Brodmann, Katja

[["dc.bibliographiccitation.firstpage","37"],["dc.bibliographiccitation.journal","Neuropsychologia"],["dc.bibliographiccitation.lastpage","47"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Freund, Nadja"],["dc.contributor.author","Valencia-Alfonso, Carlos E."],["dc.contributor.author","Kirsch, Janina"],["dc.contributor.author","Brodmann, Katja"],["dc.contributor.author","Manns, Martina"],["dc.contributor.author","Guentuerkuen, Onur"],["dc.date.accessioned","2018-11-07T10:17:37Z"],["dc.date.available","2018-11-07T10:17:37Z"],["dc.date.issued","2016"],["dc.description.abstract","Cerebral asymmetries are a ubiquitous phenomenon evident in many species, incl. humans, and they display some similarities in their organization across vertebrates. In many species the left hemisphere is associated with the ability to categorize objects based on abstract or experience-based behaviors. Using the asymmetrically organized visual system of pigeons as an animal model, we show that descending forebrain pathways asymmetrically modulate visually evoked responses of single thalamic units. Activity patterns of neurons within the nucleus rotundus, the largest thalamic visual relay structure in birds, were differently modulated by left and right hemispheric descending systems. Thus, visual information ascending towards the left hemisphere was modulated by forebrain top-down systems at thalamic level, while right thalamic units were strikingly less modulated. This asymmetry of top-down control could promote experience-based processes within the left hemisphere, while biasing the right side towards stimulus-bound response patterns. In a subsequent behavioral task we tested the possible functional impact of this asymmetry. Under monocular conditions, pigeons learned to discriminate color pairs, so that each hemisphere was trained on one specific discrimination. Afterwards the animals were presented with stimuli that put the hemispheres in conflict. Response patterns on the conflicting stimuli revealed a clear dominance of the left hemisphere. Transient inactivation of left hemispheric top-down control reduced this dominance while inactivation of right hemispheric top-down control had no effect on response patterns. Functional asymmetries of descending systems that modify visual ascending pathways seem to play an important role in the superiority of the left hemisphere in experience-based visual tasks. (C) 2015 Published by Elsevier Ltd."],["dc.description.sponsorship","DFG [SFB874, Gu 227/16-1]"],["dc.identifier.doi","10.1016/j.neuropsychologia.2015.08.014"],["dc.identifier.isi","000371944800005"],["dc.identifier.pmid","26282274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41266"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","1873-3514"],["dc.relation.issn","0028-3932"],["dc.title","Asymmetric top-down modulation of ascending visual pathways in pigeons"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","808"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","818"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Brodmann, Katja"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2015"],["dc.description.abstract","Misdiagnosing bipolar depression can lead to very deleterious consequences of mistreatment. Although depressive symptoms may be similarly expressed in unipolar and bipolar disorder, changes in specific brain networks could be very distinct, being therefore informative markers for the differential diagnosis. We aimed to characterize specific alterations in candidate large-scale networks (frontoparietal, cingulo-opercular, and default mode) in symptomatic unipolar and bipolar patients using resting state fMRI, a cognitively low demanding paradigm ideal to investigate patients.MethodsNetworks were selected after independent component analysis, compared across 40 patients acutely depressed (20 unipolar, 20 bipolar), and 20 controls well-matched for age, gender, and education levels, and alterations were correlated to clinical parameters.ResultsDespite comparable symptoms, patient groups were robustly differentiated by large-scale network alterations. Differences were driven in bipolar patients by increased functional connectivity in the frontoparietal network, a central executive and externally-oriented network. Conversely, unipolar patients presented increased functional connectivity in the default mode network, an introspective and self-referential network, as much as reduced connectivity of the cingulo-opercular network to default mode regions, a network involved in detecting the need to switch between internally and externally oriented demands. These findings were mostly unaffected by current medication, comorbidity, and structural changes. Moreover, network alterations in unipolar patients were significantly correlated to the number of depressive episodes. Conclusion: Unipolar and bipolar groups displaying similar symptomatology could be clearly distinguished by characteristic changes in large-scale networks, encouraging further investigation of network fingerprints for clinical use."],["dc.identifier.doi","10.1002/hbm.23070"],["dc.identifier.gro","3150744"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7534"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1065-9471"],["dc.title","Differentiating unipolar and bipolar depression by alterations in large-scale brain networks"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1099"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Structure & Function"],["dc.bibliographiccitation.lastpage","1114"],["dc.bibliographiccitation.volume","226"],["dc.contributor.author","Diekhof, Esther K."],["dc.contributor.author","Richter, Anja"],["dc.contributor.author","Brodmann, Katja"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2021-04-14T08:29:13Z"],["dc.date.available","2021-04-14T08:29:13Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s00429-021-02227-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82834"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1863-2661"],["dc.relation.issn","1863-2653"],["dc.title","Dopamine multilocus genetic profiles predict sex differences in reactivity of the human reward system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","172"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Creativity Research Journal"],["dc.bibliographiccitation.lastpage","178"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Brodmann, Katja"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2019-11-18T13:04:52Z"],["dc.date.accessioned","2021-10-27T13:21:29Z"],["dc.date.available","2019-11-18T13:04:52Z"],["dc.date.available","2021-10-27T13:21:29Z"],["dc.date.issued","2018"],["dc.description.abstract","creativity, reward, artist, fMRI"],["dc.description.abstract","Humans possess an invaluable ability of self-expression that extends into visual, literary, musical and many other fields of creation. More than any other profession, artists are in close contact with this subdomain of creativity. Probably one of the most intriguing aspects of creativity is its negative correlation with the availability of monetary reward. With this study we aimed to investigate the reactivity of the dopaminergic reward system in artists and non-artist controls using the desire-reason-dilemma (DRD) paradigm, which allows separate evaluation of reactivity to the acceptance and rejection of rewards. Using fMRI, we measured blood-oxygen-level-dependent (BOLD) responses in key regions of the reward system, namely the ventral striatum (VS), the ventral tegmental area (VTA), and the anterior ventral prefrontal cortex (AVPFC). In contrast to controls, artists presented significantly weaker VS activation in reward acceptance. Additionally, they showed stronger suppression of the VS by the AVPFC in reward rejection. No other differences in demographic or behavioral data were evidenced. These results support the existence of characteristic neural traits in artists, who display reduced reactions to monetary reward acceptance and increased reactions to monetary reward rejection."],["dc.identifier.doi","10.1080/10400419.2018.1414994"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16683"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92025"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.haserratum","/handle/2/74688"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Reactivity of the reward system in artists during acceptance and rejection of monetary rewards"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","submitted_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","454"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Brain Connectivity"],["dc.bibliographiccitation.lastpage","463"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Brodmann, Katja"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.date.accessioned","2018-02-12T08:31:11Z"],["dc.date.available","2018-02-12T08:31:11Z"],["dc.date.issued","2017"],["dc.description.abstract","A growing body of evidence indicates that the neuropeptide oxytocin (OT) alters the neural correlates of socioemotional and salience processing. Yet the effects of OT over important large-scale networks involved in these processes, such as the default mode (DM), ventral attention (VA), and cingulo-opercular (CO) networks, remain unknown. Therefore, we conducted a placebo-controlled crossover study with intranasal 24 IU OT in 38 healthy male subjects using a resting-state functional magnetic resonance imaging paradigm to investigate its impact over these three networks candidates. To understand the underlying mechanisms of the neuropeptide, we compared the intranetwork connectivity for each network candidate and also the internetwork connectivity across all networks between both treatment conditions. Based on the relevance of interindividual factors for OT effects, we correlated individual network changes with behavioral performance in a decision-making task and with impulsivity scores. Our results show that OT mainly alters connectivity in the VA, on one side reducing the coupling to regions that typically form the nodes of DM, an introspective and self-referential network, and on the other side increasing the coupling to the edges of the CO, which is involved in salience processing. The results of the internetwork analyses confirmed the specificity of the OT effects. Indeed, we observed significant correlations with the erroneous performance during decision-making but not with the obtained impulsivity scores. Overall, our data support that the modulation of functional connectivity within the VA is a basic mechanism by which OT directs attentional resources from internal to external cues, preparing the brain for context-dependent salience processing."],["dc.identifier.doi","10.1089/brain.2017.0528"],["dc.identifier.pmid","28762756"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/12104"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","2158-0014"],["dc.title","Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]