. We discuss the analysis of intact complexes as well as proteomics-based and crosslinking-based approaches in which proteins are cleaved into smaller peptides. This article is part of a Special Section entitled: Understanding genome regulation and genetic diversity by mass spectrometry. (c) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.jprot.2012.04.030"],["dc.identifier.isi","000307086500009"],["dc.identifier.pmid","22575267"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26194"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1874-3919"],["dc.title","Investigation of protein-RNA interactions by mass spectrometry-Techniques and applications"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","136"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Oral Rehabilitation"],["dc.bibliographiccitation.lastpage","144"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Rinke, Sven"],["dc.contributor.author","Kramer, Katharina"],["dc.contributor.author","Buergers, Ralf"],["dc.contributor.author","Roediger, Matthias"],["dc.date.accessioned","2018-11-07T10:18:59Z"],["dc.date.available","2018-11-07T10:18:59Z"],["dc.date.issued","2016"],["dc.description.abstract","This practice-based study evaluates the survival and success of conventionally luted metal-ceramic and zirconia molar crowns fabricated by using a prolonged cooling period for the veneering porcelain. Fifty-three patients were treated from 07/2008 to 07/2009 with either metal-ceramic crowns (MCC) or zirconia crowns (ZC). Forty-five patients (26 female) with 91 restorations (obser-vational period: 640 +/- 48 months) participated in a clinical follow-up examination and were included in the study. Estimated cumulative survival (ECSv), success (ECSc) and veneering ceramic success (ECVCSc) were calculated (Kaplan-Meier) and analysed by the crown fabrication technique and the position of the restoration (Cox regression model) (P < 005). Five complete failures (MCC: 2, ZC: 3) were recorded (5-year ECSv: MCC: 976%, (95% confidence interval (95%-CI): [93%; 100%]/ZC: 940%, (95%-CI): [87%; 100%]). Of the MCCs (n = 41), 850%, [95%-CI: (77%; 96%)] remained event-free, whereas the ECSc for the ZCs (n = 50) was 743% (95%-CI): [61%; 87%]. No significant differences in ECSv (P = 051), ECSc (P = 043) and ECVCSc (P = 036) were detected between the two fabrication techniques. Restorations placed on terminal abutments (n = 44) demonstrated a significantly lower ECVCSc (P = 0035), (5-year VCF-rate: 148%) than crowns placed on tooth-neighboured abutments (n = 47), (5-year VCF-rate: 43%). In the present study, zirconia molar crowns demonstrated a 5-year ECSv, ECSc and ECVCSc comparable to MCCs. Irrespective of the fabrication technique, crowns on terminal abutments bear a significantly increased risk for VCFs. Clinical investigations with an increased number of restorations are needed."],["dc.description.sponsorship","DeguDent GmbH; Dentsply DeTrey"],["dc.identifier.doi","10.1111/joor.12348"],["dc.identifier.isi","000368019700008"],["dc.identifier.pmid","26393865"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41563"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2842"],["dc.relation.issn","0305-182X"],["dc.title","A practice-based clinical evaluation of the survival and success of metal-ceramic and zirconia molar crowns: 5-year results"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2222"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","The EMBO Journal"],["dc.bibliographiccitation.lastpage","2234"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Schmitzova, Jana"],["dc.contributor.author","Rasche, Nicolas"],["dc.contributor.author","Dybkov, Olexander"],["dc.contributor.author","Kramer, Katharina"],["dc.contributor.author","Fabrizio, Patrizia"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Luehrmann, Reinhard"],["dc.contributor.author","Pena, Vladimir"],["dc.date.accessioned","2018-11-07T09:10:31Z"],["dc.date.available","2018-11-07T09:10:31Z"],["dc.date.issued","2012"],["dc.description.abstract","The yeast splicing factor Cwc2 contacts several catalytically important RNA elements in the active spliceosome, suggesting that Cwc2 is involved in determining their spatial arrangement at the spliceosome's catalytic centre. We have determined the crystal structure of the Cwc2 functional core, revealing how a previously uncharacterized Torus domain, an RNA recognition motif (RRM) and a zinc finger (ZnF) are tightly integrated in a compact folding unit. The ZnF plays a pivotal role in the architecture of the whole assembly. UV-induced crosslinking of Cwc2-U6 snRNA allowed the identification by mass spectrometry of six RNA-contacting sites: four in or close to the RRM domain, one in the ZnF and one on a protruding element connecting the Torus and RRM domains. The three distinct regions contacting RNA are connected by a contiguous and conserved positively charged surface, suggesting an expanded interface for RNA accommodation. Cwc2 mutations confirmed that the connector element plays a crucial role in splicing. We conclude that Cwc2 acts as a multipartite RNA-binding platform to bring RNA elements of the spliceosome's catalytic centre into an active conformation. The EMBO Journal (2012) 31, 2222-2234. doi:10.1038/emboj.2012.58; Published online 9 March 2012"],["dc.description.sponsorship","Max Planck Society"],["dc.identifier.doi","10.1038/emboj.2012.58"],["dc.identifier.isi","000303596900015"],["dc.identifier.pmid","22407296"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26508"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0261-4189"],["dc.title","Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]